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Human brain-derived neurotrophic factor

Bamthouse, K.A., Trompeter, W., Jones, R., Rupp, R., and Cramer, S.M., Ion-exchange displacement chromatography scale-up and displacer clearance for recombinant human brain-derived neurotrophic factor, LC-GC, 17(11), 1028, 1999. [Pg.138]

LeBel, C.P and Foss, J.A., Use of a rodent neurotoxicity screening battery in the preclinical safety assessment of recombinant-methionyl human brain-derived neurotrophic factor,... [Pg.287]

Bamthouse et al. [33] demonstrated the separation of recombinant human-brain-derived neurotrophic factor (rHuBDNF) expressed in Escherichia coli in cation exchange chromatography using... [Pg.315]

Waters SP-8HR (strong cation exchange, 8 /r particles) Linear amines (spermine, spermidine, triethylene tetramine, diethylene triamine, tetraethylene pentamine) low molecular weight branched aromatic and nonaromatic dendrimers (e.g., PETMA4, DPE-TMA6, PE-DMABzCl4) rHu-BDNF (recombinant human brain-derived neurotrophic factor) 51... [Pg.386]

Sunasara, K. M., Cramer, S. M., Hauer, C. R., Rupp, R. G., and Shoup, V. A. (1999). Characterization of recombinant human brain-derived neurotrophic factor variants. Arch. Biochem. Biophys. 372(2), 248-260. [Pg.415]

Wellmer A, Misra VP, Sharief MK, Kopelman PG, Anand P. 2001. A double-blind placebo-controlled clinical trial of recombinant human brain-derived neurotrophic factor (rhBDNF) in diabetic polyneuropathy. J Peripher Nerv Syst 6 204-210. [Pg.248]

Narhi, L.O., Rosenfeld, R., Talvenheimo, J., Prestrelski, S.J., Arakawa, T., Lary, J.W., Kolvenbach, C.G., Hecht, R., Boone, T., Miller, J.A. and Yphantis, D.A. (1993) Comparison of the biophysical characteristics of human brain-derived neurotrophic factor, neurotrophin-3 and nerve growth factor. J. Biol. Chem. 268 13309-13317. [Pg.215]

Laroute V, Lefebvre HP, Costes G, Toutain PL (1999) Measurement of glomerular filtration rate and effective renal plasma flow in the conscious beagle dog by single intravenous bolus of iohexol and p-aminohippuric acid. J Pharmacol Toxicol Methods 41 17-25 LeBel CP, Foss JA (1996) Use of a rodent neurotoxicity screening battery in the preclinical safety assessment of recombinant-methionyl human brain-derived neurotrophic factor. Neurotoxicology 17 851-863... [Pg.377]

Figure 2.8. Scheme of a chimeric peptide with examples for each of the distinct domains. 0X26, anti-rat transferrin receptor monoclonal antibody (mAh) 84-15, anti-human insulin receptor mAh cHSA, cationized human serum albumin VIP, vasoactive intestinal polypeptide DALDA, dermorphin analogue NGF, nerve growth factor BDNF, brain-derived neurotrophic factor PNA, peptide nucleic acid (3-gal, (3-galactosidase. [Pg.42]

The role of neurotrophins in the pathogenesis of allergic disease and asthma has been appreciated only recently. Neurotrophins are a family of growth factors that have common receptors and physiologic effects and are the principal regulators of neuronal activity, differentiation and maintenance. In humans, there are at least four defined neurotrophins also termed NGFs. These polypeptides include NGF, neurotrophin 3 (NT-3), neurotrophin 4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF). They all act on a common group of tropomyosin-related tyrosine kinase (Trk) receptors. Neurotrophin receptors are expressed in the neurons of both the central and peripheral nervous systems. [Pg.139]

Mucke L, MasUah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Fotss-Petter S, Pietropaolo M, Mallory M, Abraham CR (1994) Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice. Brain Res 666 151-167 Nacmias B, Piccini C, Bagnoli S, Tedde A, Cellini E, Bracco L, Sorbi S (2004) Brain-derived neurotrophic factor, apolipoprotein E genetic variants and cognitive performance in Alzheimer s disease. Neurosci Lett 367 379-383... [Pg.603]

Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, Weinberger DR. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J. Neurosci. 2003 23 6690-6694. [Pg.2259]

Bachis A, Major EO, Mocchetti I (2003) Brain-derived neurotrophic factor inhibits human immunodeficiency virus-l/gpl20-mediated cerebellar granule cell death by preventing gpl20 internalization. J Neurosci 23 5715-5722. [Pg.198]

Soontomniyomkij V, Wang G, Pittman CA, Wiley CA, Achim CL (1998) Expression of brain-derived neurotrophic factor protein in activated microglia of human immunodeficiency virus type 1 encephahtis. Neuropathol Appl Neurobiol 24 453 60. [Pg.203]

Yamamoto, H. and Gurney, M.E. (1990) Human platelets eontain brain-derived neurotrophic factor. J. Neurosci. 10 3469-3478. [Pg.217]

Pardridge, W.M., Y.-S. Kang, and J.L. Buciak, Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery. Pharmaceutical Research, 1994, 11(5), 738-746. [Pg.232]

Murer MG, Yan Q, Raisman-Vozari R (2001) Brain-derived neurotrophic factor in the control human brain, and in Alzheimer s disease and Parkinson s disease. Prog Neurobiol 63 71-124... [Pg.317]

Nishino S, Ohtamo K, Numata Y, Sato T, Nakahata N, Kurita M. Divergent effects of lithium and sodium valproate on brain-derived neurotrophic factor (BDNF) production in human astrocytoma cells at therapeutic concentrations. Prog Neuropsychopharmacol Biol Psychiatry 2012 39(l) 17-22. [Pg.35]


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See also in sourсe #XX -- [ Pg.297 ]




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