Growth Metabolic effect

Studies in rats have shown effects of lead on bone mineralization and bone growth. The effects observed in rats may be relevant to our understanding of the mechanisms for the growth deficits that have been associated with low-level in utero and childhood lead exposures. Additional studies of the effects of lead on bone metabolism in humans and in animal models would improve our understanding of the toxicological significance of lead in bone. 

However, at the introduction of C60/PVP complex (up to 5 pg/ml) into the cultivating media during cell growth no effects were observed. In the cell MA-104 (cell line derived of green monkey kidney epithelium) grown normally within 3-6 days, no morphological changes and cell metabolism intensiveness were observed (Table 7.1). 

Insulin aspart is absorbed nearly twice as fast as regular insulin. In addition to binding to the insulin receptor, insulin aspart also binds to the insuUnlike growth factor (IGF-1) receptor, which shares structural homology with the insulin receptor. However, at physiological and pharmacological levels, the metabolic effects of insulin aspart predominate. Both lispro insulin and insulin aspart have relatively fast onsets and short... 

Mechanism of Action. The mechanisms by which antibiotic administration at subtherapeutic levels enhance growth rate and efficiency of gain in growing animals have not been clarified. Possible modes of action include disease control, nutrient sparing, and metabolic effects. There is extensive evidence that the principal benefit from subtherapeutic use of antibiotics results from the control of harmful microoiganisms. 

Children whose mothers used depot medroxyprogesterone acetate while breastfeeding have been followed up in Thailand for 17 years and in Chile for 4.5 years, with no documented effect on growth or development (36). In undernourished lactating women the metabolic effects seem to be more pronounced than among healthy users (17). 

Haffner D, Nissel R, Wuhl E, Schaefer F, Bettendorf M, Tonshoff B, Mehls O. Metabolic effects of long-term growth hormone treatment in prepubertal children with chronic renal failure and after kidney transplantation. 

Hayakawa M, Shimazaki Y, Tsushima T, Kato Y, Takano K, Chihara K, Shimatsu A, Irie M. Metabolic effects of 20-kilodalton human growth hormone (20k-hGH) for adults with growth hormone deficiency results of an exploratory uncontrolled multicenter clinical trial of 20k-hGH. J Clin Endocrinol Metab 2004 89 1562-71. 

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