Diagnostic agent

Kinetics of the biodistribution must be compatible with the practical aspects of hospital routine and imaging capabiUty. In the case of a diagnostic agent, maximal lesion contrast, maximal radioactivity concentrations in tissue of interest, and minimal background radioactivity during the time imaging... 

Diagnostic Radioisotopes. In order to be useful as an m vivo diagnostic agent, a radioisotope needs to possess a number of characteristics. 

The role of the platelet integrin GPIIb/IIIa receptor and its potential utility as a radio-diagnostic agent in the rapid detection of thromboembolic events has been demonstrated [6]. This approach may be useful for the noninvasive diagnosis of various thromboembolic disorders. 

The chemistry of technetium toward improved diagnostic agents. M. J. Clarke and P. H. Fackler, Struct. Bonding (Berlin), 1982, 50, 58-78 (178). 

Clarke MJ, Fackler PH (1982) The Chemistry of Technetium Toward Improved Diagnostic Agents. 50 57-58... 

Osawa M, Satoh F, Horiuchi H, Tian W, Kugota N, Hasegawa I Postmortem diagnosis of fatal anaphylaxis during intravenous administration of therapeutic and diagnostic agents evaluation of clinical laboratory parameters and immunohistochemistry 25 in three cases. Leg Med (Tokyo) 2008 10 143-147. 

Intradermal 0.05 1/2-5/8 in., 25-26 gauge Should be isotonic Diagnostic agents... 

Diagnostic drugs, such as sodium fluorescein, are administered topically or intravenously to aid in the diagnosis of such conditions as corneal abrasions or ulceration and various retinopathies. This agent has become the most widely used diagnostic agent in the... 

Despite the evidence for the cytotoxicity of CNTs, there are an increasing number of published studies that support the potential development of CNT-based biomaterials for tissue regeneration (e.g., neuronal substrates [143] and orthopedic materials [154—156]), cancer treatment [157], and drug/vaccine delivery systems [158, 159]. Most of these applications will involve the implantation and/or administration of such materials into patients as for any therapeutic or diagnostic agent used, the toxic potential of the CNTs must be evaluated in relation to their potential benefits [160]. For this reason, detailed investigations of the interactions between CNTs/CNT-based implants and various cell types have been carried out [154, 155, 161]. A comprehensive description of such results, however, is beyond the scope of this chapter. Extensive reviews on the biocompatibility of implantable CNT composite materials [21, 143, 162] and of CNT drug-delivery systems [162] are available. 

The first proteins from transgenic plants to reach commercial status were avidin and P-glucuronidase (GUS) both of which are used as diagnostic agents in molecular biology. An important principle demonstrated by these case studies is that molecular farming in cereals can be an economical alternative even when the natural source of a protein is abundant (i.e. egg whites for avidin, and Escherichia coli for GUS) and where a market is already established. 

S.Y. Ho and E.R.T. Tiekink, in Metallotherapeutic Drugs and Metal-based Diagnostic Agents, M. Gielen and E.R.T. Tiekink (eds), John Wiley Sons, Chichester, 2005, 507. 

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