Hydroxypropyl cellulose films

Nishio, Y. Yamane, Y. Takahashi, T. Morphological studies of liquid-crystalline cellulose derivatives. II. Hydroxypropyl cellulose films prepared from liquid-crystalline aqueous solutions. J. Polym. Sci. Polym. Phys. Ed. 1985, 23 (5), 1053-1064. 

A Castellan, A Nourmamode, C Noutary, C Belin, and P Fornier de Violet. Photoyellowing of Milled Wood Lignin and Peroxide-Bleached Milled Wood Lignin in Solid 2-Hydroxypropyl Cellulose Films after Sodium Borohydride Reduction and Catalytic Hydrogenation in Solution A Ruorescence Spectroscopic Study. J. Wood Chem. Technol. 12 19-33, 1992. 

Prodduturi, S., Manek, R.V., Rolling, W.M., Stodghill, S.P., Repka, M.A. Water vapor sorption of hot-melt extruded hydroxypropyl cellulose films Effect on physico-mechanical properties, release characteristics, and stability. J. Pharm. Sci. 2004, 93(12), 3047-3056. 

Ding Jiadong, Feng Jun, and Yang Yuliang. Sinusoidal supermolecular structure of band textures in a presheared hydroxypropyl cellulose film. Polym. J. 27 no. 11 (1995) 1132-1138. 

In another study, the liquid crystalline order in cellulose derivative solutions observed in rheological investigations is preserved in solid films by slow evaporation of the solvent and is evidenced in optical microscopy images [125]. Thus, Figures 14.8 a, b, and c of cellulose acetate phthalate (CAP) and hydroxypropyl cellulose films, show the... 

The materials used in these type of films include lipids, polysaccharides, and proteins. Starch (Maizura and others 2007), methylcellulose (Olivas and others 2003), hydroxypropyl cellulose (Brindle and Krochta 2008), chitosan (No and others 2007), xanthan gum (Mei and others 2002), alginate or zein (Zapata and others 2008), and soy protein (Park and others 2001) have been used for edible coatings. 

Protective Film Coating with Hydroxypropyl Cellulose + Kollidon VA 64... 

Hydroxy propyl methyl cellulose (HPMC).35 HPMC is a partly O-methylated and 0-(2-hydroxypropylated) cellulose available in several grades that vary in viscosity and extent of substitution. It is used widely in pharmaceutical formulations, especially in oral products, as a tablet binder, in film coating, and as controlled release matrix. Soluble in cold water, it forms a viscous colloidal solution. For a 2% aqueous solution (20°C), viscosity can range from 2.4 to 120,000 mPa-s. High-viscosity grades can be used to retard the release of water-soluble drugs from a matrix. 

Recently, 2-hydroxypropyl cellulose (HPC) was demonstrated to be a very suitable matrix for UV/Vis absorption study of photoyellowing of milled-wood lignin in the solid state [10] where clean kinetics of discolouration were established after different chemical treatments of the lignin in solution. This indicates the importance in the discolouration process of phenolic structures without carbonyl groups and conjugated double bonds. The present communication describes a similar photochemical study on quinones and hydroquinones incorporated in HPC films under comparative concentrations ( 6.5xl0"5 mol/g HPC). For comparison, we also use UV/Vis reflectance spectroscopy to examine the behaviour of these compounds adsorbed on filter paper after light-exposure. 

There have been continuing works by Suto et al. [213-217] on the preparation of cholesteric solid films of hydroxypropyl cellulose (HPC) crosslinked preferably with glutaraldehyde. Coloring conditions [213,217], swelling [215, 216], and tensile-creep behavior [214] of the crosslinked HPC films were examined. Also, the permselectivity of O2/N2 gasses for such liquid-crystalline cellulosic films was reported to become greater than that for the corresponding amorphous ones [218]. 

Tanaka [4] prepared 30 mm-thick retardation films consisting of mixed esters of hydroxypropyl cellulose and acryloyl and n-butyryl chlorides, (XI), having a retardation value of 180nm at a wavelength of 550 nm after photo polymerization. 

Fig. 14 The effect of lubricant concentration (% w/w) on the measured adhesion (kPa) of hydroxypropyl methyl-cellulose films (A) Pharmacoat 606 (B) Methocel 60HG viscosity 50 ( ) stearic acid ( ) magnesium stearate ( ) calcium stearate. (From Ref. l)...

J.K. Effect of some excipients and compression pressure 140. on the adhesion of aqueous-based hydroxypropyl methyl-cellulose film coatings to tablet surface. Drug Dev. Ind. 

In oral products, hydroxypropyl cellulose is primarily used in tableting as a binder, film-coating, and extended-release-matrix former.Concentrations of hydroxypropyl cellulose of 2-6% w/w may be used as a binder in either wet-granulation or dry, direct-compression tableting processes. " Concentrations of 15-35% w/w of hydroxypropyl cellulose may be used to produce tablets with an extended drug release. The release rate of a drug increases with decreasing viscosity of... 

It is also used in hot-melt extruded films for topical use. When it is produced with chlorpheniramine maleate, the matrix is stabilized, allowing film processing at lower temperatures. Mucoadhesive hydroxypropyl cellulose microspheres have been prepared for powder inhalation preparations. A specification for hydroxypropyl cellulose is included in the Food Ghemicals Godex (EGG). 

Lindberg NO. Water vapour transmission through free films of hydroxypropyl cellulose. Acta Pharm Suec 1971 8 541-548. Banker G, Peck G, Williams E, et al. Evaluation of hydroxypro-pylcellulose and hydroxypropylmethylcellulose as aqueous based film coatings. Drug Dev Ind Pharm 1981 7 693-716. 

Discovery of the formation of liquid crystalline solutions by cellulosics in the mid-1970s has resulted in attempts to develop new cellulosics products with properties superior to those of conventional cellulosic. Following the first observation of mesophases formed in aqueous solutions of hydroxypropyl cellulose (HPC), a variety of other cellulose derivatives have been reported to form liquid crystals. Liquid crystalline solutions of cellulose and its derivatives provide a potential route to high-modulus and high-tenacity cellulosic fibers, films, and other high-performance products. 

Surface wettability trends and the blood component adhesion of some cellulose acetate phthalate/hydroxypropyl cellulose blend films have been analysed in order to allow their adaption to biomedical applications. It is important to ascertain the antimicrobial activity of the studied blends in order to develop new applications in the biomedical field. 

Acetoxypropyl cellulose (APC) [74, 75] 2-Hydroxypropyl cellulose (HPC) [76] Trifluoroacetate ester of HPC [77] Propanoate ester of HPC [78] Benzoate ester of HPC [79] thin films... 

Water vapor sorption (WVS) is used to assess the hygroscopicity of the hot melt extruded formulations. WVS is used in quantification of amorphous content in pharmaceutical solids. Prodduturi et al. investigated the use of rapid dynamic vapor sorption techniques for analysis of films containing hydroxypropyl cellulose and clotrimazole. ... 

Hydroxypropyl cellulose (HPC) possesses good film-forming properties, and high surface activity compared to most other hydrocolloids. The films are flexible, glossy, and nontacky. ... 

Imran, M., El-Fahmy, S., Revol-Junelles, A.M., Desobry, S. 2010a. Cellulose derivative based active coatings Effects of nisin and plasticizer on physico-chemical and antimicrobial properties of hydroxypropyl methylcellulose films. Carbohydrate Polymers, 81 219-225. 

---