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18/3-glycyrrhetinic acid

The naturally occurring anti-inflammatory agent in egg-yolk was later identified as iV-(2-hydroxyethyl)palmitamide , and shown to be identical with a crystalline fraction prepared from arachis oil and soya bean lecithin which is active at 0-3 g/kg in the guinea-pig anaphylactic arthritis test . It is not active, however, in a cotton-pellet test or in a capillary permeability test in rats. When the compound is degraded, anti-allergic activity resides in [Pg.108]

The salts of 3-acetyl-18/3-glycyrrhetinic acid can be prepared by reaction between 3-acetyl-18/3-glycyrrhetinic acid and an aluminum alcohoiate. Preferably lower alcoholates are used, i.e., alcoholates in which the alkoxy group or groups have from one to four carbon atoms. The salification reaction may be carried out at room temperature or at an elevated temperature in conventional fashion, preferably in the presence of organic solvents. As organic solvents may be used alcohols, ethers, ketones, chlorinated solvents (methylene chloride, chloroform) ethyl acetate, etc. [Pg.19]

Chemical Name 3/3-hydroxy-11-oxo-20/3-olean-l2-en-29-oic acid hydrogen butanedioate Common Name Glycyrrhetinic acid hydrogen succinate Structural Formula ... [Pg.238]

One molecular proportion of glycyrrhetinic acid hydrogen succinate was ground with a dilute (5%) aqueous solution containing two molecular proportions of sodium hydroxide. [Pg.239]

The solution was filtered and evaporated in vacuum over concentrated sulfuric acid. The sodium salt is then obtained as a creamy white water-soluble solid. Glycyrrhetinic acid is obtainable from licorice root. [Pg.239]

Figure 5.1 Structures of the pure triterpenes studied by GALDI MS hydroxydammarenone (20 hydroxydammar 24 en 3 one) 1, oleanolic acid (3 hydroxyolean 12 en 28 oic acid) 2, oleanonic acid (3 oxoolean 12 en 28 oic acid) 3, 18(3 glycyrrhetinic acid ((3(3,18(3,20(3) 3 hydroxy 11 oxoolean 12 en 29 oic acid) 4, uvaol (urs 12 en 3,28 diol) 5, ursolic acid (3 hydroxyurs 12 en 28 oic acid) 6, and ursonic acid (3 oxours 12 en 28 oic acid) 7... Figure 5.1 Structures of the pure triterpenes studied by GALDI MS hydroxydammarenone (20 hydroxydammar 24 en 3 one) 1, oleanolic acid (3 hydroxyolean 12 en 28 oic acid) 2, oleanonic acid (3 oxoolean 12 en 28 oic acid) 3, 18(3 glycyrrhetinic acid ((3(3,18(3,20(3) 3 hydroxy 11 oxoolean 12 en 29 oic acid) 4, uvaol (urs 12 en 3,28 diol) 5, ursolic acid (3 hydroxyurs 12 en 28 oic acid) 6, and ursonic acid (3 oxours 12 en 28 oic acid) 7...
Carbenoxolone (B) is a derivative of glycyrrhetinic acid, which occurs in the sap of licorice root (succus Uquiri-tiae). Carbenoxolone stimulates mucus production. At the same time, it has a mineralocorticoid-like action (due to inhibition of 11-p-hydroxysteroid dehydrogenase) that promotes renal reabsorption of NaCl and water. It may, therefore, exacerbate hypertensioa congestive heart failure, or edemas. It is obsolete. [Pg.168]

Killacky, J., M. S. F. Ross, and T. D. Turner. 1976. The determination of beta-glycyrrhetinic acid in liquorice by high pressure liquid chromatography. Plant Med. 30 310-316. [Pg.328]

Mishima, M., et al. 1995. Promotion of rectal absorption of sodium ampicillin by disodium glycyrrhetinic acid 3(3-0-monohcmiphthalatc in rats. Biol Pharm Bull 18 566. [Pg.171]

Glycoluril derivatives, inclusion chemistry, 12, 814 18/3-Glycyrrhetinic acid, with trinuclear Ru and Os clusters, 6, 743... [Pg.110]

Hydrocortisone Glycyrrhetinic add potentiates of Glycyrrhetinic acid is a more potent inhibitor of... [Pg.40]

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18-P-Glycyrrhetinic acid

18-P-Glycyrrhetinic acid (glycyrrhetic

18-P-Glycyrrhetinic acid (glycyrrhetic effects on LELA

18a-Glycyrrhetinic acid

3-Acetyl-18 3-glycyrrhetinic acid

Beta-glycyrrhetinic acid

Glycyrrhetin

Glycyrrhetinic acid (Glycyrrhetic

Glycyrrhetinic acid allylic oxidation

Glycyrrhetinic acid from liquorice

Glycyrrhetinic acid glycoside

Glycyrrhetinic acid hydrogen succinate

Glycyrrhetinic acid, absorption

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