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Heterocyclic hydroxylation

The replacement of a heterocyclic hydroxyl group (generally in the 0X0 form, Section II,E, 2,e) with thioxo or chloro groups by phosphorus pentasulfide or phosphorus oxychloride presumably proceeds through nucleophilic substitution (frequently acid-catalyzed, 21 and 86) of thiophosphoryloxy and dichlorophosphoryloxy intermediates. The 4-position in pyrimidine is more reactive than the 2-position and, at low temperature, this type of thionation of pyrimidine-2,4-diones is specific for the 4-position. In as-triazine... [Pg.210]

Related to a class of a,y-diketoacids that has previously been shown to bind to NS5B [64], is the mono-ethyl ester of meconic acid 25. This compound was identified as a selective inhibitor of NS5B HCV polymerase (IC50 = 2.3 pM) and is competitive with the diketoacids. SAR studies have demonstrated the requirement for the carboxylic acid. A variety of different permutations of esters, acids, amides, and decarboxylated compounds were prepared without any improvement in binding affinity or in the cell-based replicon assay [65]. The 4,5-dihydroxypyrimidine-6-carboxylic acids, a hybrid of the a,y-diketoacids and meconic acid, envisioned as chelators of the essential Mg2+ ions in the active site of NS5B, are also active in the polymerase assay (26, IC5o = 5.8pM). While alkylation of the phenol of the hybrid is tolerated, methylation of the heterocyclic hydroxyl groups or the carboxylic acid, as well as decarboxylation, leads to... [Pg.286]

Microsomal oxidations may be subdivided into aromatic hydroxylation aliphatic hydroxylation alicyclic hydroxylation heterocyclic hydroxylation N-, S-, and O-dealkylation N-oxidation N-hydroxylation S-oxidation desulfuration deamination and dehalogenation. [Pg.77]

Heterocyclic hydroxylation. Nitrogen heterocycles such as pyridine and quinoline (Fig. 4.13) undergo microsomal hydroxylation at the 3 position. In quinoline, the aromatic ring is also hydroxylated in positions o and p to the nitrogen atom. [Pg.88]

Heterocyclic hydroxyl derivatives can be divided into two groups according to whether or not the hydroxyl group is exocyclic. Heterocyclic compounds having a hydroxyl substituent in the ring can have hydroxy or oxo tautomeric forms, and in many cases the oxo form is predominant. Nevertheless, regardless of the position of the prototropic equilibria the compounds will be treated under this heading. [Pg.325]

Keywords Alkyl hydroperoxides Amination Ammonia Benzimidazole Benzisoxazole Carbanions Heterocycles Hydroxylation Indole Nitro compounds Nucleophiles Nucleophilic substitution Oxidation Phenazine Potassium permanganate Pyridine Quinoline Sulfones Vicarious... [Pg.51]

Many saturated nitrogen heterocycles are commercially available from industrial processes, which involve, for example, nucleophilic substitution of hydroxyl groum by amino groups under conditions far from laboratory use, e.g. [Pg.149]

Pyranose form (Section 25 7) Six membered ring ansing via cyclic hemiacetal formation between the carbonyl group and a hydroxyl group of a carbohydrate Pyrimidine (Section 28 1) The heterocyclic aromatic com pound... [Pg.1292]

As discussed in Section 4.01.5.2, hydroxyl derivatives of azoles (e.g. 463, 465, 467) are tautomeric with either or both of (i) aromatic carbonyl forms (e.g. 464,468) (as in pyridones), and (ii) alternative non-aromatic carbonyl forms (e.g. 466, 469). In the hydroxy enolic form (e.g. 463, 465, 467) the reactivity of these compounds toward electrophilic reagents is greater than that of the parent heterocycles these are analogs of phenol. [Pg.98]

A surpnsing feature of the reactions of hexafluoroacetone, trifluoropyruvates, and their acyl imines is the C-hydroxyalkylation or C-amidoalkylaOon of activated aromatic hydrocarbons or heterocycles even in the presence of unprotected ammo or hydroxyl functions directly attached to the aromatic core Normally, aromatic amines first react reversibly to give N-alkylated products that rearrange thermally to yield C-alkylated products. With aromatic heterocycles, the reaction usually takes place at the site of the maximum n electron density [55] (equaUon 5). [Pg.843]

