Dietary butylated hydroxyanisole

The foregoing method has been adapted by Davalos and others (2004) using a conventional fluorescence microplate reader and applied to pure compounds (benzoic and cinnamic acids and aldehydes, flavonoids, and butylated hydroxyanisole) and to wines, as well as to commercial dietary antioxidant supplements. Eberhardt and others (2005) have also proposed a similar method for the determination of the antioxidant activity in broccoli. 

Tumorigenicity Although butylated hydroxytoluene can induce tumors in rats, others have suggested that it may protect tissues against the carcinogenic effects of many different substances. In a study of the association between dietary intake of the synthetic antioxidants butylated hydroxyanisole and butylated hydroxytoluene and the risk of stomach cancer in 120852 men and women aged 55-69 years there was no significant association [25 ]. 

The fact that the same enzyme system can be involved both in lethal synthesis and detoxication can again lead to interactions between different dietary anutrients or drugs. Thus a number of antioxidants (butylated hydroxytoluene, butylated hydroxyanisole, ethoxy-quin ) induce mixed-function monooxygenase, a process which may be considered an adaptive response. As a consequence of this induction, the toxicity of co-administered compounds may be enhanced or reduced, depending on whether the increased activity of the enzymes leads to increased production of toxic or inactive metabolites. In addition, the activity of these pathways is affected by nutritional status, which can further modify the toxic response. The problems of defining a unique no-untoward-effect level are obvious. 

Moreover, DCQAs (1,5-, 3,4- and 4,5-DCQAs), with antioxidative activity, have been isolated from the leaves of garland (Chrysanthemum coronarium L.) [113], The garland Chrysanthemum coronarium L.) has been regarded as a health food in East Asia because the edible portions, such as leaf and stem, contain abundant -carotene, iron potassium, calcium, and dietary fiber. In addition to these common nutrients, some compounds responsible for the chemoprevention of cancers and other diseases are thought to be contained in garland. The antioxidative activity of DCQAs has been assayed by the decay curves of P-carotene. The antioxidative ability of 1 pg/ml these compounds are nearly equal to that of 0.1 pg/ml 3-/er/-butyl-4-hydroxyanisole (BHA). 

Chemoprevention is a strategy used to block or suppress carcinogenesis and degenerative disease using dietary or pharmacological compounds. These chemo-preventive compounds include phenols [such as tm-butyl 4-hydroxyanisole (BHA), t-BHQ (active metabolite of BHA), ethoxyquine, curcumin (from turmeric) and resveratrol (from grapes)] and sulfur compounds [such as oltiplaz, sulforaphane... 

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