Human glucocorticoid receptor

Human glucocorticoid receptor maps to the long aim of chromosome 5 (5q31-5q32) whereas human mineralocorticoid receptor maps to the long arm of chromosome 4 (4q31.1). 

Hollenberg SM, Weinberger C, Ong ES et al (1985) Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 318 635-641... 

Hollenberg, S.M., Giguere, V, Segui, P. and Evans, R.M. (1987). Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor. Cell 49 39-46. 

Gougat, C., D. Jaffuel, R. Gagliardo, C. Henriquet, J. Bousquet, P. Demoly, and M. Mathieu. 2002. Overexpression of the human glucocorticoid receptor alpha and beta isoforms inhibits AP-1 and NF-kappaB activities hormone independently. J Mol Med 80(5) 309-18. 

Encio IJ, Detera-Wadleigh SD. (1991) The genomic structure of the human glucocorticoid receptor. J Biol Chem. 266, 7182-7188. 

Nunez BS, Vedeckis WV. (2002) Characterization of promoter IB in the human glucocorticoid receptor gene. Mol Cell Endocrinol. 189, 191-199. 

Oakley RH, Sar M, Cidlowski JA. (1996) The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. J Biol Chem. 271, 9550-9559. 

Lewis-Tuffin LJ, Cidlowski JA. (2006) The physiology of human glucocorticoid receptor beta (hGRbeta) and glucocorticoid resistance. Ann N Y Acad Sci. 1069,1-9. 

Karl M, Lamberts SW, Detera-Wadleigh SD, et al. (1993) Familial glucocorticoid resistance caused by a sphce site deletion in the human glucocorticoid receptor gene. J Clin Endocrinol Metab. 76, 683-689. 

Majnik J, Patocs A, Balogh K, Toth M, Racz K. (2004) A rapid and simple method for detection of Asn363Ser polymorphism of the human glucocorticoid receptor gene. J Steroid Biochem Mol Biol. 92, 465-468. 

Lewis, D.F.V. et al. (2002) Molecular modelling of the human glucocorticoid receptor (hGR) ligand-binding domain (LBD) by homology with the human estrogen receptor a (hERa) LBD quantitative structure-activity... 

Silva CM, Cidlowski JA. The effect of oxidation/reduction on the charge heterogeneity of the human glucocorticoid receptor. J Steroid Biochem Mol Biol 1992 41 1-10. 

In fact, when the primary structure of the first steroid receptor, the human glucocorticoid receptor [79] was deduced from the nucleotide sequence the homology of this central region with the product of the v-erb-A oncogene of the avian erythroblastosis virus immediately became conspicuous [80]. This similarity subsequently led to the identification of c-erb-A, the cellular counterpart of v-erb-A, as the gene for a thyroid hormone receptor [92,93]. The kinship amongst these sequences has also greatly helped to identify cDNA clones for other steroid hormone receptors. 

Dahlman-Wright K, et al. Dehneation of a small region within the major transactivation domain of the human glucocorticoid receptor that mediates transactivation of gene expression. Proc. Natl. Acad. Sci. U.S.A. 1994 91 1619-1623. Hadzopoulou-Cladaras M, et al. Functional domains of the nuclear receptor hepatoc)4e nuclear factor 4. J. Biol. Chem. 1997 272 539-550. 

Okuyama-Tamura, M., M. Mikuni and I. Kojima. Modulation of the human glucocorticoid receptor function by antidepressive compounds. Neurosci. Lett. 342 206-210, 2003. 

Lane SJ, Arm JP, Staynov DZ, et al Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid-resistant bronchial asthma. Am J Respir Cell Mol Biol 1994 11 42-48. (NC)... 

Lu NZ, Cidlowski JA The origins and functions of multiple human glucocorticoid receptor isoforms. Ann NY Acad Sci 2004 1024 102-123. 

M.V. Govindan, M. Devic, S. Green, H. Gronemeyer, P. Chambon, Cloning of the human glucocorticoid receptor cDNA, Nucleic Acids Res. 1985, 13, 8293-8304. 

Flogger P, Rohdewald P (1994). Binding kinetics of fluticasone propionate to the human glucocorticoid receptor. Steroids. 59 597-602. 

Binding affinity to human glucocorticoid receptors in vitro relative to dexamethasone. Dati HW. Establishing a therapeutic index for the inhaled corticosteroids. Part 1 Pharmacokine pharmacodynamic comparison of the inhaled corticosteroids. J Allergy Clin Immunol 1998 102 S36-S51. 

EliardPH, Rousseau GG (1984) Thermodynamics of steroid binding to the human glucocorticoid receptor. Biochem J 218 395-404. 

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