Carbon monoxide guanylate cyclase activation

Brune, B., Ullrich, V. (1987). Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase. Mol. Pharmacol. 32 497-504. 

It has been suggested that carbon monoxide (CO) is an activator of soluble guanylyl cyclase in Purkinje cells. Heme oxygenase-2, which degrades heme to biliverdin and releases carbon monoxide in the process, was shown to be co-localized with guanyl cyclase in rat Purkinje and granule cells with in situ hybridization histochemistry (Verma et al., 1993). 

Stone, J. R., and Marietta, M. A. (1994). Soluble guanylate cyclase from bovine lung— Activation with nitric oxide and carbon monoxide and spearal characterization of the ferrous and ferric states. Biochemistry 33, 5636-5640. 

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