Guanylate cyclase effects

Ohlstein, E. H., Wood, K. S., and Ignarro, L. J. (1982). Purification and properties of heme-deficient hepatic soluble guanylate cyclase Effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX. Arch. Biochem. Biophys. 218, 187-198. 

EAggEC children in the developing world 20-48 h persistent FliC - inflammation EAST-1 - guanylate cyclase -t secretion heat-labile toxin Ca2+-dependent actin phosphorylation cytoskeletal damage Pet - histopathologic effects on human intestinal mucosa... 

Penile erection occurs by relaxation of the smooth muscle of the corpus cavernosum, increasing blood flow into the penis and producing erection and rigidity. In a parallel fashion, vaginal pressure stimulation increases blood velocity and flow into clitoral arteries (Lavoisier et al. 1995). Cavernosal vasodilation is accomplished by neurotransmitters released from the cavernosal nerve and endothelial cells. One of the most important transmitters in this cascade is nitric oxide (NO), which induces synthesis of cyclic GMP from guanylate cyclase (Rajfer et al. 1992). Thus, ginkgo s vascular mechanisms could be responsible for some of the putative sexual effects. 

In human volunteers significant lung vasodilator effects have been observed at 10-40 ppm. Studies indicate that nitric oxide stimulates guanylate cyclase, which leads to smooth muscle relaxation and vasodilation. Because... 

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