Melt extruded film

ExxonMobil Chemical Company, On-line properties analysis of a molten polymer by Raman spectroscopy for control of a mixing device. Inventors D.G. Marrow, D.A. Yahn, and T.R. Veariel. 20 pp. (inch 10 fig.). Appl. 22 Jul 2005. Int. Cl. GOIJ 3/44 GOIN 21/65. US Patent Application Publication 2007/0019190 Al 105. V.S. Tumuluri, M.S. Kemper, I.R. Lewis, S. Prodduturi, S. Majumdar, B.A. Avery and M.A. Repka, Off-line and on-line measurements of drug-loaded hot-melt extruded films using Raman spectroscopy, Int. J. Pharm., 357, 77-84 (2008). 

V.S. Tumuluri, M.S. Kemper, I.R. Lewis, S. Prodduturi, S. Majumdar, B.A. Avery and M. Repka, Off-line and on-hne measnrements of dmg-loaded hot-melt extruded films using Raman spectroscopy, Int. J. Pharm., 357, 77-84 (2008). 

Fig. 13 Differential scanning calorimetry profiles of hot-melt extruded films containing chlorpheniramine maleate and hydroxypropylcellulose (A) chlorpheniramine maleate (CPM) (B) 10% CPM and 90% HPC (Klucel HF) physical mix and (C) 10% CPM and 90% HPC (Klucel HF) extruded film. (From Ref. )...

Fig. 15 Glass transition temperatures of films containing different levels of Vitamin E TPGS incorporated into two formulations of HPC/PEO hot-melt extruded films n = 4). (From Ref - l)...

A bioadhesive hot-melt extruded film for intraoral drug delivery and the processing thereof has been patented.f Applications of these films may be utilized in transmucosal drug delivery or even transder-mal systems. The films may be produced separately and layered after extrusion, or in some cases, a multilayered system may be extruded in one continuous process. Currently on the market is an extruded film device that is utilized as a denture adhesive. This system includes thermoplastic polymers that have a bioadhesive quality when the film is wetted. Before application and wetting, however, this thin film may be held in one s hand and shaped or cut. This device is again produced by a one-step, continuous process using hot-melt extrusion technology. 

Table 7 Processing conditions for hot-melt extruded films containing a 50 50 ratio of hydroxypropylcellulose to polyethylene oxide with vitamin E TPGS as an additive n — 4)...

Fig. 19 Example of a force-deflection profile obtained from a butt bioadhesion experiment utilizing hot-melt extruded films in vivo using a Chatillon digital force gauge attached to a motorized test stand. (From Ref. l)...

Fig. 20 Force of adhesion of hydroxypropylcellulose hot-melt extruded films containing various polymer additives (12 subjects, n — 6). (From Ref l)...

Repka, M.A. McGinity, J.W. Physical-mechanical, moisture absorption and bioadhesive properties of hydroxy-propylcellulose hot-melt extruded films. Biomaterials 2000, 21 (14), 1509-1517. 

It is also used in hot-melt extruded films for topical use. When it is produced with chlorpheniramine maleate, the matrix is stabilized, allowing film processing at lower temperatures. Mucoadhesive hydroxypropyl cellulose microspheres have been prepared for powder inhalation preparations. A specification for hydroxypropyl cellulose is included in the Food Ghemicals Godex (EGG). 

Repka, M.A., Gutta, K., Prodduturi, S., Munjal, M., Stodghill, S.P. Characterization of cellulosic hot-melt extruded films containing lidocaine. Eur. J. Pharm. Biopharm. 2005, 59(1), 189-196. 

Repka, M.A. Prodduturi, S. StodghiU, S.P. Production and characterization of hot-melt extruded films containing clotrimazole. Drug Dev. Ind. Pharm. 2003,29(1), 757—765. 

In addition to the recast samples, as-received, melt extruded films of the nylon 6 and nylon 6/layered silicate nanocomposite (7.5wt%) were exposed to the oxygen plasma. The nylon 6 nanocomposite develops of a colorful, interferometric surface reflection upon exposure (not shown). The optical interference effects suggest highly uniform alteration of the surface composition on the order of 200-500 nm. 

Alexy P, Bakos D., Hanzelova S., Cikonova G., Kramarova Z., Hoffman J., Julinova M., ChieUini E., Cinelli R Poly(vinyl alcohol)-collagen hydrolysate thermoplastic blends II. Water penetration and biodegradabUity of melt extruded films. Polymer Testing 22 (2003) 811. 

Birefringence measurements, using optical microscopy of the melt extruded films, shows... 

Progress in manufacturing techniques has been made. Although melt-extruded films were the norm, the industry is moving to a solution-cast film process to reduce costs and improve manufacturing throughput efficiency. In this process, the ionic form of the polymer is solubilized in alcoholic solution, such as propanol, and then fabricated into a film of desired thickness. The conversion of the non-ionic polymer to an ionic phase, ready for use in a fuel cell, is carried out prior to the solubilization step. 

McGinity J, Repka M. Hot melt extruded films. Drug Deliv Technol 2004 4(7) 40-47. Sood A, Ashokraj Y, Panchagnula R. Use of extrusion spenronization to develop controlled release dosage forms for diltiazem hydrochloride. Pharm Tech 2004 April 62-85. Jalal IM, Malinowski HJ, Smith WE. Tablet granulations composed of spherical-shaped particles. J Pharm Sci 1972 61 1466-1468. 

Polypropylene melt spinning (or fibrillation of melt-extruded film)... 

Table 10.12 Normalized weight loss of poly(lactic acid)/poly(vinyl acetate) (95/5) melt extruded films after different treatment (Gajria ef a/., 1996)...

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