Green process reaction design

This chapter has presented a quantitative assessment of the environmental impact of two alternative procedures for the preparation of Elliott s alcohol. The assessment was made with the aid of the EATOS tool. This is an easy to use software tool that can be used routinely to assess the greenness of reactions or synthetic schemes. Its simplicity allows for a daily routine use, thus favoring the introduction of green elements at a very early stage of synthetic process design. 

A reaction under neat conditions, with or without catalyst, avoiding the use of organic solvents in the entire operation, including isolation and purification, is of great significance in the design of a green process for industrial application. 

Synthetic Methodology Assessment for Reduction Techniques (SMART) A program adapted from the EPAs SMART review process and designed to quantify and categorize hazardous materials used in a manufacturing process. Green Synthetic Reactions Provides a searchable database of synthetic processes and identifies alternative processes published to replace more hazardous materials with less hazardous ones. 

Host-guest inclusion complexations are usually carried out in organic solvents. As a green process, inclusion complexation can be performed in a water suspension medium or in the solid state. When the solid-state reaction in a water suspension medium is combined with an enantioselective inclusion complexation in the same water medium, a one-pot green preparative method for obtaining optically active compounds can be designed. In all these cases, enantiomers separated as inclusion complexes are recovered by distillation of the inclusion complex. When enantioselective inclusion complexation in the solid state is combined with the distillation technique, a unique green process for enantiomeric separation can result. 

Green chemistry involves design of chemical synthesis to prevent pollution and thereby, solve the environmental problems. The microwave chemistry is a current approach in green chemistry. Microwave-mediated reactions occur more rapidly, safely and in environment-friendly manner with high yields. Such reactions reduce the amount of waste products and increase the pure required products. Thus, one can conclude that microwave-mediated synthesis is a green chemical technology because microwave not only accelerate chemical processes but also improve yield, selectivity, reduces pollution and enable reaction to occur in solvent-free conditions. 

Design of catalytic reaction fields toward green chemical processes... 

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