Hydroxypropyl methylcellulose -based

Gao et al. [71, 72] developed a mathematical model to describe the effect of formulation composition on the drug release rate for hydroxypropyl methylcellulose-based tablets. An effective drug diffusion coefficient T>, was found to control the rate of release as derived from a steady-state approximation of Fick s law in one dimension ... 

Saravanan M, Nataraj KS, Ganesh KS. Hydroxypropyl methylcellulose based cephalexin extended release tablets Influence of tablet formulation, hardness and storage on in vitro release kinetics. Chem Pharm Bull 2003 5l(8) 978-83. 

Shah N, Railkar AS, Phuapradit W, Zeng FW, Malick AW. Effect of processing techniques in controlling the relca.se rate and mechanical strength of hydroxypropyl methylcellulose based hydrogel matrices. Eur J Pharm Biopharm 1996 42(3) 183-7. 

Perez-Gago, M.B., Serra, M., Alonso, M., Mateos, M., del Rfo, M.A. Effect of whey protein- and hydroxypropyl methylcellulose-based edible composite coatings on color change of fresh-cut apples. Postharvest Biol. Technol. 36, 77-85 (2005)... 

Siepmann, J. and Peppas, N., Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC), Advanced Drug Delivery Reviews, Vol. 48, No. 2-3, 2001, pp. 139-157. 

Generally, the barrier or rate-controlling films are more permeable to water than the carrier films. The materials used for this purpose consisted of a base, film forming water-soluble polymer in combination with at least one hydrophilic component such as hydroxypropyl methylcellulose or polyvinylpyrrolidone. The polymers used were the same as those for the carrier films. Some recent developments are discussed herein. 

Lehtola, V.-M. Heinamaki, J.T. Nikupaavo, P. Yliruusi, J.K. The mechanical and adhesion properties of aqueous-based hydroxypropyl methylcellulose coating systems containing polydextrose and titanium dioxide. Drug Dev. Ind. Pharm. 1995, 21 (6), 675-685. 

Rosoff M, Sheen P-C. Pan abrasion and polymorphism of titanium dioxide in coating suspensions. ] Pharm Sci 1983 72 1485. Lehtola VM, Heinamaki JT, Nikupaavo P, Yliruusi JK. Effect of titanium dioxide on mechanical, permeability and adhesion properties of aqueous-based hydroxypropyl methylcellulose films. Boll Chim Farm 1994 133(Dec) 709-714. 

Imran, M., El-Fahmy, S., Revol-Junelles, A.M., Desobry, S. 2010a. Cellulose derivative based active coatings Effects of nisin and plasticizer on physico-chemical and antimicrobial properties of hydroxypropyl methylcellulose films. Carbohydrate Polymers, 81 219-225. 

ECL = endothelial cell line, HY = hyaluronate-based viscoelastic substance, HPMC = hydroxypropyl-methylcellulose, V = Viscoat (4% chondroitin sulfate and 3% hyaluronate), > = more than, ns = not statistically significant... 

Lehtola, V., Hein, J., Nikupaavo, P., Yliruusi, J. Effect of Some Excipjents and Compression Pressure on the Adhesion of Aqueous-Based Hydroxypropyl Methylcellulose Film Coatings to Tablet Surface. Drug Dev. Ind. Pharm. 1995 21(12) 1365-1375. 

Model saturation with a viscous fluid is an essential part of a model preparation in centrifuge-based liquefaction research, requiring strict control for superior results. A solution of Hydroxypropyl Methylcellulose in water was used as the pore fluid with a viscosity of 50 times that of water, in order to achieve the so-called viscosity scaling at 50-g and overcome the conflict between time scaling in flow... 

Jimenez A, Fabra MJ, Talens P, Chiralt A (2010) Effect of lipid self-association on the microstructure and physical properties of hydroxypropyl-methylcellulose edible films containing fatty acids. Carbohydr Polym 82 585-593 Jimenez A, Fabra MJ, Talens P, Chiralt A (2013) Phase transitions in starch based films containing fatty acids. Effect on water sorption and mechanical behavior. Food Hydrocolloid 30 408-418 Jin Z, Hsieh F, Huff HE (1994) Extmsion of com meal with soy fiber, salt, and sugar. Cereal Chem 7 227-234... 

The key consideration in the analysis of any sustained release dosage form as previously discussed (see Sections II.A, II.B, II.C.l, and II.C.2rg) is to determine what solvent or solvent system will be most appropriate to assure the dissolution of the drug and its excipients to make it amenable to HPLC analysis. Aqueous solubility of weak acids and bases is governed by the pfCa of the compound and the pFI of the medium. In an acidic or low pFI medium, weak acids will be unionized and will be more soluble in organic solvents. The reverse is the case for basic compounds as previously discussed in Section II.B. Because the formulation of sustained release dosage forms tend to rely on the use of insoluble plastics (i.e., methyl acrylate-methyl methacrylate, polyvinyl chloride, and polyethylene), hydrophilic polymers (i.e., methylcellulose, hydroxypropyl-methylcellulose, sodium carboxymethyl cellulose, and carbopol 934), and fatty compounds (i.e., waxes such carnauba wax and glyceryl tristearate), similar hydro-organic solvents and sample preparation steps that have been discussed for tablets and capsules can also used for their analysis by HPLC (see Sections II.A, II.B, II.C.l, and II.C.2). 

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