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ErbB receptors

ErbB Receptor Family Erectile Dysfunction ERGIC... [Pg.1491]

Avian erythroblastosis virus erbB Receptor for growth factor tyrosine kinase activity... [Pg.245]

ErbB (or HER in the human). There are four ErbB receptors that form homo- or heterodimers in various combinations upon ligand binding. Specific NRG isoforms preferentially interact with different ErbB dimers. The ErbB receptors are ligand-activated tyrosine kinases structurally similar to the EGF receptor. [Pg.482]

Buonanno, A. and Fischbach, G. D. Neuregulin and ErbB receptor signaling pathways in the nervous system. Curr. Opin. Neurobiol. 11 287-296,2001. [Pg.484]

In addition to the approaches covered in a recent review [20], the first comprehensive model covering receptor dimerization and internalization has been recently described [21], In this work, the authors use direct time-dependent measurement of the phosphorylation of the four ErbB receptor species, as well as protein quantitation to develop a comprehensive mechanistic model of receptor dimerization and internalization. Once this comprehensive, quantitative framework was developed, the authors were able to show that receptor dephosphorylation, a key step in the downregulation of ErbB-driven signaling, was restricted to intracellular compartments. [Pg.398]

Baulida, J., M. H. Kraus, M. Alimandi, P, P. Di Fiore, and G. Carpenter. All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J Biol Chem. 271 5251-5257.1996. [Pg.126]

Waterman, H., I. Sabanai, B. Geiger, and Y. Yarden. Alternative intracellular routing of ErbB receptors may determine signaling potency. J Biol Chem. 273 13819-13827.1998. [Pg.138]

Waterman, H., and Y. Yarden. Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases. FEBS Lett. 490 142-52.2001. [Pg.138]

ErbB receptors exhibit conserved structural similarity and domain topography (Fig. 1). They contain an extracellular ligand-binding region, which consists of two cysteine-rich domains, and is responsible for ligand-induced receptor dimerization. This... [Pg.105]

Hynes NE, Lane HA. ERBB receptors and cancer the complexity of targeted inhibitors. Nat Rev Cancer 2005 5 341-354. [Pg.121]

Singh J, Dobrusin EM, Fry DW et al. Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases. J Med Chem 1997 40 1130-1135. [Pg.125]

Normanno N, Bianco C, Strizzi L, Mancino M, Maiello MR, De Luca A, Caponigro F, Salomon DS. 2005. The ErbB receptors and their ligands in cancer an overview. Curr Drug Targets 6 243-257. [Pg.226]

Riese DJ II, van Raaij TM, Plowman GD, Andrews GC, Stern DF. 1995. The cellular response to neuregulins is governed by complex interactions of the erbB receptor family. Mol Cell Biol 15 5770-5776. [Pg.264]

Rio C, Rieff HI, Qi P, Khurana TS, Corfas G. 1997. Neuregulin and erbB receptors play a critical role in neuronal migration. Neuron 19 39-50. [Pg.264]

Russell KS, Stern DF, Polverini PJ, Bender JR. 1999. Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis. Am J Physiol 277 H2205-H2211. [Pg.264]

III. Associadon of ErbB Receptors with Human Disease. 6... [Pg.1]

Fig. 1. Domain architecture of ErbB receptors. ErbB receptor extracellular regions are composed of four subdomains arranged as a tandem repeat of two types of domains. Two domain nomenclatures have been proposed (Bajaj et al., 1987 Lax et al., 1988 Ward et al., 1995). The domains in order from the N-terminus are referred to as domain I (El), II (CRl), III (L2), and IV (CR2). Domains I and III are homologous domains III and IV are homologous. The extracellular region is followed by a single membrane-spanning region, a cytoplasmic tyrosine kinase, and variable length tail that harbors several phosphorylation sites. Fig. 1. Domain architecture of ErbB receptors. ErbB receptor extracellular regions are composed of four subdomains arranged as a tandem repeat of two types of domains. Two domain nomenclatures have been proposed (Bajaj et al., 1987 Lax et al., 1988 Ward et al., 1995). The domains in order from the N-terminus are referred to as domain I (El), II (CRl), III (L2), and IV (CR2). Domains I and III are homologous domains III and IV are homologous. The extracellular region is followed by a single membrane-spanning region, a cytoplasmic tyrosine kinase, and variable length tail that harbors several phosphorylation sites.

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See also in sourсe #XX -- [ Pg.246 , Pg.248 , Pg.250 , Pg.251 , Pg.253 , Pg.254 , Pg.257 ]




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Aspects of ErbB Receptors

Epidermal Growth Factor Receptor 2 (ErbB

ErbB Receptor Family

ErbB receptors activating

ErbB receptors breast cancer association

ErbB receptors characterization

ErbB receptors direct

ErbB receptors intracellular

ErbB receptors ligands

ErbB receptors signaling network

Structure of Entire ErbB Receptor Ectodomains

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