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Neurotoxicity screen

Many of the studies done in safety assessment are multiple endpoint screens. Such study types as a 90-day toxicity study or immunotox or neurotox screens are designed to measure multiple endpoints with the desire of increasing both sensitivity and reliability (by correspondence-correlation checks between multiple data sets). [Pg.118]

TABLE 7.6. FDA Draft Criteria for a Neurotoxicity Screen as a Component of Short-Term and Subchronic Studies... [Pg.252]

Sheets LP. 1993a. An acute oral neurotoxicity screening study with technical grade disulfoton (DI-SYSTON) in rats. Study No. 92-412-OB, Report No. 103992. Miles Inc. Agriculture Division. Toxicology, Stilwell, Kansas. [Pg.195]

LeBel, C.P and Foss, J.A., Use of a rodent neurotoxicity screening battery in the preclinical safety assessment of recombinant-methionyl human brain-derived neurotrophic factor,... [Pg.287]

The Neurotoxicity Screening Battery test guideline (OPPTS 870.6200) consists of a functional observational battery, motor activity, and neuropathology. The test battery is not intended to provide a complete evaluation of neurotoxicity, and additional functional and morphological evaluation may be necessary to assess completely the neurotoxic potential of a chemical. [Pg.132]

Sheets LP, Hamilton BF, Sangha GK, et al Subchronic neurotoxicity screening studies with six organophosphate insecticides an assessment of behavior and morphology relative to cholinesterase inhibition. Fundam Appl Tox/ro/35(1) 101-19, 1997... [Pg.65]

USEPA (U.S. Environmental Protection Agency). Health Effects Test Guidelines. OPPTS 870.6200. Neurotoxicity screening battery. Washington, DC USEPA 1998. [Pg.149]

McConnell ER, McClain MA, Ross J, Lefew WR, Shafer TJ (2012) Evaluation of multiwell microelectrode arrays for neurotoxicity screening using a chemical training set. Neurotoxicology 33 1048-1057... [Pg.145]

Mattsson, J. L., Wilmcr, J. W., Shankar, M. R, Berdasco, N. M., Crissinan, J. W, Mauris.sen, J. P., and Bond, D. M. (1996). Single-dose and 13-week repeated-dose neurotoxicity screening studies of chlorpyrifos insecticide. Food Chem. Toxicol. 34, 393-405. [Pg.358]

Sheei.t, L. P., Hamilton, B. F,. Sangha, G. K.. and Thys.scn. J. H. (1997). Subchronic neurotoxicity. screening studies with. six organophosphate inseciieides An assessment of behavior and morphology relative to cholinesterase inhibition. Fimdom. Appl. Toxicol. 35, 101-119. [Pg.360]

US Environmental Protection Agency (1998) Neurotoxicity screening battery. EPA 712-C-98-238. In Health effects test guidelines Neurotoxicity screening battery. EPA 712-C-98-238. Washington, DC... [Pg.109]

Laroute V, Lefebvre HP, Costes G, Toutain PL (1999) Measurement of glomerular filtration rate and effective renal plasma flow in the conscious beagle dog by single intravenous bolus of iohexol and p-aminohippuric acid. J Pharmacol Toxicol Methods 41 17-25 LeBel CP, Foss JA (1996) Use of a rodent neurotoxicity screening battery in the preclinical safety assessment of recombinant-methionyl human brain-derived neurotrophic factor. Neurotoxicology 17 851-863... [Pg.377]

See other pages where Neurotoxicity screen is mentioned: [Pg.77]    [Pg.78]    [Pg.397]    [Pg.27]    [Pg.127]    [Pg.131]    [Pg.395]    [Pg.142]    [Pg.143]    [Pg.143]    [Pg.147]    [Pg.148]    [Pg.2663]    [Pg.2697]    [Pg.47]    [Pg.216]   
See also in sourсe #XX -- [ Pg.252 ]



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