Heparin-binding epidermal growth factor

Jin, K., Sun, Y., Xie, L., Childs, J., , X.O., Greenberg, D.A. (2004). Post-ischemic administration of heparin-binding epidermal growth factor-like growth factor (HB-EGF) reduces infarct size and modifies neurogenesis after focal cerebral ischemia in the rat. J... 

Jin, K., Mao, X. O., Del Rio Guerra, G., Jin, L., and Greenberg, D. A. (2005). Heparin-binding epidermal growth factor-like growth factor stimulates cell proliferation in cerebral cortical cultures through phosphatidylinositol S kinase and mitogen-activated protein kinase. J. Neurosci. Res. 81, 497-505. 

Yang X, Zhu MJ, Sreejayan N, Ren J, Du M. 2005. Angiotensin II promotes smooth muscle cell proliferation and migration through release of heparin-binding epidermal growth factor and activation of EGF-receptor pathway. Mol Cells 20 263-270. 

Piepkorn, M., Pittelkow, M.R., and Cook, P.W., Autocrine regulation of keratinocytes the emerging role of heparin-binding, epidermal growth factor-related growth factors, / Invest. Dermatol., 111, 715, 1998. 

Morita, T., Yoshizumi, M., Kurihara, H., Maemura, K., Nagai, R., and Yazaki, Y. (1993b). Shear stress increases heparin-binding epidermal growth factor-like growth factor mRNA levels in human vascular endothelial cells. Biochem. Biophys. Res. Commun. 197, 256-262. 

Mehta VB, Besner GE. Heparin-binding epidermal growth factor-like growth factor inhibits cytokine-induced NF-kappa B activation and nitric oxide production via activation of the phosphatidylinositol 3-kinase pathway. J Immunol 2005 175(3) 1911-1918. 

Many studies have established the mechanism underlying the initial adhesion of mouse embryo to the uterus. Thus, ErbB4 (one of ErbB family receptor tyrosine kinases) expressed on the blastocyst surface binds to the membrane-bound form heparin-binding epidermal growth factor (HB-EGF) expressed by uterine epithelia (33-35). These studies indicated that the implanting blastocyst induces HB-EGF in the maternal epithelia in a spatially and temporally dependent manner, demonstrating interaction between maternal cells and implanting embryo prior to the adhesion (35). 

K., Kawata, S., Taniguchi, N., and Matsuzawa, Y. (1997) Role of Membrane-Anchored Heparin-Binding Epidermal Growth Factor-Like Growth Factor and CD9 on Macrophages, Biochem. J. 328,923-928. 

Chobotova K, Spyropoulou I, Carver J, Manek S, Heath JK, Gullick WJ, Barlow DH, Sargent IL, Mardon HJ. 2002. Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst. Mech Dev 119(2) 137-144. 

Miyamoto S, Yagi H, Yotsumoto F, Kawarabayashi T, Mekada E. 2006. Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy. Cancer Sci 97(5) 341-347. 

Heparin-binding epidermal growth factor-like growth factor mRNA expression and protein were seven-fold increased in human bronchial epithelial cell cultures exposed to V2O5 (Zhang et al. 2001)... 

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