Cyclizine lactate

Calculate the percentage of w/v of cyclizine lactate in the injection from the... 

This type of extraction is employed in the BP assay of Cyclizine Lactate Injection the injection is diluted with dilute H2SO4 and then neutral and acidic excipients are extracted with ether. The solution is basified and the cyclizine is extracted into ether leaving the lactate ion, which would not have extracted during the initial ether extraction step, behind in the aqueous layer. For convenience in measurement by UV spectrophotometry and in order to carry out volumetric dilution of the extract, cyclizine is then back extracted into dilute H2SO4 and subjected to further dilution. 

Piperazine derivatives cetirizine hydrochloride cyclizine lactate hydroxyzine hydrochloride meclizine hydrochloride... 

Cyclacur, 831 Cycladiene, 537 Cyclaine, 659 Cyclamic acid, xvii Cyclandelate, 496 Cyclazocine, 496 Cyclimorph, 790 Cyclizine, 497, 561 Cyclizine hydrochloride, 497 Cyclizine lactate, 497 Cyclizinium chloride, 497 Cyclobarbital, 498 Cyclobarbitone, 498 Cyclobarbitone calcium, 498 Cyclobec, 535 Cyclobenzaprine, 499 Cyclobenzaprine hydrochloride, 499 Cyclobral, 496... 

Cyclizine has antimuscarinic properties and is a potent anti-emetic, effective for the control of postoperative and drug-induced nausea and vomiting. It has been used to prevent motion sickness, although diphenhydramine and promethazine are more effective. It is available in oral and parenteral formulations. In contrast to many other first-generation antihistamines sedation is not marked. It is available in tablet form as the hydrochloride and in injectable form as the lactate. Because of its anticholinergic action, blurred vision and dry mouth are associated with clinical doses. When given by rapid intravenous injection tachycardia may be a problem. Meclozine is a related drug which, like cyclizine, is used primarily for motion sickness. 

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