Hederagenine

Lee MW, Kim SU, Hahn DR. Antifungal activity of modified hederagenin glycosides from the leaves of Kalopanax pictum var. chinense. Biol Pharm Bull 2001 24 718-719. 

Takagi K, Park EH, Kato H. Anti-inflammatory activities of hederagenin and crude saponin isolated from Sapindus mukorossi Gaertn. Chem Pharm Bull (Tokyo) 1980 28 1183-1188. 

Aristolochia contorta Bunge. A. kaempferi Willd. A. longa Thunb. A. recurvilabra Hance Ma Dou Ling (stem) Aristolochic acid A, aristolochic acid D, aristoloside, magnoflorine, oleanolic acid, beta-sitosterol, hederagenin.48 This herb is toxic. Treat pulmonary disorders, antitussive, an expectorant in asthma and bronchitis. 

Hederagenin Aristolochia contorta, A. kaempferi, A. longa, A. recurvilabra, Caulophyllum robustum... 

Electrochemical bromo-lactonization of the triterpenoid oleanolic acid 80 has been performed in an MeOH—E NBr/fPhSe —(Pt) system to give 12a/p/in-bromo-28,13-he/a-oleanolide 81 in quantitative yield. On the other hand, constant current electrolysis of 80a or hederagenin 80b in an MeOH/AcOEt—Et4NBr—(C) system forms 82 in 90-92 % yields (Schetne 3-30) 78a>. 

A mixture of Bu3SnH (200 mg, 0.69 mmol) in p-cymene (3 ml) was added dropwise to a solution of methyl xanthate of hederagenin (50 mg, 0.087 mmol) at 150 °C. After 10 h, CC14 was added to the mixture and the mixture was refluxed for 3 h. After the reaction, the solvent was removed. A solution of iodine in ether was added to the mixture. The organic layer was washed with 10% KF aq. solution (5 ml), dried over Na2S04, and filtered. After removal of the solvent, methyl oleanoate was obtained by recrystallization [38]. 

Eq. 7.2 shows a typical deoxygenative reaction of hederagenin (3) via methyl xanthate (4) with Bu3SnH in the presence of AIBN under benzene refluxing conditions. 

Hederagenin Hedera helix (Araliaceae), LELA [62 pM], pancreatic [108,... 

Hederagenin Hedera helix, Kalopanax pictus HypoGlc, hypochoiestero-... 

The crystal structures of the triclinic and orthorhombic forms of 18aH-oleanane (147), from Nigerian crude petroleum, have been reported. Other crystal structures include meristropic acid methyl ester (148), hederagenin (149) from... 

Preliminary structure-activity relationship studies on triterpene saponins have shown the best activity against HSV-1, -2, adenovirus (AD-2), polyovirus (PV-2) and VSV for saponins having as aglycones ursolic acid, glycyrrhetinic acid, hederagenin and oleanolic acid [152],... 

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