Antihypercholesterolemic activity

Antihypercholesterolemic activity. Gum, administered to female rats at a concentra-... 

Antigalactogogue effect. Dried kernel, administered to cows at a concentration of 50% of diet, was inactive . Antihypercholesterolemic activity. Seeds, administered orally to 20 adults with mild hypercholesterolemia at a dose of 5.1 g/day for 40 days, reduced LDL cholesterol by 8% and total cholesterol by 6% . Dried seed fiber, in the ration of Syrian hamster at a dose of 7.5% of diet, was active . Dried seed fiber, administered orally to adults at a dose of 10.2 g/day, was active . Dried seed fiber, administered orally to 50 healthy children 2 to 11 years of age at a dose of 6.4 g/ day for 12 weeks, was active The hydro-phobic colloid of the dried seed, administered in the ration of sea quails at a dose of 10% of diet, was active vs diet-inducing hypercholesterolemia . The seed hull, administered in the ration of genetically diabetic mice at a dose of 2.5% of diet for 18 weeks, was active. Total cholesterol was lower, and HDL-cholesterol higher in psyllium-fed than in placebo-fed animals . The seed hull, administered orally to 286... 

Antihypercholesterolemic activity. Oleo-resin, administered orally to rats, was active vs cholesterol-primed animals . Ethanol (95%) extract of the dried rhizome, administered intragastrically to male rabbits at a dose of 200 mg/kg, was active vs cholesterol-fed animals ° °h... 

L-Triiodothyronine was used as a standard in the evaluation of the hypo-cholesterolemic effect of thyromimetic compoimds by Greenberg et al. [190]. These workers have shown that using pooled samples of blood from thyromimetic-treated animals, a reduction by 38 mg/100 ml of cholesterol concentration in plasma is required in order to achieve results having statistical significance (P = 0.01). A dose of 1.5-3.0 [xg/kg/day of L-T3 consistently caused such a depression in the rat. The antihypercholesterolemic activity of L-T3 has been assigned the arbitrary value of 1. 

Ikeda, I, Kawasaki, A, Samezima, K and Sugano, M (1981) Antihypercholesterolemic activity of beta-sitostanol in rabbits. J. Nutr. Sci. Vitaminol. (Tokyo), 27, 243-251. 

Effects with the autonomous nervous system have also merited attention. Over the cardiovascular system anti arrhythmic 341), antieschemic (555), antihemorrhagic 348), antifibrillatory 346), PAF inhibition 435), vasorelaxant 449), and hypotensive activities (552) are some of the important biological effects reported for the protober-berine alkaloids in the period covered by this review. Also important to mention are the metabolic effects hypoglycemic 351,404), antihypercholesterolemic 350), bone resorption inhibition (5(56), osteoclast formation inhibition (566), lipase and lipogenesis inhibition 412,414), and prostaglandin synthesis inhibition 438), are a few of the reported activities related to metabolism. 

Saponins are generally reported to have widely different (both in kind and in intensity) pharmacological and biological activities. Some of the more important activities include hemolytic (strong in vitro, much weaker in vivo)," local irritant, inflammatory (e.g., on intestine), anti-inflammatory antimicrobial, cytotoxic, and antihypercholesterolemic in laboratory animals (also see alfalfd). It was recently shown that an aqueous extract of quillaia possessed marked cytopro-tective against cellular infection by vaccinia virus, HSV-1, varicella zoster, HIV-1 and -2, and reovirus. The demonstrated activity was achieved at 0.1 lg/mL, which was... 

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