Hydroxypropyl methylcellulose drug release

Reynolds, T. D., Mitchell, S. A., and Balwinski, K. M. (2002), Investigation of the effect of tablet surface area/volume on drug release from hydroxypropyl methylcellulose controlled-release matrix tablets, Drug Dev. Ind. Pharm.., 28,457-466. 

Iyer et al. [50] investigated the effects of roto-granulation on the performance of hydroxypropyl methylcellulose (HPMC), gelatin, and poly(-vinylpyrrolidone) (Povidone, PVP). In this process, all three binders produced similar results. However, HPMC was preferred due to prolonged drug release profiles, smaller particle size, and better content uniformity. 

Rao, V., Haslam, J., and Stella, V. Controlled and complete release of a model poorly water-soluble drug, prednisolone, from hydroxypropyl methylcellulose matrix tablets using (SBE)(7m)-beta-cyclodextrin as a solubilizing agent. J. Pharm. Sci. 90 807—816, 2001. 

J. Siepmann, K. Podual, M. Sriwongjanya, et al. Anew model describing the swelling and drug release kinetics from hydroxypropyl methylcellulose tablets. J. Pharm. Sci. 88 65-72, 1999. 

Gao et al. [71, 72] developed a mathematical model to describe the effect of formulation composition on the drug release rate for hydroxypropyl methylcellulose-based tablets. An effective drug diffusion coefficient T>, was found to control the rate of release as derived from a steady-state approximation of Fick s law in one dimension ... 

Siepmann, J. and Peppas, N., Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC), Advanced Drug Delivery Reviews, Vol. 48, No. 2-3, 2001, pp. 139-157. 

Siepmann, J., Kranz, H., Peppas, N., and Bodmeier, R., Calculation of the required size and shape of hydroxypropyl methylcellulose matrices to achieve desired drug release profiles, International Journal of Pharmaceutics, Vol. 201, No. 2, 2000, pp. 151-164. 

Levina, M., and Rajabi-Siahboomi, A. R. (2004), The influence of excipients on drug release from hydroxypropyl methylcellulose matrices,/. Pharm. Sci., 93, 2746-2754. 

Lee BJ, Ryn SG, Cui JH. Controlled release of dual drug loaded hydroxypropyl methylcellulose matrix tablet using drug containing polymeric coatings. Int ] Pharm 1999 188 71-80. 

Keywords Hydrophilic matrix Monohthic Drug delivery Extended release Formulation Cellulose ethers Hypromellose (hydroxypropyl methylcellulose,... 

Hydrophilic matrices are the most commonly used oral extended-release systems because of their abihty to provide desired release profiles for a wide range of drugs, robust formulation, cost-effective manufacture, and broad regulatory acceptance of the polymers. Table 11.2 shows a fist of hydrophific polymers commonly used for fabrication of matrices [17, 18]. Hydrophobic materials are also used either alone (hydrophobic matrix systems) or in conjugation with hydrophilic matrix systems (hydrophilic-hydrophobic matrix systems) and are also fisted in Table 11.2. Cellulose ethers, in particular hypromeUose (hydroxypropyl methylcellulose, HPMC), have been the polymers of choice for the formulation of hydrophilic matrix systems. 

Khanvilkar, K.H. Ye, H. Moore, A.D. Influence of hydroxypropyl methylcellulose mixture, apparent viscosity, and tablet hardness on drug release using a 23 full factorial design. Drug Dev. Ind. Pharm. 2002, 28 (5), 601-608. 

S. Devjak Novak, et al.. Characterization of physicochemical properties of hydroxypropyl methylcellulose (HPMC) type 2208 and their influence on prolonged drug release from matrix tablets, /. Pharmaceut. Biomed., 66,136-143,2012. 

Finally, the cellulose derivatives are mosdy used as matrix formers for sustained release pellets due to their hydration and gel formation ability, with formation of a diffusion layer around the drug particles and delays its release into the dissolution medium. Certain cellulose esters, such as hydroxypropyl methylcellulose acetate succinate (Aqoat-AS ) or cellulose acetate phthalate, are used for the production of enteric release pellets, because they are soluble in the mildly basic intestinal fluid. 

The key consideration in the analysis of any sustained release dosage form as previously discussed (see Sections II.A, II.B, II.C.l, and II.C.2rg) is to determine what solvent or solvent system will be most appropriate to assure the dissolution of the drug and its excipients to make it amenable to HPLC analysis. Aqueous solubility of weak acids and bases is governed by the pfCa of the compound and the pFI of the medium. In an acidic or low pFI medium, weak acids will be unionized and will be more soluble in organic solvents. The reverse is the case for basic compounds as previously discussed in Section II.B. Because the formulation of sustained release dosage forms tend to rely on the use of insoluble plastics (i.e., methyl acrylate-methyl methacrylate, polyvinyl chloride, and polyethylene), hydrophilic polymers (i.e., methylcellulose, hydroxypropyl-methylcellulose, sodium carboxymethyl cellulose, and carbopol 934), and fatty compounds (i.e., waxes such carnauba wax and glyceryl tristearate), similar hydro-organic solvents and sample preparation steps that have been discussed for tablets and capsules can also used for their analysis by HPLC (see Sections II.A, II.B, II.C.l, and II.C.2). 

P. Borodkin, EE. Tucker, Drug release from hydroxypropyl-methylcellulose-polyvinyl acetate films, 7 Pharm Sci, 63 1359-1364,1974. 

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