Histological effects

This red color has not yet been approved for uses in foods or cosmetics. However, studies on rats fed with the dried biomass have not revealed any adverse growth or histological effects. Future efforts should thus be devoted toward obtaining official approval of use of the color in foodstuffs for human consumption. 

Kendall, R.J., H.P. Veit, and P.F. Scanlon. 1981. Histological effects and lead concentrations in tissues of adult male ringed turtle doves that ingested lead shot. Jour. Toxicol. Environ. Health 8 649-658. 

Hall, K.C. and D.R. Bellwood. 1995. Histological effects of cyanide, stress and starvation on the intestinal mucosa of Pomacentrus coelestis, a marine aquarium fish species. Jour. Fish Biol. 47 438-454. 

Severe adverse effects of 60 mg Se/kg ration on survival, growth, and liver histology effects exacerbated by the addition of boron... 

Renal Effects. Urinary parameters (blood urea nitrogen, pH, osmolality, voliune, protein, sugar, and sediment) were normal in female dogs exposed to 3,3 -dichlorobenzidine (10.4 mg/kg/day) throughout a 7-year study in which female dogs were exposed to 10.4 mg/kg/day 3,3 -dichlorobenzidine. At necropsy, no histological effects to the kidneys were reported in any of the dogs (Stula et al. 1978). 

Continuous feeding of 1% (10,000 ppm) in the diet of rats for 105 days caused no effect 2% in the diet caused growth inhibition, but no histologic effects were observed. ... 

Table 5 Frequency distribution of numbers of flounder livers in histological effect classes. Explanation of the classes in the main text. ...

Pfeiffer N, Grierson I, Goldsmith H, Hochgesand D, Winkgen-Bohres A, Appleton P. Histological effects in the iris after 3 months of latanoprost therapy the Mainz 1 study. Arch Ophthalmol 2001 119(2) 191-6. 

Bhawan, J., Short- and long-term histologic effects of topical tretinoin on photodamaged skin, Ini. J. Dermatol., 37, 286, 1998. 

Bing, R.J., J.S.Sarma, R.Weishaar, A.Rackl, and G.Pawlik. 1980. Biochemical and histological effects of intermittent carbon monoxide exposure in cynomolgus monkeys (Macaca fascicularis) in relation to atherosclerosis. J. Clin. Pharmacol. 20(8- 9) 487-499. 

Bach N, Thung SN, Schaffner F. The histologic effects of low-dose methotrexate therapy for primary biliary cirrhosis. Arch Pathol Lab Med 1998 122(4) 342-5. 

In the last case, because of the similarity of the chnical, laboratory, and histological effects of omeprazole and lansoprazole, as previously reported, the authors concluded that the reaction in the second patient might have been caused by the proton pump inhibitor rather than terbinafine. 

The histological effects of AHAs also reach the dermis. Moy showed that fibroblast cultures in a glycolic environment produced up to 10 times as much hydroxyproKne (a precursor of collagen) than when cultivated in a normal saline environment. A practical problem is that AHAs do not normally reach the dermis (because, apart from Easy Phytic solution, they are neutralized before they can penetrate that far) and therefore cannot directly stimulate fibroblasts as well as they did in this in vitro study. 

It is still very difficult, however, to tally the clinical results and the histological changes of the different types of peels the formulations, adjuvants and concentrations are different, as are the methods of preparation and application of the various active agents used. Each patient has different cell characteristics, either in the quality or the quantity of phospholipids, sterols and proteins embedded in the cell membranes. Doctors are guided by their own experiences and follow the application protocol they have gradually developed in the course of their practice. This disparity makes it difficult to compare the results of different studies. Some general principles can, however, be drawn we can consider that all peels produce comparable histological effects. The differences arise from the extent of the inflammation caused and how this inflammation is controlled, as well as the relative depth reached. As far as... 

R4. Reid, J., and Jarrett, A., Enzymatic and histologic effects of a standard stimulus to the skin of normals and the clinically normal skin of psoriatics. Arch. Dermatol. 96, 532-640 (1967). 

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