Human prostate cell cultures proliferation

F6. Figueroa, J. A., Lee, A. V., Jackson, J. G., and Yee, D., Proliferation of cultured human prostate cells is inhibited by insulin-like growth factor (IGF) binding protein-1 Evidence for an IGF-II... 

Although the influence of lycopene and proliferation of carcinoma cells appears not limited to its ability to modulate Cx43 expression, lycopene as well as its oxidation products have been reported to enhance GJC in cultured cells (Livny et al., 2002 Stahl et al., 2000). Recent data indicate that lycopene may indeed increase connexin-43 expression in human prostate (Kucuk et al., 2001). 

L14. Lui X. H., Wiley, H. S., and Meikle, A. W., Androgens regulate proliferation of human prostate cancer cells in culture by increasing transforming growth factor-a (TGF-a) and epidermal growth factor (EGF)/TGF-a receptor. J. Clin. Endocrinol. Metab. 77, 1472—1478 (1993). 

Preliminary in vitro and animal studies of the effects of silymarin and silybinin have been carried out with several cancer cell lines. In murine models of skin cancer, silybinin and silymarin were said to reduce tumor initiation and promotion. Induction of apoptosis has also been reported using silymarin in a variety of malignant human cell lines (eg, melanoma, prostate, leukemia cells, bladder transitional-cell papilloma cells, and hepatoma cells). Inhibition of cell growth and proliferation by inducing a Gx cell cycle arrest has also been claimed in cultured human breast and prostate cancer cell lines. The use of milk thistle in the clinical treatment of cancer has not yet been adequately studied but preliminary trials are under way. 

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