Beef, charcoal-broiled

Drug/Food interactions Theophylline elimination is increased (half-life shortened) by a low carbohydrate, high protein diet, and charcoal broiled beef (due to a high polycyclic carbon content). Conversely, elimination is decreased (prolonged half-life) by a high carbohydrate low protein diet. Food may alter the bioavailability and absorption pattern of certain sustained-release preparations. Some sustained-release preparations may be subject to rapid release of their contents when taken with food, resulting in toxicity. It appears that consistent administration in the fasting state allows predictability of effects. 

Diet. Diet is shown to affect the absorption, metabolism, and response to many drugs.12,30 Animal and human studies indicated that the total caloric input as well as the percentage of calories obtained from different sources (carbohydrates, proteins, and fats) influence drug pharmacokinetics.17,26 Specific dietary constituents such as cruciferous vegetables and charcoal-broiled beef can also alter drug metabolism.17... 

In humans it has been demonstrated that increasing the ratio of protein to carbohydrate in the diet stimulates oxidation of antipyrine and theophylline, while changing the ratio of fat to carbohydrate had no effect. In related studies, humans fed charcoal-broiled beef (food high in polycyclic hydrocarbon content) for several days had significantly enhanced activities of CYPs 1A1 and 1A2, resulting in enhanced metabolism of phenacetin, theophylline, and antipyrine. Studies of this nature indicate that there is significant interindividual variability in these observed responses. 

The significance of polycyclic aromatic hydrocarbons (PCH) formed in charcoal-broiled beef has been publicized with respect to the ability of these substances to alter the fate of drugs in the... 

Pantuck, E.J., et al. Effect of charcoal-broiled beef on phen-acetin metabolism in man. Clin Pharmacol Therap, 1979 25 88-95... 

Table III. Dimethylhydrazine-induced tumors in rats fed lyophilized charcoal broiled beef, raw beef or soybean protein...

Conney AH, Pantuck EJ, Hsiao K-C, Garland WA, Anderson KE, Alvares AP, Kappas A. 1976. Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. Clin. Pharmacol. Ther. 20 633 12... 

Kappas A, Alvares AP, Anderson KE, Pantuck EJ, Pantuck CB, Chang R, Conney AH. 1978. Effect of charcoal-broiled beef on antipyrine and theophylline metabolism. Clin. Pharmacol. Ther. 23 445-50... 

Hecht SS, Grabowski W, Groth K. 1979. Analysis of faeces for B[a]P after consumption of charcoal-broiled beef by rats and humans. Food Cosmet Toxicol 17 223-227. 

Benzoflavone, ciprofoxacin, ellipticine, flavonoids (apigenin, naringenin, quercetin, etc.), fluoxamine, flurafylline, a-naphthoflavone, phenacetin Benzo[a]pyrene, charcoal-broiled beef, cigarette smoke, cruciferous vegetables, dihydralazine, 3-methylcholanthrene... 

Charcoal-broiled beef Cigarette smoke Cruciferous vegetables Omeprazole... 

Anderson KE, Schneider J, Pantuck EJ, Pantuck CB, Mudge GH, Welch RM, Coraiey AH, Kappas A. Acetaminophenmetabolism in subjects fed charcoal-broiled beef CfinPhamiaco/ r/ter (1983) 34,369-74. 

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