Guanylate

The ANP leceptoi exists in two forms, ANP and ANPg, both of which have been cloned. These membrane-bound guanylate cyclases have a single transmembrane domain, an intracellular protein kinase-like domain, and a catalytic cyclase domain, activation of which results in the accumulation of cychc guanosine monophosphate (cGMP). A third receptor subtype (ANP ) has been identified that does not have intrinsic guanylate cyclase activity and may play a role in the clearance of ANP. 

Clindamycin 3-phosphate [28708-34-17, antibacterially inactive in vitro, and the ribonucleotides clindamycin 3-(5 -cytidylate) [31186-90-0], clindamycin 3-(5 -adenylate) [31186-91-1], clindamycin 3-(5 -uridylate) [36010-69-2], and clindamycin 3-(5 -guanylate) [36010-70-5], all inactive in vitro, can be generated... 

Although the stmctures of ribavirin and selenazofutin are similar, they appear to exert their antiviral action at different enzyme sites along the same biochemical pathway. Selenazofutin forms the nicotinamide adenosiae dinucleotide (NAD) analogue, which inhibits IMP dehydrogenase by binding ia place of the NAD cofactor, and hence this potent reduction of guanylate pools is responsible for the antiviral effect of selenazofutin. 

DMTr = 4,4 -dimethoxytrityl Bj, 83, B3, B4 = adenyl, cytidyl, guanyl, thymidyl... 

Synthesis of l-guanyl-3-methylpyrazole (29) (86% yield) from pyrazole 13 and aqueous cyanamide has been claimed (94GEP4237687). 

The same compound (28) can be prepared from an A -guanyl or A -nitroguanyl derivative of 3-aminopropanol. ° Also A -(3-hydroxy-... 

Lefkowitz, R. J., Mullikin, D., and Caron, M. G. (1976). Regulation of P-adrenergic receptors by guanyl-5 -yl imidodiphosphate and other purine nucleotides. J. Biol. Chem. 251 4686-4692. 

Adaptor Proteins. Figure 1 Adaptor protein domains. A scheme of the domain structures of some well-characterized adaptor proteins is shown. Descriptions of domain characteristics are in main text except C2, binds to phospholipids GTPase activating protein (GAP) domain, inactivates small GTPases such as Ras Hect domain, enzymatic domain of ubiquitin ligases and GUK domain, guanylate kinase domain. For clarity, not all domains contained within these proteins are shown. 

A second class of neuronal calcium sensors is formed by the guanylate cyclase-activating protein (GCAP). The GCAPs are expressed only in the photoreceptor cells of the retina of vertebrates. Recoverins and GCAPs have antagonistic roles in phototransduction. 

A half-sandwich titanacarborane guanidinate complex is formed on treatment of the corresponding amide precursor with 1,3-dicyclohexylcarbodiimide (Scheme 106). The compounds have been employed as catalysts for the guanylation of amines (cf. Section V.C). ... 

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