Metal , heavy, antidotes

THERAP CAT (VET) Astringent, hemostatic, in solutions for burns. Has been used internally as an astringent and as a heavy metal antidote. 

Therapeutic Function Heavy metal antidote Chemical Name 2,3-dimercapto-1-propanol Common Name 1,2-dithioglycerol... 

Belhnger, D.C., K.M. Stiles and H.L. Needleman. (1992) Low-level lead exposure, intelligence and academic achievement A long-term follow-up study. Pediatrics 90 855-861 Bernal, J., J.H. Lee, L.L. Ciibbs and E. Perez-Reyes. (1997) Full reversal of Pb + block of L-type Ca channels requires treatment with heavy metal antidotes. J. Pharmacol. Exp. Then 282 172-180... 

Elicitatian of an autoimmune response. This mechanism is not well-sludied in veterinary medicine. D-Penicillamine, sometimes used as a heavy metal antidote in animals, has been associated with an inflaniniatory myopaliiy that is considered to be the resuh of an autoimmune mechanism. 

Therapeutic Function Antidote in heavy metal poisoning Chemical Name N-(2-Mercapto-1-oxopropyl)glycine Common Name Mercamidum... 

Use antidote (heavy metal poisonings), antirheumatic (PCA and Morbus Wilson)... 

Benfey, Otto Th. Spinach as an alchemical antidote to heavy metal poisoning. Kagakushi J Japanese Soc Hist Chem 15 (1981) 8-12. 

Chelating agents are widely used as specific antidotes for heavy metals. They form stable, soluble, nontoxic complexes and in easily excreted form. They promote dissociation of bound metal from tissue enzymes and other functional macromolecules. These metal chelates are water soluble, e.g. EDTA, BAL, desferrioxamine etc. 

I heavy metal ions with electrostatic interactions yO- and are used as antidotes in heavy metal poisoning (and I though all I had to do was Q turn off the radio ). 

Tolerance to heavy metals, specifically mercury and cadmium, has been associated with the induction of kidney metallothionein, a protein rich in sulfhydryl groups which protects by chelation (102). The synthetic antidote dimercaprol, introduced after World War I for arsenic-containing gases, works by a similar mechanism (103). 

The first chelating agent developed as an antidote to a heavy metal poison was 2,3-dimereaptopropanol (dimercaprol, British Anti-Lewisite, BAL). Originally intended for use on victims of the arsenical vesicant poison gas Lewisite52, it has since proved efficacious in the treatment of antimony, gold and mercury poisoning as well as... 

Detoxication of Metals. Pectins or pectin derivatives have been proposed as antidotes for heavy metal poisoning for nearly 200 years. Kertesz (9) has reviewed the early work in this area. Pectin complexes lead so strongly as to quantitatively remove it from solution. Absorption 6f lead, arsenic, and selenium by several animal species has been reduced by pectin- or apple-containing diets. Use of pectin as a prophylactic agent in lead poisoning continues to be of interest. Bondarev (88) recently reported an increase in excretion and a decrease in bone accumulation of lead when rats fed 6 mg/day of lead also received 72-432 mg/day of low ester pectin. Paskins-Hurlburt et al. (89) achieved an 87% decrease in lead absorption by pectate fed rats. These studies bear out the early observations of Fellenburg (see 9, p. 572), who concluded that pectin of decreased ester content would have an enhanced ability to complex metals. 

Why is milk or raw egg used as an antidote in cases of heavy metal ion poisoning ... 

Some antidotal substances used in the treatment of plant or heavy metal toxicity in animals could be... 

The antidotal properties of BAL arc a.ssociatcd with the property of heavy metals to react with sullliydryl (SH) groups in proteins (e.g., tlie en/.yme pyruvate oxidase) and interfere with their normal function. 1.2-Dilhiol compounds such as BAL compete effectively with such proteins for the metal by reversibly forming metal ring compounds of the following type ... 

British antilewisite (BAL) or dimercaprol was developed as an antidote for lewisite. It is used in medicine as a chelating agent for heavy metals. Although BAL can cause toxicity itself, evidence suggests that BAL in oil administered intramuscularly will reduce the systemic effects of lewisite. BAL skin and ophthalmic ointment decrease the severity of skin and eye lesions when applied immediately after early decontamination, but neither of these ointments is currently manufactured. 

Ro 1-7977 Chemet ) is a CHELATING AGENT, used as an ANTIDOTE for heavy metal poisoning (Pb. As, Hg) and as a diagnostic agent. A Tc derivative is used in renal scintigraphy. 

Use Medicine (antidote in heavy-metal poisoning), in foods to complex trace heavy metals, as a preservative, and to retain color and flavor antigushing agent in fermented malt beverages. (For restrictions on food uses, see FDA regulations.)... 

Use Antidote to Lewisite, organic arsenicals, and heavy metals. 

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