HL60 cell

Abundance of Na /H exchanger transcripts in vascular smooth muscle and HL60 cells is increased by serum, phorbol esters, fibroblast growth factor and platelet-derived growth factor [78,79]. The increase in NHE-1 mRNA levels in PMA-treated HL60 cells is due to increased gene transcription. 

M. R., Wardman, P., Nitric oxide involvement in the toxicity of hydroxyguanidine in leukaemia HL60 cells, Br. J. Cancer Suppl. 27 (1996),... 

Cockcroft, S., Stutchfield, J. (1989). ATP stimulates secretion in human neutrophils and HL60 cells via a pertussis toxin-sensitive guanine nucleotide-binding protein coupled to phospholipase C. FEBS Lett. 245,25-9. 

Stutchfield, J., Cockcroft, S. (1990). Undifferentiated HL60 cells respond to extracellular ATP and UTP by stimulating phospholipase C activation and exocytosis. FEBS Lett. 262,256-8. 

In contrast to c-Jun, phosphorylation of the tumor suppressor p53 by CSN-associated kinases targets the protein for degradation by the Ub system [35]. For p53 stability, modification on Thrl55 is most important as shown by mutational analysis [35] and by using different p53 peptides [31]. Mutation of Thrl55 to Val led to stabilization of the transiently expressed p53 mutant in HeLa as well as in HL60 cells [35]. Inhibitors of CSN-associated kinases such as curcumin [18] caused stabilization of cellular p53 followed by massive cell death [35]. 

Boggs, K., Rock, C.O., and Jackowski, S., 1998, The antiproliferative effect of hexadecyl-phosphochohne toward HL60 cells is prevented by exogenous lysophosphatidylchohne. Biochim. Biophys. Acta, 1389 1-12... 

Many intracellular targets of sphingosine that may contribute to its apoptotic and anti-proliferative effects have been identified (Figure 2). These include proteins of the bcl-2 family, the retinoblastoma gene product, several enzymes and its ability to interact with DNA (reviewed by Alessenko, 2000). For example, sphingosine-induced apoptosis of HL60 cells correlated with reduced expression of the cell survival protein bcl-2... 

Griffiths G, Garrone B, Deacon E, Owen P, Pongracz J, Mead G, Bradwell A, Watters D, Lord J (1996) The polyether bistratene A activates protein kinase C-delta and induces growth arrest in HL60 cells. Biochem Biophys Res Commun 222 802-808... 

Kiss Z, Deli, E, Vogier WR, Kuo )F (1987) Antileukemic agent alk ysophospholipid regulates phosphorylation of distinct proteins in HL60 and K562 ceUs and differentiation of HL60 cells promoted by phorbol ester. Biodiem Biophys Res Common 142 661-666... 

Ma LD, Marquardt D, Takemoto L., Center MS (1991) Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine. J Biol Chem 266 5593-5599... 

Shoji M, Raynor RL, Fleer EA, Eibl H, Vogler WR, Kuo JF (1991) Effects of hexade-cylphosphocholine on protein kinase C and TPA-induced differentiation of HL60 cells. Lipids 26 145-149... 

Staats), Marquardt D, Center MS (1990) Characterization of a membrane-associated protein Idnase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein. J Biol Chem 265 4084-4090 Stabel S, Parker PJ (1991) Protein kinase C. Pharmac Ther 41 71-95 Stabel S (1994) Protein kinase C - an enzyme and its relatives. Sem Cancer Biol 5 277-284... 

Stone RM, Sariban E, Pettit GR, Kufe DW (1988) Biyostatin 1 activates PKC and induces monocytic differentiation of HL60 cells. Blood 72 208-213. 

Kolachana, P, Subrahmanyam, VV, Meyer, K.B.. Zhang, L. Smith, M.T. (1993) Benzene and its phenolic metabolites produce oxidative damage in HL60 cells in vitro and in the bone marrow in vivo. Cancer Res., 53, 1023-1026... 

Phenol was reported to induce DNA oxidative damage in human promyelocytic HL60 cells and to inhibit repair of radiation-induced chromosomal breaks in human leukocytes (Morimoto et al., 1976). However, it only slightly inhibited DNA repair synthesis and DNA replication synthesis in WI-38 human diploid fibroblasts (Poirier et al., 1975). 

Toluene can activate cyclin-dependent kinase 2 in rat liver epithelial (RLE) and HL60 cells in vitro and it also causes hyperphosphorylation of p53 and pRB105 in these cells. These activities are shared with benzene but, unlike benzene, toluene did not increase the p53-DNA site-specific binding in RLE cells (Dees Travis, 1994 Dees et al., 1996). 

Determination of in vitro growth inhibitory activity of several thieno[3,4-d]pyrimidine C-nucleosides against L1210-C1, sarcoma 180, and HL60 cell lines indicated that 4-amino-7-/3-D-ribofuranosylthieno[3,4-t/Jpyrimidine 377 is by far the most cytotoxic, with IC50 values of 0.0046, 0.015 and 0.0092 respectively (93JHC509). 

Kanayama N, Maehara K, Suzuki M, Fujise Y, Terao T. The role of chondroitin sulfate chains of urinary trypsin inhibitor in inhibition of LPS-induced increase of cytosolic free Ca2+ in HL60 cells and HUVEC cells. Biochem Biophys Res Commun 1997 238 560-564. 

Boulay, F., Mery, L., Tardif, M., Brouchon, L., and Vignais, P. (1991) Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL60 cells. Biochemistry 30,2993-2999. 

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