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Hydrazines ketones

One other possibility to make 1,2-diazepines by forming four bonds (bonds b, d, e, and g) should be explored. This would be a one-pot synthesis from fragments like hydrazine, ketone, and aldehyde as shown in 90, leading to 1,2-diazepines 91 (Scheme 19). [Pg.157]

FSI FVMQ Fluorosilicone Fluorinated organic silicone polymer Moderate or oxidizing chemicals, ozone, aromatic chlorinated solvents, bases Brake fluids, hydrazine, ketones... [Pg.43]

C HgNjOjS. Colourless needles, with iH20. Prepared by reducing diazotized sulphanilic acid with an excess of sodium sulphite. It is a typical hydrazine in its reactions with ketones, and with acetoacetic ester. The latter reaction gives rise to the tartrazine dyestuffs, and is much used commercially. [Pg.305]

Hydrazine and its alkylated derivatives are used as rocket fuels in organic chemistry, substituted phenylhydrazines are important in the characterisation of sugars and other compounds, for example aldehydes and ketones containing the carbonyl group C=0. [Pg.224]

Phenyl hydrazine condenses readily with aldehydes and ketones to give phenylhydrazonesy which, being usually crystalline compounds of sharp... [Pg.229]

Aromatic ketones usually have relatively high boiling points, but distil with little or no decomposition. Many are solids. The vapours generally burn with a smoky flame. They react with the 2 4-dinitrophenyll hydrazine reagent (Section 111,74,/) or with the phenylhydrazine reagent... [Pg.741]

Oximes, hydrazines and semicarbazones. The hydrolysis products of these compounds, t.e., aldehydes and ketones, may be sensitive to alkali (this is particularly so for aldehydes) it is best, therefore, to conduct the hydrolysis with strong mineral acid. After hydrolysis the aldehyde or ketone may be isolated by distillation with steam, extraction with ether or, if a solid, by filtration, and then identified. The acid solution may be examined for hydroxylamine or hydrazine or semicarbazide substituted hydrazines of the aromatic series are precipitated as oils or solids upon the addition of alkali. [Pg.1075]

Some examples of the use of a temporary additional site of coordination have been published. Burk and Feaster have transformed a series of ketones into hydrazones capable of chelating to a rhodium catalyst (Scheme 4.7). Upon coordination, enanti os elective hydrogenation of the hydrazone is feasible, yielding N-aroylhydrazines in up to 97% ee. Finally, the hydrazines were transformed into amines by treatment with Sml2. [Pg.112]

Inspired by the work of Burk and Feaster ) we attempted to use (2-pyridyl)hydrazine (4.36) as a coordinating auxiliary (Scheme 4.10). Hydrazines generally react effidently with ketones and aldehydes. Hence, if satisfactory activation of the dienophile can be achieved through coordination of a Lewis acid to the (2-pyridyl)hydrazone moiety in water. Lewis-add catalysis of a large class of ketone- and aldehyde-activated dienophiles is antidpated Subsequent conversion of the hydrazone group into an amine functionality has been reported previously by Burk and Feaster ... [Pg.113]

Pyridyl)hydrazine (Aldrich), 4-acetylpyridine (Acros), N,N,N -trimethylethylenediamine (Aldrich), methylrhenium trioxide (Aldrich), InQj (Aldrich), Cu(N0j)2-3H20 (Merck), Ni(N03)2-6Il20 (Merck), Yb(OTf)3(Fluka), Sc(OTf)3 (Fluka), 2-(aminomethyl)pyridine (Acros), benzylideneacetone (Aldrich), and chalcone (Aldrich) were of the highest purity available. Borane dimethyl sulfide (2M solution in THE) was obtained from Aldrich. Methyl vinyl ketone was distilled prior to use. Cyclopentadiene was prepared from its dimer immediately before use. (R)-l-acetyl-5-isopropoxy-3-pyrrolin-2-one (4.15) has been kindly provided by Prof H. Hiemstra (University of Amsterdam). [Pg.119]

The problem of the synthesis of highly substituted olefins from ketones according to this principle was solved by D.H.R. Barton. The ketones are first connected to azines by hydrazine and secondly treated with hydrogen sulfide to yield 1,3,4-thiadiazolidines. In this heterocycle the substituents of the prospective olefin are too far from each other to produce problems. Mild oxidation of the hydrazine nitrogens produces d -l,3,4-thiadiazolines. The decisive step of carbon-carbon bond formation is achieved in a thermal reaction a nitrogen molecule is cleaved off and the biradical formed recombines immediately since its two reactive centers are hold together by the sulfur atom. The thiirane (episulfide) can be finally desulfurized by phosphines or phosphites, and the desired olefin is formed. With very large substituents the 1,3,4-thiadiazolidines do not form with hydrazine. In such cases, however, direct thiadiazoline formation from thiones and diazo compounds is often possible, or a thermal reaction between alkylideneazinophosphoranes and thiones may be successful (D.H.R. Barton, 1972, 1974, 1975). [Pg.35]

