Health issues reproductive toxicity

First, reproductive and developmental lead toxicity in both men and women remains a significant human health issue on several grounds, whether adequately characterized in terms of dose—response relationships or not. Occupational lead exposures remain as sources of toxicity in both industrialized and developing countries. These exposures of both male and female workers potentially persist at levels not greatly different from those reported in past decades. 

No animal or human data were available for inhalation exposure. There are no data regarding effects in humans after oral exposure. Information is available in animals regarding health effects following acute, intermediate, and chronic oral ingestion of diisopropyl methylphosphonate. The animal data obtained after oral exposure indicate that diisopropyl methylphosphonate is moderately toxic after acute bolus exposure but has a lower order of toxicity after intermediate and chronic exposures in food. No data were found on the toxicity of diisopropyl methylphosphonate after exposure in drinking water. Further, diisopropyl methylphosphonate is rapidly metabolized and excreted and does not accumulate. It does not appear to have reproductive or developmental effects. At the doses tested, it does not appear to be an acetylcholinesterase inhibitor, although this issue has not been resolved yet. Limited data are available for dermal exposure in humans and animals. Diisopropyl methylphosphonate does not appear to be a... 

Develop SOPs relevant to safety and health considerations to be followed when laboratory work involves the use of hazardous chemicals. This is especially the case if your lab operations include the routine use of select carcinogens, reproductive toxins, and substances of acute toxicity. SOPs can function as stand-alone documents or supplemental information included as part of research notebooks, experiment documentation, or research proposals. The key idea with laboratories having SOPs is to ensure a process is in place so that an experiment is well thought out and includes and addresses relevant health and safety issues. 

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