Hamster, cholesterol

BALMIR F, STAACK R, JEFFREY E, JIMENEZ M D, WANG L and POTTER S M (1996) An extract of SOy flour influences serum cholesterol and thyroid hormones in hamsters. J Nutr. 126 (12) 3046-53. 

POTTER s M, FERTILE J and BERBER-JIMENEZ M D (1996) Soy protein concentrate and isolated soy protein similarly lower blood serum cholesterol hut differently affect thyroid hormones in hamsters. J Nutr. 126 (8) 2007-11. 

RONG N, AUSMAN L M, NICOLOSI R J (1997) Gamma-oryzanol decreases cholesterol absorption and aortic streaks in hamsters. Lipids 32(3) 303-9. 

Hara, S., et al. S-8921, an ileal Na+/ bile acid cotransporter inhibitor decreases serum cholesterol in hamsters. Life Sci. 1997, 60, 365-370. 

In addition to fluorescence methods, another study [27] developed a method to permit electron microscopic localization of Ras anchor domains on cytoplasmic membrane surfaces by immunogold labeling. The particle neighbor distances can be analyzed to obtain information about possible domain structure. Expressing H-Ras and K-Ras in baby hamster kidney cells, a nonrandom particle distribution was obtained from which the estimated mean raft size was 7.5-22 nm and about 35% of the membrane area consists of rafts. The same technique applied to cells that had been incubated with [3-cydodextrin to reduce cholesterol produced completely random distributions of H-Ras. This cholesterol dependence suggests some type of coupling of rafts across the inner and outer membrane leaflets. 

TABLE 4.1 Effect of dietary psyllium on plasma and liver cholesterol concentrations in hamsters°... 

Terpstra, A. H. M., Lapre, J. A., de Vries, H. T., and Beynen, A. C. (1998). Dietary pectin with high viscosity lowers plasma and liver cholesterol concentration and plasma cholesteryl ester transfer protein activity in hamsters. /. Nutr. 128,1944-1949. 

Turley, S. D., and Dietschy, J. M. (1995). Mechanisms of LDL-cholesterol lowering action of psyllium hydrophillic mucilloid in the hamster. Biochim. Biophys. Acta 1255,177-184. 

Cholesterol metabolism. Hydrogenated oil, administered orally to hamsters at a dose of 20% of diet for 4 weeks, induced hypercholesterolemia. Oil feeding had no effect on cholesterol synthesis but markedly inhibited cholesterol esterification in both the liver and the intestine. The diet-induced hypercholesterolemia was strongly correlated with an increase in acyl-CoA/cholesterol acyltransferase activity. The hypercholesterolemia increased aortic uptake of cholesterol and hence acyl-CoA/cholesterol acyltransferase activity " Coconut fat, administered orally to rabbits with partial ileal bypass, produced a significant increase of serum total cholesterol and phospholipids concentrations. The effect on semm lipids of the type of fat was similar in control and partial ileal bypass rabbits A Coconut—a main source of energy for two... 

CN109 Jackson, B., A. N. Gee, M. Martinez-Cayuela, and K. E. Suckling. TTie effects of feeding a saturated fat-rich diet on enzymes of cholesterol metabolism CN120 in the liver, intestine and aorta of the hamster. Biochim Biophys Acta 1990 ... 

CN136 Alexaki, A., T. A. Wilson, M. T. Atallah, G. Handelman, and R. J. Nicolosi. Hamsters fed diets high in saturated fat have increased cholesterol accumulation and cytokine production in the aortic arch compared with cholesterol-fed hamsters with moderately elevated plasma non-HDL cholesterol concentrations. J Nutr 2004 134(2) 410-415. 

CN201 Trautwein, E. A., A. Kunath-Rau, J. Dietrich, S. Drusch, and H. F. Erbersdobler. Effect of dietary fats rich in lauric, myristic, palmitic, oleic or li-noleic acid on plasma, hepatic and biliary lipids in cholesterol-fed hamsters. Br J Nutr 1997 77(4) 605-620. 

Sanders, T. A. B., and S. Sandaradura. The cholesterol-raising effect of coffee in the Syrian hamster. Biol Reprod 1992 68(2) 431-434. 

Investigation of the effect of coffee lipids on serum cholesterol in hamsters. Food Chem Toxicol 1995 33(3) ... 

OE149 VanTol, A., A. E. H. Terpsta, P. Van Der Berg, and A. C. Beynen. Dietary corn oil versus olive oil enhances HDL protein turnover and lowers HDL cholesterol levels in hamsters. Atherosclerosis 1999 147(1) 87-94. 

Antigalactogogue effect. Dried kernel, administered to cows at a concentration of 50% of diet, was inactive . Antihypercholesterolemic activity. Seeds, administered orally to 20 adults with mild hypercholesterolemia at a dose of 5.1 g/day for 40 days, reduced LDL cholesterol by 8% and total cholesterol by 6% . Dried seed fiber, in the ration of Syrian hamster at a dose of 7.5% of diet, was active . Dried seed fiber, administered orally to adults at a dose of 10.2 g/day, was active . Dried seed fiber, administered orally to 50 healthy children 2 to 11 years of age at a dose of 6.4 g/ day for 12 weeks, was active The hydro-phobic colloid of the dried seed, administered in the ration of sea quails at a dose of 10% of diet, was active vs diet-inducing hypercholesterolemia . The seed hull, administered in the ration of genetically diabetic mice at a dose of 2.5% of diet for 18 weeks, was active. Total cholesterol was lower, and HDL-cholesterol higher in psyllium-fed than in placebo-fed animals . The seed hull, administered orally to 286... 

Cholesterol absorption inhibition. Fiber, administered in ration of male hamsters at a concentration of 7.5% of diet, was inact-Iygpoo33 Seeds, administered orally to 20 male adults with mild hypercholesterolemia at a dose of 5.1 g/day for 40 days, were active . 

Wang, Y.W., P.J. Jones, I. Pischel, and C. Fairow. Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters. Lipids 2003 38(2) 165-170. 

Friedman, M., Fitch, T. E., Levin, C. E., Yokoyama, W. Ft. (2000a). Feeding tomatoes to hamsters reduces their plasma low-density lipoprotein cholesterol and triglycerides. J. Food Set, 65, 897-900. 

Trautwein, E. A., Jurgensen, U., and Erbersdobler, H. F. (1997). Cholesterol-lowering and gallstone-preventing action of chitosans with different degrees of deacetylation in hamsters fed cholesterol-rich diets. Nutr. Res. 17,1053-1065. 

Burnett and coworkers have described the synthesis of a very potent class of cholesterol absorption inhibitors (CAI) typified by the original lead compound in this series the compound I showed in Fig. 42 (SCH 48461). This 2-azetidinone has resulted as an effective inhibitor of cholesterol absorption in a cholesterol-fed hamster model [9]. Subsequently, the same molecule has been shown to reduce serum cholesterol in human clinical trials [382]. Although this class of compounds has been initially designed as acyl coenzyme A cholesterol transferases (ACAT) inhibitors, early structure-activity studies demonstrated a striking divergence of in vitro ACAT inhibition and in vivo activity in the cholesterol-fed hamster. A detailed examination of this molecule indicated that the hypocholesterolemic... 

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