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Guanyl transferase

GTP CYCLOHYDROLASES GUANYLATE CYCASE HEXOSE-1-PHOSPHATE GUANYLYL-TRANSFERASE... [Pg.747]

Kim, D.H. Guengerich. F.P. (1990) Formation of the DNA adduct 5-[2-(,V7-guanyl)ethyl]-glutathione from ethylene dibromide effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation. Carcinogenesis, 11, 419-424... [Pg.665]

ThiolMP and ThioGMP are feedback inhibitors of phosphoribosylpyrophosphate amido-transferase, which is the first, and rate-limiting step in the synthesis of purine. In addition, these analogs inhibit the de novo biosynthesis of purine and block the conversion of inosinic acid to adenylic acid or guanylic acid. The triphosphate nucleotides are incorporated into DNA, and this results in delayed toxicity after several cell divisions. [Pg.115]

The reaction that catalyzes the conversion of ribosyl pyrophosphate to 5 -phosphoribosylamine is likely to be the rate-limiting step in purine biosynthesis. Of course, it is difficult to pinpoint a rate-limiting step in an intact mammal, but in vitro experiments have established a feedback inhibition of glutamine phosphoribosyl pyrophosphate amino transferase by adenylic and guanylic nucleotides (ATP, ADP, GMP, GDP, and IMP). [Pg.222]

See other pages where Guanyl transferase is mentioned: [Pg.271]    [Pg.209]    [Pg.271]    [Pg.209]    [Pg.312]    [Pg.149]    [Pg.14]    [Pg.56]    [Pg.215]    [Pg.232]    [Pg.149]    [Pg.1]    [Pg.48]    [Pg.714]    [Pg.236]    [Pg.312]    [Pg.305]    [Pg.245]    [Pg.245]    [Pg.213]    [Pg.578]   
See also in sourсe #XX -- [ Pg.256 ]



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