Tacrine hydrochloride

Sumartriptan tablets/injection Tacrine hydrochloride Nitroscanate Taurolidine 2% or 0.5% Teicoplanin for... 

Dose. Tacrine hydrochloride has been given in doses of 10 to 60 mg, intravenously. 

Codeine Hydrochloride Dequalinium Acetate Fluorometholone Hexamethonium Bromide Riboflavine Stilbazium Iodide Mianserin Hydrochloride Tacrine Hydrochloride Diclofenac Sodium Vinblastine Sulphate Cyclizine Hydrochloride Amiloride Hydrochloride Protoveratrine B Meclofenamate Sodium 5-Methyltryptamine Hydrochloride Dicoumarol Mebendazole Pipradrol Hydrochloride Carbenoxolone Flucytosine Phanquone Phenytoin... 

Chemical and Physical Properties Tacrine has an empirical formula of C13H14N2 HCl and a molecular weight of 234.73. Tacrine hydrochloride represents a white solid that is readily water soluble and soluble in organic solvents. This formulation has a melting point of 283-284°C and a bitter taste. 

Eirst Horizon Pharmaceutical Corporation. Cognex (tacrine hydrochloride) package insert. Roswell, GA, 2000. 

Cognex (Tacrine hydrochloride). First Horizon Pharmaceutical Corp. US Prescribing information, January 2002. 

Of the acetylcholinesterase inhibitors, tacrine, methoxy-tacrine, metrifonate, donepezil hydrochloride, and rivastigmine are used in the treatment of Alzheimer s disease. In 12-30% of patients with Alzheimer s disease, tacrine causes an increase in hepatic transaminase activity. Abdominal adverse effects are very frequent, for example nausea, anorexia, diarrhea. The peripheral cholinomimetic effects of tacrine occur in a very high proportion of patients, probably the majority. The hepatic effects seem to be such that the use of these new (and in some cases still experimental) drugs would not be justified in... 

Clinically important, potentially hazardous interactions with aspirin, boswellia, ciprofibrate, diuretics, methotrexate, NSAIDs, oxycodone hydrochloride, salicylates, tacrine, tacrolimus, urokinase... 

Tacrine (9-amino-1,2.3,4-tetrahydroacride hydrochloride hydrate) is a cholinesterase inhibitor of potential use in Alzheimer s disease, based on the ability to facilitate cholinergic function in the CNS via direct stimulation of M- and N-receptors through inhibition of AChE (Avery et al, 1997 Newhouse et uL, 1997). Since ACh plays a fundamental role in visual function (Famiglictti, 1983 Hutchins, 1987 Ross et al, 1985), and because some visual. symptoms and optic nerve degeneration occur in Alzheimer s disease patient-s (Hinton et al., 1986) and the decrease in ACh found in the CNS may also occur in the retina (Strenn et ai, 1991), it was considered appropriate by Alhomida et al, (2000) to investigate the effects of tacrine on human retinal AChE activity. In vitro studies on human retinal homogenates showed a concentration-dependent inhibition of AChE activity by tacrine, with an... 

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