Hydroxypropyl methylcellulose mixture

Khanvilkar, K.H. Ye, H. Moore, A.D. Influence of hydroxypropyl methylcellulose mixture, apparent viscosity, and tablet hardness on drug release using a 23 full factorial design. Drug Dev. Ind. Pharm. 2002, 28 (5), 601-608. 

Hydroxypropyl Methylcellulose (HPMC) Suzuki and Sunada. report the production of solid dispersions prepared with nicotinamide and HPMC as combined carriers using nifedipine and nitrendipine as model drugs. Their solid dispersions were obtained using the fusion method. After both the drug and HPMC were dissolved in the liquid melt of nicotinamide at 140°C, the fused mixture was cooled to solidify it. 

Dimethyl phthalate is used in pharmaceutical applications as a solvent and plasticizer for film-coatings such as hydroxypropyl methylcellulose, cellulose acetate and cellulose acetate-butyrate mixtures. ... 

Figure 4 Effect of increasing concentration of bile salts in physiological proportions on the activity of pancreatin lipase (FIP standard LS7). Reaction conditions are neutralized olive oil, 100 g/L hydroxypropyl methylcellulose, 11 g/L calcium, 10 mM NaCl, 100 mM and a mixture of bile salts (29.8% glycocholate, 24.5% glycochenodesoxy-cholate, 11.9% glycodeoxycholate, 12.6% taurocholate, 13.6% taurochenodesoxycholate, 7.6% taurodeoxycholate).

Propylene glycol (1000 g) and methylparaben (15 g) are mixed together until all solids are dissolved. Hydroxypropyl methylcellulose 4000 CPS (CPS refers to centipoise, a designation of viscosity 30 g) is added to and dispersed in the propylene glycol solution, and this resulting mixture is then added to an aqueous solution of disodium edetate (5.0 g) and sodium lauryl... 

A mixed ether, hydroxypropyl-methylcellulose, is also available. This is prepared by treating alkali cellulose with a mixture of methyl chloride and propylene oxide. Commercial grades of the polymer generally have a methoxy content of about 30% and a hydroxypropoxy content of about 5—10%. The mixed ether has increased organo-solubility and thermoplasticity over the methylcellulose counterparts. 

The GBR resin works well for nonionic and certain ionic polymers such as various native and derivatized starches, including sodium carboxymethylcel-lulose, methylcellulose, dextrans, carrageenans, hydroxypropyl methylcellu-lose, cellulose sulfate, and pullulans. GBR columns can be used in virtually any solvent or mixture of solvents from hexane to 1 M NaOH as long as they are miscible. Using sulfonated PDVB gels, mixtures of methanol and 0.1 M Na acetate will run many polar ionic-type polymers such as poly-2-acrylamido-2-methyl-l-propanesulfonic acid, polystyrene sulfonic acids, and poly aniline/ polystyrene sulfonic acid. Sulfonated columns can also be used with water glacial acetic acid mixtures, typically 90/10 (v/v). Polyacrylic acids run well on sulfonated gels in 0.2 M NaAc, pH 7.75. 

Methylcellulose is made by reaction of alkali cellulose with methyl chloride until the DS reaches 1.1—2.2. Hydroxypropylmethylcellulose [9004-65-3], the most common of this family of products, is made by using propylene oxide in addition to methyl chloride in the reaction MS values of the hydroxypropyl group in commercial products are 0.02—0.3. Use of 1,2-butylene oxide in the alkylation reaction mixture gives hydroxybutylmethylcellulose [9041-56-9, 37228-15-2] (MS 0.04—0.11). Hydroxyethylmethylcellulose [903242-2] is made with ethylene oxide in the reaction mixture. 

As with the alkylated polysaccharides, the physicochemical properties of hydroxyalkylated polysaccharides have continued to be investigated, particularly those of commercial value. The general characteristics of 0-(2-hydroxyethyl)cellulose have been described, together with pro-cedmes for the viscosimetric measurement of solutions of the polymer, and the macromolecular properties of the polymer in solution, described earlier, have been reviewed. The effect of increasing the substitution of both water-soluble 0-(2-hydroxyethyl)- and 0-(2-hydroxypropyl)-cellulose is to decrease their afiBnities for water. Water-soluble 0-(2-hy-droxypropyl) cellulose can be fractionated in a way analogous to that for O-methylcellulose by utilizing solvent—nonsolvent mixtures. For polysac-... 

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