Hydroxyanisole

ButylatedHydroxyAnisole (BHA). This material is an oxidation inhibitor and has been accepted for use in foods where the use of butylated hydroxytoluene (BHT) is restricted (see Food additives). It is manufactured by the alkylation of 4-hydroxyanisole [150-76-5] with isobutylene that yields a mixture of 2- and S-Z fZ-butyl isomers as products (124). 

BHA 2-tert-butyl-4-hydroxyanisole 3-tert-butyl-4-hydroxyanisole... 

Rustin GJ, Stratford MR, Lamont A, et al Phase I study of intravenous 4-hydroxyanisole. EurJ Cancer 2%-.U61-U6 , 1992... 

Figure 4. Intrinsic viscosity of polystyrene samples irradiated in benzene solution under various conditions. Polystyrene concentration 7.69x 10-2 M and initiator I concentration 3.12x 10-3 M. vacuum nitrogen saturated air saturated V oxygen saturated 3.12 3 / 3-tert-butyl-4-hydroxyanisole 3.12x 10-3 M 1.4-diazobicyclo(2.2.2)-octane (DABCO).

Moreover, DCQAs (1,5-, 3,4- and 4,5-DCQAs), with antioxidative activity, have been isolated from the leaves of garland (Chrysanthemum coronarium L.) [113], The garland Chrysanthemum coronarium L.) has been regarded as a health food in East Asia because the edible portions, such as leaf and stem, contain abundant -carotene, iron potassium, calcium, and dietary fiber. In addition to these common nutrients, some compounds responsible for the chemoprevention of cancers and other diseases are thought to be contained in garland. The antioxidative activity of DCQAs has been assayed by the decay curves of P-carotene. The antioxidative ability of 1 pg/ml these compounds are nearly equal to that of 0.1 pg/ml 3-/er/-butyl-4-hydroxyanisole (BHA). 

Superoxide dismutase Polyunsaturated fatty acid 1,1 -Diphenyl-2-picrylhydrazyl Low density lipoprotein Phorbol-12-mysri state-13-acetate 12-0-Tetradecanoylphorbol-13-acetate Di-O-caffeoylquinic acids Di-O-caffeoylquinic acid Herpes simplex virus type 1 Human immunodeficiency virus Acquired immunodeficiency syndrome Human immunodeficiency virus type-1 CafFeoylquinic acid derivatives 3-fer/-Butyl-4-hydroxyanisole... 

A paired-ion, reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of sweeteners (dulcin, saccharin-Na, and acesulfame-K), preservatives (sodium dehydroacetate, SA, salicyclic acid, BA, succinic acid, methyl-para-hydroxybenzoic acid, ethyl-para-hydroxybenzoic acid, n-propyl-para-hydroxybenzoic acid, n-butyl-para-hydroxybenzoic acid, and isobutyl-para-hydroxybenzoic acid), and antioxidants (3-tertiary-butyl-4-hydroxyanisole and tertiary-butyl-hydroquinone). A mobile phase of acetonitrile-50 ml aqueous tr-hydroxyisobutyric acid solution (pH 4.5) (2.2 3.4 or 2.4 3.6, v/v) containing 2.5 mM hexadecyltrimethylammonium bromide and a Clg column with a flow rate of 1.0 ml/min and detection at 233 nm were used. This method was found to be very reproducible detection limits ranged from 0.15 to 3.00 p,g. The retention factor (k) of each additive could be affected by the concentrations of hexadecyltrimethylammonium bromide and a-hydroxyisobu-tyric acid and the pH and ratio of mobile phase. The presence of additives in dried roast beef and sugared fruit was determined. The method is suitable for routine analysis of additives in food samples (81). 

Dock, L., Cha, Y-N., Jernstrom, B., and Moldeus, P. Effect of 2(3)-tert-butyl-4-hydroxyanisole on benzo(a)pyrene Metabolism and NDA-binding of Benzo(a)pyrene Metabolites in Isolated Mouse Hepatocytes. Chem. Biol. Interact., 41 ... 

Antimutagenic Effects of 2(3)-tert-butyl-4-hydroxyanisole and of antimicrobial agents. Cancer Res. 38 4478-4485, 1978. 

BHA occurs as a white or slightly yellow, waxy solid. It is predominantly 3-t< rt-butyl-4-hydroxyanisole (3-BHA), with varying amounts of 2-t< rt-butyl-4-hydroxyanisolc (2-BHA). It melts between 48° and 63°. It is freely soluble in alcohol and in propylene glycol, and insoluble in water. 

Standard Preparation Dissolve together accurately weighed quantities of USP Reference Standards 3-tert-Butyl-4-hydroxyanisole and 2-tert-Butyl-4-hydroxyanisole to final concentrations of 9 mg/mL and 1 mg/mL, respectively, in sufficient Internal Standard Solution to make 10 mL. 

A number of inhibitors of this enzyme are known. They include epoxides that are hydrolyzed by the enzymes, such as trichloropropene oxide, metal ions such as Hg2+, Zn2+, and Cd2+ and 2-bromo-4 -acetophenone, a potent inhibitor that binds to imidazole nitrogen atoms. Microsomal epoxide hydrolase can be induced by compounds such asphenobarbital, Arochlor 1254,2(3)-t-butyl-4-hydroxyanisole (BHA), and 3,5-di-f-butyl-hydroxytoluene (BHT). Many microsomal epoxide hydrolase inducers are inducers also of CYP and produce a general proliferation of the endoplasmic reticulum. Induction does, however, involve an increase in the mRNA specific for the hydrolase. 

Chemoprevention is a strategy used to block or suppress carcinogenesis and degenerative disease using dietary or pharmacological compounds. These chemo-preventive compounds include phenols [such as tm-butyl 4-hydroxyanisole (BHA), t-BHQ (active metabolite of BHA), ethoxyquine, curcumin (from turmeric) and resveratrol (from grapes)] and sulfur compounds [such as oltiplaz, sulforaphane... 

Tetramethyl-l,3-disilaisoindoline N,iV-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid Butyl glycidyl ether 3-fgrt-Butyl-4-hydroxyanisole... 

SYNS ANTRANCINE 12 BHA (FCC) D BUTYL-HYDROXYANISOLE tert-BUTYLHYDROXYANISOLE ten-BUTYI 4-HYDROXYANISOLE 2(3)-tert-BUTYL-4-HYDROXYANISOLE BUTYLOHYDROKSYANIZOL (POLISH) EMBANOX FEMA No. 2183 ... 

C11H1405 genipin 6902-77-8 25.00 1.1972 2 22448 C11H1602 tert-butyl-4-hydroxyanisole 25013-16-5 24.83 1.0121 2... 

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