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HER2 expression

At Leica Biosystems Newcastle Ltd., invasive breast cancer tissue controls, demonstrating HER2 expression levels at 3+, 2+, 1+, and 0, are incorporated into all Oracle HER2 Bond IHC System cell line quality control runs. This ensures that control cell lines are validated as a viable assay control. The evaluation of control cell lines should always be performed within the context of appropriate tolerance limits. Subtle changes from batch to batch may occur, and it is the correct evaluation of the cell line staining patterns within appropriate tolerance limits that enables control cell lines to be utilized both in a commercial setting and as an EQA monitoring device. [Pg.111]

Commercially processed HER2 expressing cell lines offer opportunities for enhanced standardization to both laboratories and companies participating in... [Pg.111]

Liang, C. H., Shiu, L. Y, Chang, L. C., Sheu, H. M., Tsai, E. M., Kuo, K. W. (2008). Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer H661 and H69 cells to trastuzumab and epirubicin. Chem. Res. Toxicol., 21, 393-399. [Pg.421]

BOX 14.1. HOW HERCEPTIN NAS APPROVED AS A THERAPY THAT REQUIRES HER2 EXPRESSION TESTS ON PATIENT TUMOR TISSUES BEFORE USE... [Pg.397]

Patient tissues were evaluated using an immunohistochemical staining for HER2 proteins based on a 0-3 scale where 0 = none detected and 3 being strongly positive. Patient tissues with 2 scores are considered weakly positive for HER2 expression. [Pg.398]

Cox, G., Vyberg, M., Melgaard, B., Askaa, J., Oster, A., and O Byrne, K. J. 2001. Herceptest HER2 expression and gene amplification in non-small cell lung cancer. Int. J. Cancer. 92 480-483. [Pg.312]

Gu, X. G., Schmitt, M., Hiasa, A., Nagata, Y., Ikeda, H., Sasaki, Y., Akiyoshi, K., Sunamoto, J., Nakamura, H., Kuribayashi, K., and Shiku, H. (1998), A novel hydropho-bized polysaccharide/oncoprotein complex vaccine induces in vitro and in vivo cellular and humoral immune responses against HER2-expressing murine sarcomas, Cancer Res., 58(15), 3385-3390. [Pg.557]

Asada S, Choi Y, Yamada M, et al. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc Natl Acad Sci USA 2002 99 12747-12752. [Pg.314]

Metastasized human epidermal growth factor receptor 2 (HER2)-expressing breast cancer treatment was the first indication for trastuzumab, a HER2-specific humanized monoclonal antibody. HER2 is a receptor tyrosine kinase of the EGER family that is overexpressed... [Pg.140]

Figure 11.9 Monitoring the effect of 17-AAG on tumor HER2 expression, (a) MicroPET determination of average HER2 expression in two groups of mice (n = 5) over a 1-week period. One group of mice were treated with 3 x 50 mg/kg 17-AAG after the initial micro-PET scan the control group was treated with vehicle only. The data normalized to the initial pretreatment uptake value, (h) Western hlot analysis of HER2 and the 85 kDa regulatory subunit of P13 kinase expression in BT-474 tumors from control mice and ftom mice 24 h after treatment with 17-AAG. [Figure adapted from Smith-Jones et al. (25)]... Figure 11.9 Monitoring the effect of 17-AAG on tumor HER2 expression, (a) MicroPET determination of average HER2 expression in two groups of mice (n = 5) over a 1-week period. One group of mice were treated with 3 x 50 mg/kg 17-AAG after the initial micro-PET scan the control group was treated with vehicle only. The data normalized to the initial pretreatment uptake value, (h) Western hlot analysis of HER2 and the 85 kDa regulatory subunit of P13 kinase expression in BT-474 tumors from control mice and ftom mice 24 h after treatment with 17-AAG. [Figure adapted from Smith-Jones et al. (25)]...
PCT) probes for HER2 expression in breast cancer. Bioconjugate Chem. 2008,19,1186-1193. [Pg.43]

Immunization with the CHP-HER2 complex is therapeutically effective against HER2 expressing tumors... [Pg.333]

We questioned whether CD8 T cells were also the effector cells in vivo for the prevention of HER2 expressing tumor cells. After the second immunization with CHM-HER2, the mice were administered monoclonal antibodies against CD4, CD8, or their combination one day before the tumor challenge. The suppression of the tumor growth was abohshed by the... [Pg.333]

In our present study, the HER2 protein required hydrophobized polysaccharides for the induction of a CTL response and the rejection of HER2 expressing tumor cells in vivo. These CTLs were K restricted CD8 T lymphocytes specifically recognizing the HER2 derived peptide p63-71, a part of the HER2 protein used for the vaccine, indicating that a soluble oncoprotein could enter the class 1 pathway by the help of CHM or CHP. [Pg.336]

Having established that bone marrow-derived DCs can efficiently stimulate both CD4 T eells and CD8" T cells, we examined their usefulness for immimotherapy of HER2 expressing tumors. In fact treatment of mice... [Pg.336]


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See also in sourсe #XX -- [ Pg.397 ]




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HER2/neu expression

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