Hormone abuse

Bhasin S, Wallace W, Lawrence JB, Lesch M. Sudden death associated with thyroid hormone abuse. Am J Med 1981 71(5) 887-90. 

Watching the world become awash in steroid sex hormones, abused in animals and humans, Lopez de Alda et al. (2003) felt the need to review LC-MS and LC-MS-MS methods for the determination of these and other analytes in the aquatic environment. 

B. Euthyroid persons and children appear to have a high tolerance to the effects of an acute overdose. Patients with preexisting cardiac disease and those with chronic overmedication have a lower threshold of toxicity. Sudden deaths have been reported after chronic thyroid hormone abuse in healthy adults. 

The bodybuilding steroids include testosterone and related anabolic steroids. Anabolic substances promote secondary male sex characteristics that improve athletic performance by increasing muscle mass and promoting a fast recovery between workouts. Illicit steroids can be synthesized or diverted and are available via mail order on the Internet. Since these substances are sex hormones, abuse can lead to excessive aggression (" roid rage"), the development of male characteristics in females, liver damage, sterility, acne, and increased cholesterol levels. 

Holt, R.I., Erotokritou-Mulligan, I., and Sonksen, EH. (2009) The history of doping and growth hormone abuse in sport. Growth Hormone and IGF Research, 19,320-326. 

Holt, R.I.G. (2009) Detecting growth hormone abuse in athletes. Drug Testing and Analysis, 1, DOI 10.1002/dta.l059. 

First described in 1926 by Perrin [16], the theory was greatly expanded by Weber [17], who developed the first instrumentation for the measurement of FP. Dandliker [18] expanded FP into biological systems such as antigen-antibody reactions and hormone-receptor interactions. Jolley [19] developed FP into a commercial system for monitoring of therapeutic drug levels and the detection of drugs of abuse in human body fluids. 

Miscellaneous (immobility, poor diet, laxative abuse, hormonal disturbances)... 

The list of new chemicals whose presence in the environment represents an ascertained or potential risk is sizeable and broadly contains resins, plastics, and plastic additives (e.g., plasticizers and flame retardants) pharmaceuticals and personal care products (e.g., disinfectants, fragrances, sunscreens, antibiotics, drugs of abuse, and natural and synthetic hormones) detergents and other cleaning... 

Stressful early life events, involving abuse or neglect, can have a life-long influence on the stress response, and lead to elevated levels of allostatic load for the lifespan. Overactivity of the stress hormone axis has been linked to prenatal stress or poor maternal care in rodent models, and this overactivity contributes to increased rates of brain and body aging [39]. 

Becker IB, Beer ME, et al (1984) Striatal dopamine release stimulated by amphetamine or potassium influence of ovarian hormones and the light-dark cycle. Brain Res 311(1) 157-160 Becker IB, Molenda H, et al (2001) Gender differences in the behavioral responses to cocaine and amphetamine. Implications for mechanisms mediating gender differences in drug abuse. Ann N Y Acad Sci 937 172-187... 

Benzene is a chemical species called an aromatic hydrocarbon. It turns out that rings such as the one in benzene are found in the majority of the molecules that we encounter moving forward hormones, neurotransmitters, antibiotics, amino acids, nucleic acids, many pharmaceutical products, carcinogens, substances of abuse, and so on. So it is worthwhile to get some feeling for what is going on with benzene and its relatives. 

Certain medicines may not be imported under the personal importation provisions, including drugs of abuse, such as narcotics, amphetamines and psychotropic substances, and anabolic substances, androgenic steroids and treatments for alcohol and drug addiction. There are also controls over certain other medicines including erythropoietin, growth hormones and gonadotrophins. 

Kaufman, J., Birmaher, B., Perel, J., Dahl, R.E., Moreci, P., Nelson, B., et al. (1997) The corticotropin-releasing hormone challenge in depressed abused, depressed nonabused, an normal control children. Biol Psychiatry 42 669-679. 

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