Nitric oxide guanyl cyclase activated

W. P., Katsuki, S., Kimura, H., Guanylate cyclase activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by... 

Nitric oxide (NO) is synthesized by vascular endothelium in response to vasodilators. It diffuses into the surrounding vascular smooth muscle, where it directly binds the heme group of soluble guanylate cyclase, activating the enzyme. 

Craven, P. A., and DeRubertis, F. R. (1978). Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and heme proteins Evidence for the involvement of the paramagnetic nitrosyl-heme complex in enzyme activation. J. Biol. Chem. 253, 8433-8443. 

Kojda, G., Laursen, J.B., Ramasamy, S., Kent, J.D., Kurz, S., Burchfield, J., Shesely, E.G., Harrison, D.G. Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial cell nitric oxide synthase contributions of NOS isoforms to blood pressure and heart rate control, Cardiovasc. Res. 1999, 42, 206-213. 

Gruetter, C., Barry, BK, McNamara, DB, Kadowitz, PJ, and Ignarro, LJ. 1980. Coronary arterial relaxation and guanylate cyclase activation by cigarette smoke, N -nitrosonomicotine and nitric oxide. J Pharmacol Exp Ther 214 9-15. 

Lewicki, J. A., Brandwein, H. J., Mittal, C. K., Arnold, W. P., and Murad, F. (1982). Properties of purified soluble guanylate cyclase activated by nitric oxide and sodium nitroprusside. J. Cyclic Nucleotide Res. 8, 17-25. 

As yet, it has not been possible to pinpoint the exact site of injury to the L-arginine nitric oxide pathway. The defect may lie with the surface receptors, signal transduction, L-arginine deficiency, nitric oxide synthase, tolerance of smooth muscle, physical obstruction to the diffusion of nitric oxide by a thickened intima, or impaired guanylate cyclase activation. However, endogenous guanylate cyclase can be activated by exogenously administered nitric oxide to relax smooth muscle, even when unresponsive to acetyl-... 

Severina, I.S., Belushkina, N.N., and Grigoryev, N.B. (1994). Inhibition of Adp-induced human platelet aggregation by a new class of soluble guanylate cyclase activators capable of nitric oxide generation. Biochem. Mol. Biol. Int. 33, 957-967. 

Figure 13.9 The production and actions of nitric oxide (NO). The influx of calcium through either calcium channels or NMDA receptors triggers NOS to convert L-arginine to NO. L-NAME and 7-NI inhibit this process. NO, once produced, can diffuse in a sphere and then can activate guanylate cyclase...

Acetylcholine-mediated parasympathetic activity leads to production of the non-adrenergic-non-cholinergic transmitter nitric oxide. By enhancing the activity of guanylate cyclase, nitric... 

---