Hydroxypropyl cellulose films, extruded

Prodduturi, S., Manek, R.V., Rolling, W.M., Stodghill, S.P., Repka, M.A. Water vapor sorption of hot-melt extruded hydroxypropyl cellulose films Effect on physico-mechanical properties, release characteristics, and stability. J. Pharm. Sci. 2004, 93(12), 3047-3056. 

It is also used in hot-melt extruded films for topical use. When it is produced with chlorpheniramine maleate, the matrix is stabilized, allowing film processing at lower temperatures. Mucoadhesive hydroxypropyl cellulose microspheres have been prepared for powder inhalation preparations. A specification for hydroxypropyl cellulose is included in the Food Ghemicals Godex (EGG). 

Water vapor sorption (WVS) is used to assess the hygroscopicity of the hot melt extruded formulations. WVS is used in quantification of amorphous content in pharmaceutical solids. Prodduturi et al. investigated the use of rapid dynamic vapor sorption techniques for analysis of films containing hydroxypropyl cellulose and clotrimazole. ... 

A possible way to lower the costs of fibers and films of regenerated cellulose would be to run cellulose through a twin-screw ultrasonic extruder with a minimum of solvent and pass the extrudate through a stream of hot air to recover the solvent for reuse. This stronger cellophane could be used in place of many plastic films used today. A great number of derivates of cellulose have been made. Methyl, ethyl, carboxymethyl, hydroxyethyl, and hydroxypropyl ethers are made commercially today. These are used as water-soluble polymers, except for ethylcellulose, which is a tough plastic used in screwdriver handles and such. 

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