Hepatotoxicity anabolic steroids

The anabolic steroids can cause serious adverse reactions including tumorigenesis, testicular atrophy with decreased spermatogenesis and in women virilization. Anabolic steroid abuse in sports where excessive doses are used, is associated with among others hepatotoxicity. 

Reversible hepatotoxicity, in the form of abnormal liver function tests, led to the withdrawal of stanozolol in a patient with lipodermatosclerosis (54). Since some dermatologists continue to have faith in anabolic steroids in this condition, the patient was then given oxan-drolone, which is reputed to be less hepatotoxic. The hepatic problems did not recur, although several months later the patient developed a cardiomyopathy, which may have been coincidental. 

Echinacea 1. Hepatotoxic drugs, e.g. anabolic steroids 2. amiodarone 3. Methotrexate 4. Ketoconazole Risk of additive hepatotoxicity Use of echinacea for over 8 weeks can cause hepatotoxicity Be aware and use drugs with a potential to cause hypertonicity cautiously, monitoring clinically and biochemically for any early signs of hepatic dysfunction... 

Although the horse appears to be refractory to the hepatic effects of most NSAIDs, their hepato-toxic potential should be considered, especially when they are concomitantly administered with other potentially hepatotoxic agents, such as fluoroquinolones, potentiated sulfonamides or anabolic steroids. In addition, many herbal preparations are potential hepatotoxic agents and clients may administer these compounds concurrently with prescribed NSAIDs without consulting their veterinarian. Echinacea and kava kava products, for example, are reported to be potential hepatotoxins and both are used in herbal remedy products that claim to produce calming or sedating effects in horses (Abebe 2002). 

Dickerman R, Pertusi R, Zachariah N, Dufour D, McConathy W. Anabolic steroid-induced hepatotoxic-ity Is it overstated Clin J Sport Med 1999 9 34-9. 

I7(x-Methyl-17 -hydroxy-estra-4,9,l l-trien-3-one (Methyltrienolone, N-99). In the course of a steroid total synthesis [293] this compound (Methyltrienolone, N-99) was prepared it was reported [55] to possess 6000% of the androgenic (ventral prostate index), 7500% of the androgenic (seminal vesicles index), and 12,000% of the anabolic (levator ani index) activity of methyltestosterone. Later the anabolic activity was reported [74] to be 30,000% of that of methyltestosterone. As measured by multiple parameters methyltrienolone turned out to be the most hepatotoxic steroid, causing biochemical symptoms of intrahepatic cholestasis [75]. It was also reported [74] to reduce the excretion of 17-ketosteroids and 17-hydroxycorticosteroids and to cause enhancement of the blood coagulation factors V, VII, and X. It also increases the prothrombin content of the plasma [74]. 

Yet another classification system refers to the nature of the host s response to the causative agent. Some agents, referred to as intrinsic hepatotoxicants, will cause hepatotoxicity in most individuals of most species. In the case of idiosyncratic hepatotoxicants, where a chemical s toxic effects are a function of unusual susceptibility of the exposed individual, it may not be clear whether the lesion is a manifestation of the hepatotoxic properties of the substance in question or a manifestation of the individual s untoward response to the agent. This response may mean hypersensitivity (allergic) reactions or exaggerated responses to minor alterations in liver function. For example, anabolic or contraceptive steroids cause diminished biliary excretion (cholestasis) in most... 

Ishak, K.G. and Zimmerman, H.J. (1987) Hepatotoxic effects of the anabolic/ androgenic steroids. Seminars in Liver Disease, 7, 230-236. 

---