Heterocyclic compounds carrying potential hydroxyl groups are cyclic amides or vinylogs of amides. There is much physical evidence that acyclic amides exist almost entirely in the oxo form (for references see reference 6), and the apparent contradiction that ultraviolet spectral data appeared to favor the imidol formulation has now been explained on steric grounds. The value of pKr is estimated to be about 7 on the basis of pK measurements for acyclic amides. Extensive evidence, summarized in the following sections, shows that for a- and y-hydroxy heterocyclic compounds, the cyclic amide form usually predominates by a substantial factor, often ca. 10 . [Pg.342]

Solvent effects also depend on the ground-state structure of the substrate and on the transition-state structure, as is shown below. Here let us merely note that A-heterocyclic compounds tend to form a hydrogen bond with hydroxylic solvents even in the ground state. Hydrogen-bond formation in this case is a change in the direction of quaternization of the aza group, as demonstrated by spectral evidence. Therefore, it is undoubtedly a rate-enhancing interaction. [Pg.308]

Heterocyclic compounds carrying hydroxyl groups may be compared with phenols. Thomson has reviewed the tautomeric behavior of phenols often both tautomeric forms of polycyclic compounds such as naphthols can be isolated. Early work on hydroxy-thiophenes and -furans was also reviewed by Thomsond but until recently their chemistry has been in a somewhat confused state. A pattern is now beginning to emerge, at least for the a-substituted compounds, which appear to exist as A -oxo derivatives and to attain equilibrium slowly with the corresponding A -oxo forms. For the a-hydroxy compounds, the equilibrium generally favors the A -oxo form. [Pg.5]

All the available evidence suggests that five-membered heterocyclic compounds containing a potential hydroxyl group between the two hetero atoms in the 1- and 3-positions exist predominantly in the oxo form (cf. 89 90). [Pg.48]

Free-radical substitutions of heterocyclic compounds have been carried out with alkyl, aryl, and hydroxyl radicals in solution and with halogen atoms in the gas phase. Of these, arylations have been the most extensively investigated. [Pg.131]

Free-radical hydroxylation of heterocyclic compounds has almost always been studied in the context of the relation of chemical hy-... [Pg.163]

The mechanism of hydroxylation of heterocyclic compound has not been studied, but the mechanistic aspects of hydroxylation of homocyclic compounds may again serve as a basis for discussion. [Pg.164]

Heterocyclic compounds have in most cases been hydroxylated by modified forms of Fenton s reagent. For instance, EDTA or pyrophosphate have been added to the system to complex the ferrous ions. It has been shown in the reactions of bcnzenoid compounds, however, that addition of complexing agents does not affect the distribution of isomers obtained by Fenton s reagent,and therefore the hydroxyl radical must still be the hydroxylating species. [Pg.166]

The products obtained in the hydroxylation of heterocyclic compounds are set out in Table XI. [Pg.166]

Udenfriend et al. observed that aromatic compounds are hydroxyl-ated by a system consisting of ferrous ion, EDTA, ascorbic acid, and oxygend Aromatic and heteroaroinatic compounds are hydroxylated at the positions which are normally most reactive in electrophilic substitutions. For example, acetanilide gives rise exclusively to the o-and p-hydroxy isomers whereas quinoline gives the 3-hydroxy prod-uct. - The products of the reaction of this system w ith heterocyclic compounds are shown in Table XIII. [Pg.168]

Hydrazinopyridazines such as hydralazine have a venerable history as anti hypertensive agents. It is of note that this biological activity is maintained in the face of major modifications in the heterocyclic nucleus. The key intermediate keto ester in principle can be obtained by alkylation of the anion of pi peri done 44 with ethyl bromo-acetate. The cyclic acylhydrazone formed on reaction with hydrazine (46) is then oxidized to give the aromatized compound 47. The hydroxyl group is then transformed to chloro by treatment with phosphorus oxychloride (48). Displacement of halogen with hydrazine leads to the formation of endralazine (49). ... [Pg.232]


See other pages where Heterocyclic hydroxylation is mentioned: [Pg.1076]    [Pg.704]    [Pg.158]    [Pg.348]    [Pg.104]    [Pg.1076]    [Pg.704]    [Pg.158]    [Pg.348]    [Pg.104]    [Pg.24]    [Pg.87]    [Pg.20]    [Pg.99]    [Pg.4]    [Pg.517]    [Pg.837]    [Pg.231]    [Pg.565]    [Pg.591]    [Pg.294]    [Pg.335]    [Pg.166]    [Pg.167]    [Pg.64]    [Pg.236]    [Pg.158]   
See also in sourсe #XX -- [ Pg.88 ]

See also in sourсe #XX -- [ Pg.80 ]




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Hydroxylation of heterocycles

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