Human histone deacetylase cells

Buggy JJ, Sideris ML, Mak P, Lorimer DD, McIntosh B, Clark JM (2000) Cloning and characterization of a novel human histone deacetylase, HDAC8. Biochem J 350(R 1) 199-205 Candido EP, Reeves R, Davie JR (1978) Sodium butyrate inhibits histone deacetylation in cultured cells. Cell 14(1) 105-113... 

Gray SG, Ekstrom TJ (2001) The human histone deacetylase family. Exp Cell Res 262(2) 75-83... 

Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th ng J, Han J, Yang XJ (1999) HDAC4, a human histone deacetylase related to yeast HDAl, is a transcriptional corepressor. Mol Cell Biol 19(ll) 7816-7827... 

Gray SG, Ekstrom TJ (2001) The human histone deacetylase family. Exp Cell Res 262 75—83 Greiner D, Bonaldi T, Eskeland R, Roemer E, Imhof A (2005) Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem BioH 143-145 Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem 276(42) 38837-38843... 

Suzuki, T., Nagano, Y, Kouketsu, A., Matsuura, A., Maruyama, S., Kurotaki, M. et al. (2005) Novel Inhibitors of human histone deacetylases design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. Journal of Medicinal Chemistry, 48, 1019—1032. 

He G, Margolis DM (2002) Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HlV-1) by the HlV-1 repressor YYl and HlV-1 activator Tat. Mol Cell Biol 22 2965-2973 Henderson AJ, Calame KL (1997) CCAAT/enhancer binding protein (C/EBP) sites are required for HlV-1 replication in primary macrophages but not CD4-t T cells. Proc Natl Acad Sci USA 94 8714-8719... 

Moscinski L, Atadja P, Bhalla K (2004) Superior activity of the combination of histone deacetylase inhibitor LAQ824 and the FLT-3 kinase inhibitor PKC412 against human acute myelogenous leukemia cells with mutant FLT-3. Clin Cancer Res 10 4991 997 Bali P, Pranpat M, Bradner J, Balasis M, Fiskus W, Guo F, Rocha K, Kumarawsamy S, Boyapalle S, Atadja P, Seto E, Bhalla K (2005) Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90 a novel basis for antileukemia activity of histone deacetylase inhibitors. J Biol Chem 280(29) 26729-26734 Bannister AJ, Schneider R, Kouzarides T (2002) Histone methylation Dynamic or static Cell 109 801-806... 

Dasmahapatra G, Almenara JA, Grant S (2006) Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2. Mol Pharmocol 69 288-298... 

Kwon SH, Ahn SH, Kim YK, Bae GU, Yoon JW, Hong S, Lee HY, Lee YW, Lee HW, Han JW. (2002) Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. J Biol Chem 111 2073-2080. 

Ahn MY, Jung JH, Na YJ, Kim HS. (2008) A natural histone deacetylase inhibitor, Psammaplin A, induces cell cycle arrest and apoptosis in human endometrial cancer cells. Gynecol Oncol 108 27-33. 

Zhu, W.G. and Otterson, G.A. (2003) The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells. Current Medicinal Chemistry Anticancer Agents, 3, 187-199. 

HCG human chorionic gonadotropin HCL hairy cell leukemia Hct hematocrit HCTZ hydrochlorothiazide HD hemodialysis HDAC histone deacetylase Hep hepatitis hepatotox hepatotoxicity HER2 type of cancer gene HF heart failure HFA designation for type of inhalation device Hgb hemoglobin HIT/HITTS heparin-mduced thrombocytopenia... 

George P, et al. Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation 110. of FLT-3. Blood 2005 105 1768-1776. 

Yang X, et al. Transcriptional activation of estrogen receptor a in human breast cancer cells by histone deacetylase inhibition 1. Biochem. Pharmacol. 2000 68 1239-1246. 

Trapoxins were discovered by Itazaki et al. in 1990, from the flingas Helicoma ambiens RF-1023. These compounds exhibit detransformation activity against v-sis oncogene-transformed NIH3T3 cells. Trapoxin A has no effect on human red blood cells, even at a concentration of 250pg/ml and incubation at 37 °C for 2 days Trapoxins are known to inhibit histone deacetylase (HDACl) activity" and trapoxin B has no effect on the stability of HDAC6-PP1 complexes or on tubulin acetylation ... 

Itoh Y et al (2007) Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. J Med Chem 50(22) 5425-5438... 

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