Low-valent nitrogen and phosphorus compounds are used to remove hetero atoms from organic compounds. Important examples are the Wolff-Kishner type reduction of ketones to hydrocarbons (R.L. Augustine, 1968 D. Todd, 1948 R.O. Hutchins, 1973B) and Barton s olefin synthesis (p. 35) both using hydrazine derivatives. [Pg.97]

HydraZones and Azines. Depending on reaction conditions, hydrazines react with aldehydes and ketones to give hydrazones (33), azines (34), and diaziddines (35), the latter formerly known as isohydrazones. [Pg.281]

The methyl ethyl ketazine forms an immiscible upper organic layer easily removed by decantation. The lower, aqueous phase, containing acetamide and sodium phosphate, is concentrated to remove water formed in the reaction and is then recycled to the reactor after a purge of water-soluble impurities. Organic by-products are separated from the ketazine layer by distillation. The purified ketazine is then hydrolyzed under pressure (0.2—1.5 MPa (2—15 atm)) to give aqueous hydrazine and methyl ethyl ketone overhead, which is recycled (122). The aqueous hydrazine is concentrated in a final distillation column. [Pg.285]

Reaction of an acid chloride with trimethylsilylacetylene produces an a,P-ethynyl ketone, which on treatment with substituted hydrazines yields a mixture of 1,5- and 1,3-substituted pyrazoles (34). The ratio is dependent on the reaction conditions (eq. 3). [Pg.313]

Organic solutions of HOCl can be prepared in near quantitative yield (98—99%) by extraction of CU -containing aqueous solutions of HOCl with polar solvents such as ketones, nitriles, and esters (131). These organic solutions of HOCl have been used to prepare chlorohydrins (132) and are especially useful for preparation of water-insoluble chlorohydrins. Hypochlorous acid in methyl ethyl ketone has also been used to prepare Ca(OCl)2, by reaction with CaO or Ca(OH)2 (133), and hydrazine by reaction with NH3 (134). [Pg.468]

Hydroxyl Group. The OH group of cyanohydrins is subject to displacement with other electronegative groups. Cyanohydrins react with ammonia to yield amino nitriles. This is a step in the Strecker synthesis of amino acids. A one-step synthesis of a-amino acids involves treatment of cyanohydrins with ammonia and ammonium carbonate under pressure. Thus acetone cyanohydrin, when heated at 160°C with ammonia and ammonium carbonate for 6 h, gives a-aminoisobutyric acid [62-57-7] in 86% yield (7). Primary and secondary amines can also be used to displace the hydroxyl group to obtain A/-substituted and Ai,A/-disubstituted a-amino nitriles. The Strecker synthesis can also be appHed to aromatic ketones. Similarly, hydrazine reacts with two molecules of cyanohydrin to give the disubstituted hydrazine. [Pg.411]

Cyanopyridazines add ammonia, primary and secondary amines and hydroxylamine to give amidines or amidoximes. Substituted amides, thioamides and carboximidates can be also prepared. With hydrazine, 3-pyridazinylcarbohydrazide imide is formed and addition of methylmagnesium iodide with subsequent hydrolysis of the imine affords the corresponding pyridazinyl methyl ketone. [Pg.34]

The repeatedly attempted commercialization of hydrazine synthesis via dialkyldiaziridines required hydrolysis of the latter without the use of stoichiometric amounts of acid. Catalytic amounts of acid, e.g. an acidic ion exchanger, were used in the presence of excess ketone, yielding the azine as an intermediate, which could be hydrolyzed without acid above 100 °C to give hydrazine hydrate and the ketone (62GEP1126395, 71JAP7102008). [Pg.216]


See other pages where Hydrazines ketones is mentioned: [Pg.361]    [Pg.521]    [Pg.521]    [Pg.821]    [Pg.825]    [Pg.826]    [Pg.895]    [Pg.428]    [Pg.929]    [Pg.929]    [Pg.929]    [Pg.93]    [Pg.361]    [Pg.521]    [Pg.521]    [Pg.821]    [Pg.825]    [Pg.826]    [Pg.895]    [Pg.428]    [Pg.929]    [Pg.929]    [Pg.929]    [Pg.93]    [Pg.140]    [Pg.142]    [Pg.166]    [Pg.208]    [Pg.208]    [Pg.263]    [Pg.977]    [Pg.487]    [Pg.134]    [Pg.281]    [Pg.454]    [Pg.311]    [Pg.157]    [Pg.278]    [Pg.82]    [Pg.230]   
See also in sourсe #XX -- [ Pg.108 , Pg.191 ]

See also in sourсe #XX -- [ Pg.1209 , Pg.1210 ]




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Chiral hydrazines, with ketones

Hydrazine epoxy ketones

Hydrazine halo ketones

Hydrazine with aldehydes and ketones

Hydroxy-ketones with hydrazines

Ketones reaction with hydrazines

Ketones with hydrazines

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