Meconic acid

This explanation has been revised recently by Bickel, who has shown that the product, C,Hii03N, first formed in this reaction, is the monohydrate of iV-methyl-3-methoxypyridone-4, MeO. CgHjONMe, H2O, the chloride, C,Hio02NCl, is the hydrochloride, MeO. C HgONMe, HCl of the same base, and the substance formed when the chloride is heated is N-methyl-3-hydroxypyridone-4. The constitution of the latter had already been established by Wibaut and Kleipol, who had synthesised it by the action of methylamine on meconic acid (V) and decarboxylation of the resulting product (VI) to the desired substance (VII = IV). 

Mechanisierung,/. mechanization. Mechamsmus, m. mechanism machinery. Meconsaure, /. meconic acid, med., abbrev. (mediziniach) medical, medicinal. Medaille, /. medal. 

Mekonsaure,/. meconic acid. Melangallussaure, /. melanogallic acid, meta. 

Mohn-saft, OT. poppy juice, opium, -samen, ot. poppyseed, -saure,/. meconic acid, -stoff, m. narcotine, -stroh, n. lit., poppy straw (residue from extraction of poppy heads and stems). 

When the name ends in -insdure the translator may substitute -ic acid for this unless another acid already bears the resulting name thus Akridinsdure is often called acridic acid instead of the longer acridinic acid, but Mekonin-sdure should be translated meconinic acid because Mekonsdure has preempted the translation meconic acid. Such exceptions are given in the dictionary as far as possible, but in doubtful cases the longer form -inic acid would be the safer. 

Ricinoleic acid carstor oil. Argot oil Meconic acid Papaveraceaa... 

Related to a class of a,y-diketoacids that has previously been shown to bind to NS5B [64], is the mono-ethyl ester of meconic acid 25. This compound was identified as a selective inhibitor of NS5B HCV polymerase (IC50 = 2.3 pM) and is competitive with the diketoacids. SAR studies have demonstrated the requirement for the carboxylic acid. A variety of different permutations of esters, acids, amides, and decarboxylated compounds were prepared without any improvement in binding affinity or in the cell-based replicon assay [65]. The 4,5-dihydroxypyrimidine-6-carboxylic acids, a hybrid of the a,y-diketoacids and meconic acid, envisioned as chelators of the essential Mg2+ ions in the active site of NS5B, are also active in the polymerase assay (26, IC5o = 5.8pM). While alkylation of the phenol of the hybrid is tolerated, methylation of the heterocyclic hydroxyl groups or the carboxylic acid, as well as decarboxylation, leads to... 

Comenic acid (10) - not to be confused with comanic acid, a 2-pyranone carboxylic acid - can be obtained by decarboxylation (by boiling in 50% hydrochloric acid (19)) of meconic acid (8), or from kojic... 

N.A. Morphine, narcotine, codeine, papaverine, meconic acid, albumin, mucilage, sugars, resin, wax.99 Sedate or suppress nervous system activity, pain, and coughs. 

Mallol Malonic acid Malvin Mannitol Margaric acid Massoilactone Mastic acid Masticin Matatabic acid Matatabiether Matatabistic acid Maysin Meconic acid... 

Meconic acid (3-hydroxy-Y-pyrone-2,6-dicarboxylic acid) [497-59-6] M 200.1, m 100 (-H2O). Crystd from water and dried at 100° for 20min. 

Meconic acid is beet obtained in a state of purity by dissolving the pure meconate of potassa in eighteen parts of hot water, and adding two or three parts of concentrated hydrochloric acid. As the liquid cools crystals are deposited, which are rodissolved in water, again treated with hydrochloric add, and thus obtained entirely free from potassa. It should not be boiled in presence of any acid, as it is thus converted into koraenio acid. 

Meconic acid forms beautiful pearly crystalline scales, of a harsh sour taste, sparingly soluble in cold, but more readily In hot water and in alcohol. The anhydrous acid consists of Clt nOa, and is denoted by the. symbol Me the acid dried at 212° contains in addi-... 

When meconic acid (490) is partly esterified and heated, it loses carbon dioxide and forms comenic acid (491) which is itself decarboxylated (as is meconic acid) to pyromeconic... 

Opium.—If opium is subjected to the action of the electric current, morphine (Ci7Hi9NO(OH)2) goes to the cathode and meconic acid (oxypyronedicarboxylic acid) to the anode (Lassaigne).3... 

Sertiirner s claims to have already obtained morphine in 1806 seem largely unsubstantiated, since he probably isolated what became later known as meconic acid and he unequivocally reported the isolation of a narcotic opium basic compound only in 1817. For a discussion, see F. A. Chast, in The Practice of Medicinal Chemistry, ed. C. G. Wermuth, Elsevier, Amsterdam, 3rd edn, 2008, pp. 3-62. 

Opium contains many peculiar chemical principles, but its narcotic properties are chiefly owing to one of these, the alkaloid Morphia. Of this, good opium contains about twelve percent, in combination with Meconic acid. Tliis morphia may be extracted from opium, and used separately, either in the pure form or in combination with various acids, with which it forms salts soluble in water and spirit. Morphia resembles opium in its action, but is rather less stimulating. It may be used in the same cases. 

Crude opium. Opium crudum, Pharm. Eur. has a morphine content of 12-16% whereas the pharmacopoeias require 10%. The alkaloids are bound to meconic acid, lactic acid, fumaric acid and sulphuric acid. Opium has a very characteristic smell and can be identified microscopically by the occurrence of characteristic fragments from the wall of the capsule. 

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