Haloperidol amisulpride

Economic data relating to amisulpride are very few, despite the longstanding availability of this dmg in France. There appears to be only one published economic evaluation—a comparison with haloperidol (Souetre et al, 1992). In this French study, direct medical... 

Amisulpride is a substituted benzamide, which acts as a highly selective blocker of D2 and D3 receptors (Kerwin, 2000). As with all the other drugs, it can easily be demonstrated to be effective compared with placebo and haloperidol, with a lower extrapyramidal symptom profile (Moller et al, 1995). The strength of amisulpride lies in the quality of the evidence to show that it is effective against primary negative symptoms and affective symptoms. Two studies have shown convincing superiority for negative symptoms... 

Erythromycin (especially intravenous use), halofantrine, some quinolones Amisulpride, haloperidol, sertindole, thioridazine, pimozide Cisapride... 

Chlorpromazine and clozapine at low doses lead to an increase in slow (delta, theta) waves and a decrease in alpha activity in the pharmaco-EEG of healthy subjects. Findings regarding beta activity are less uniform. Rohloff et ul. (1992) reported on an increase in slow frequency components and a decrease of alpha and beta activity after 4.0 mg of haloperidol. Low doses of amisulpride (up to 50 mg) were reported to display an alertness-enhancing effect (Rosenzweig et ul., 2002). 

Legangneux, E., McEwen, J., Wesnes, K., et a/. The acute effects of amisulpride (50 and 200mg) and haloperidol (2mg) on cognitive function in healthy elderly volunteers. J. Psvchopharmacol. 14, 164-171, 2000. 

Ramaekers, J.G., Louwerens, J.W., Munjewerff, N.D., et al. Psychomotor, cognitive, extrapyramidal, and affective functions of healthy volunteers during treatment with an atypical (amisulpride) and a classic (haloperidol) antipsychotic. J. Clin. Psychopharmacol. 19, 209-221, 1999. 

Peretti, C. S., Danion, J. M., Kauffmann-Muller, R, Grange, D., Patat, A., Rosenzweig, P. 1997, Effects of haloperidol and amisulpride on motor and... 

Fig. 13.1 Chemical structure of clozapine, some of its structural analogues, typical (chlorpromazine, haloperidol) and atypical antipsychotics (risperidone, ziprasidone, sertindole and amisulpride) unrelated to clozapine.

First-generation (typical) antipsychotics include amisulpride, chlorpromazine, fluphenazine, haloperidol, promethazine, promazine, trifluoperazine... 

Fixed doses of amisulpride (100, 400, 800, and 1200 mg/ day) and haloperidol (16 mg/day) have been compared in a 4-week, double-blind, randomized trial in 319 patients with acute exacerbations of schizophrenia (33). Amisulpride 400 mg/day and 800 mg/day was effective in treating the positive symptoms of schizophrenia, with fewer extrapyramidal adverse effects than haloperidol,... 

The results of 11 studies in 1933 patients with schizophrenia, who were randomly assigned to amisulpride (n = 1247), haloperidol (n = 309), risperidone (n = 113), flupenthixol (n = 62), or placebo (n = 202) have been reviewed (45). Extrapyramidal signs occurred in 15% of those given amisulpride (n = 579), 12% of those given risperidone (n = 113), and 31% of those given haloperidol (n = 214). In contrast, endocrine disorders were more frequent with amisulpride (4%) and risperidone (6%) than with haloperidol (1%). In a subgroup of patients with predominant negative schizophrenia who had at... 

Puech A, Fleurot O, Rein W. Amisulpride, and atypical antipsychotic, in the treatment of acute episodes of schizophrenia a dose-ranging study vs. haloperidol. The Amisulpride Study Group. Acta Psychiatr Scand 1998 98(l) 65-72. 

In a randomized, double-blind, crossover study in 21 healthy volunteers who took amisulpride 50 mg/day, amisulpride 400 mg/day, haloperidol 4 mg/day, or placebo, amisulpride 400 mg had several adverse effects on psychomotor performance and cognitive performance, similar to those of haloperidol, at the end of the 5-day course of treatment however, there were no signs of mental disturbances on clinical rating scales or during a structured psychiatric interview (17). 

FLECAINIDE ANTIPSYCHOTICS -PHENOTHIAZINES, AMISULPRIDE, PIMOZIDE, SERTINDOLE Risk of arrhythmias Additive effect. Also, haloperidol and thioridazine inhibit CYP2D6-mediated metabolism of flecainide Avoid co-administration... 

Two narrative reviews of amisulpride have been published (4,5). The authors emphasized that amisulpride in low dosages (below 300 mg/day) causes a similar incidence of adverse effects to placebo nevertheless, at higher dosages (400-1200 mg/day), the overall incidence of adverse events in those taking amisulpride was similar to that in patients taking haloperidol, flupenthixol, or risperidone. The most commonly reported adverse events associated with higher dosages of amisulpride were extrapyramidal... 

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