High-protein diet, effect

The toxic effects of hydrocarbons are well established. Injection of 150 mg/kg of bromobenzene into rats produces acute centrolobulm- hepatic necrosis within 48 hours (Koch-Weser el al., 1952). The toxieitj is related to the general nutiitional state, ilethionine and cj stine, or a high protein diet, effectively combat the effects of the hydrocarbons. Koch-Weser suggests the liver damage is due to removal of cysteine and methionine, since p-dibromobenzene and p-bromochlorobenzene, which do not form mercapturic acids, do not cause hepatic lesions while w-chloro-... 

Lnczak-Szcznrek, A., and Flisinska-Bojanowska, A., 1977. Effect of high-protein diet on glycolytic processes in skeletal muscles of exercising rats. Journal of Physiology and Pharmacology 48 119—126. 

Trilok, G. and Draper, H.H. 1989a Effect of a high protein diet on acid-base balance in adult rats. 

Since the early 1970 s, research has been directed at identifying the mechanism by which the calciuria is induced. Attention was given first to the question of whether the elevated urinary calcium excretion was caused by an increase in the intestinal absorption of calcium. Results of calcium balance studies in human subjects showed that protein ingestion either had no effect on calcium absorption (4) or that the effect was insufficient to account for the calciuria (5j. Consequently, negative calcium balance is a frequent observation in human studies when high protein diets are fed, and this situation is not improved by high calcium intakes (4 ). 

Table IV. Postprandial Effects of Ca and P Levels in High Protein Diets on Urinary Calcium Excretion of Men...

Drug/Food interactions Theophylline elimination is increased (half-life shortened) by a low carbohydrate, high protein diet, and charcoal broiled beef (due to a high polycyclic carbon content). Conversely, elimination is decreased (prolonged half-life) by a high carbohydrate low protein diet. Food may alter the bioavailability and absorption pattern of certain sustained-release preparations. Some sustained-release preparations may be subject to rapid release of their contents when taken with food, resulting in toxicity. It appears that consistent administration in the fasting state allows predictability of effects. 

A high-protein diet is of debatable value. Since increased protein intake seems to have a theoretic adverse effect on renal function in some disease... 

The first human experiments which suggested a toxic effect of ammonia in disease were done by Van Caulaert. The revival and extension of this work by the group led by Davidson (G2) in the Boston City Hospital has stimulated widespread interest in ammonia as a factor in the production of mental symptoms in liver disease. The ability of various factors, such as urea feedings, high-protein diet, cation resins in the ammonia cycle, and amino acids, to induce symptoms of coma in patients with liver disease (G2, M3, M4, P7, S8) made it quite clear that ammonia was associated with the symptom complex called hepatic coma. The severe toxicity of ammonia in animals and the ability of intravenous or oral ammonium salts to provoke episodes of impending liver coma tended to substantiate the clinical impressions. Rapid confirmation of these observations was furnished by the experiments of other groups (Bll, C2, E2, FI). 

Experiments in rats have shown that simultaneous treatment with DEHP and vitamins C and E prevents the testicular atrophy observed when rats are treated with DEHP alone (Ishihara et al. 2000). However, none of these theoretical interventions have been studied in DEHP-poisoned patients, and they are not currently recommended in human clinical medicine. The effect of a low protein diet on toxicity of DEHP in rats was addressed in a study by Tandon et al. (1992). Animals maintained on a low protein diet were more susceptible to DEHP-induced testicular damage than animals receiving a normal protein diet. However, the effects of a high protein diet were not examined and potential interactions of diet and DEHP toxicity have not been studied in humans. 

Usage 50-100 mg taken orally each morning for 10-14 consecutive days. The effects are cumulative. Results are most noticeable when combined with high protein diet, abundant vitamin C and balanced B complex intake, and adequate calcium and magnesium consumption. For more pronounced and immediate effects as a cerebral and CNS stimulant,... 

T. Purshottam, and R.K. Srivatsava, Effects of high-fat and high-protein diets on toxicity of parathion and dichlorvos. Arch. Environ. Health. 39 425, 1984. 

High-protein diets decrease the bioavailability of theophylline (high-carbohydrate diets increasing the bioavailability of theophylline) and reduce the effects of levodopa and methyldopa (from competition of amino acids for absorption),... 

The following study demonstrates the effect of dietary protein on uric acid. In the study, human subjects consumed diets containing no protein, normal levels of protein, and extremely high levels of protein. The diets were chemically defined and did not contain purines. The protein-free diet supplied 0.9 g N/day. The normal-protein diet supplied 13 g l>J/day, The extremely high-protein diet supplied 62 g N/day. The feeding trials were 2 weeks in duration. The norma I-protein diet contained 90 g of egg albumin, which was supplemented with 162 g of soy protein plus 156 g of casein in the high-protein diet. 

Free sulfate occurs in the plasma at concentrations of 1 to 2 mAf, The sulfate in the plasma and glomerular filtrate has been a concern for those interested in calcium status. Consumption of high-protein diets leads to increases in urinary calcium levels. This effect has been attributed, in part, to the catabolism of sulfur amino adds to yield free sulfate. The sulfate forms a complex with the calcium in... 

Spencer, II., Kramer, L., DeBartolo, M., Norris, C, and Qsis, D. (1983). Further studies of the effect of a high protein diet as meat on calcium metabolism. Am. J. Clin. Nufr. 37, 924r-929,... 

Food can affect both the absorption and the clearance of theophylline. One study showed that the absorption of a modified-release formulation of theophylline was very slow after an overnight fast, in contrast to absorption after a test meal (86). The effect may be dose-related. More specifically, dietary protein significantly affects theophylline clearance a low-protein diet reduces theophylline clearance and a high-protein diet increases it. The implications for clinical practice have not been elaborated, but dietary extremes are contraindicated in patients taking theophylline (51). 

If you re attempting to lose weight by following a high-protein diet such as Atkins or South Beach, you should know that these diets are pretty much a sure-fire way to unbalance your pH and make you vulnerable to disease. While they may help some people with short-term weight loss, they create an extreme state of acidity, and the rebound effect will ensure that you regain the weight you lost, and possibly more. 

Fleming, R.M. The Effects of High-Protein Diets on Coronary Blood Flow. Angiology 51, no. 10 (October 2000) 817-26. 

Table II. Effect of Supplementing a High-Protein Diet...

Dietary protein may also be able to moderate the effect of dietary phosphorus on zinc utilization. Greger Snedeker (54) observed that human subjects absorbed more zinc when fed a high protein diet with a moderate level of phosphorus than when fed a high protein diet with a high level of phosphorus. This effect of phosphorus was not seen when low levels of protein were fed. 

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