Granulation pelletization

Description A body of solids in which the particles, consisting of granules, pellets, beads, or briquettes, flow downward by gravity at... 

Particle size distribution/physical form, e.g. fine powder, flakes, granules, pellets, prills, lumps Porosity... 

The particle density and bulk density of AN particulates (prills, granules, pellets) are reflected in the density of the cast Minol II prepd. The highest Minol 11 density is attained thru use of... 

Capsules— These are primarily intended for oral administration and are solid preparations with hard or soft shells comprised of gelatin or hydrox-ypropyl methyl cellulose and small amounts of other ingredients such as plasticizers, fillers, and coloring agents. Their contents may be powders, granules, pellets, liquids, or pastes. 

Formulations of chlorpyrifos include emulsifiable concentrates, wettable powders, granules, pellets, microencapsulates, and impregnated materials. Suggested diluents for concentrates include water and petroleum distillates, such as kerosene and diesel oil. Carrier compounds include synthetic clays with alkyl/aryl sulfonates as wetting agents (Table 14.1). Little information is available to assess the influence of various use formulations on toxicity, dispersal, decomposition, and bioavailability. Chemical and other properties of chlorpyrifos are summarized in Table 14.2 and Figure 14.1. 

Hardness of a solid (granule, pellet, or tablet) (i.e., related to amount of compression used to make tablet) or capsule if they do not disintegrate appropriately. 

Impulse 0.4-400 1 to 2 Free-flowing powders. Granules/pellets <13 mm in size. 

In comparison to the approach of Ginski et al. [48], the Miyazaki s method appears to be more elaborate and complex and is thus coming closer to the in vivo situation. The device can simulate various effects of pH on dissolution and is, as an open system, closer to in vivo conditions compared to a closed one. However, it exhibits the drawback of not freely adjustable pH values acting on the drug. Low flow rate in the dissolution vessel may limit applications of complete dosage forms and allows predominantly only the use of granules, pellets, or grinded tablets. Furthermore, the application of compendial dissolution devices appears to be a more robust approach. 

Sorbitol is an odorless powder that is white or almost colorless. Various grades based on particle size are available, and it is obtained in various forms such as flakes, granules, pellets, or powder. 

The sorbitol solution produced from hydrogenation is purified in two steps [4]. The first involves passing the solution through an ion-exchange resin bed to remove gluconate and other ions. In the second step, the solution is treated with activated carbon to remove trace organic impurities. The commercial 70% sorbitol solution is obtained by evaporation of the water under vacuum. The solid is prepared by dehydration until a water-free melt is obtained which is cooled and seeded. The crystals are removed continuously from the surface (melt crystallization). The solid is sold as flakes, granules, pellet, and powder forms in a variety of particle size distributions. 

Porous carbon materials mostly consist of carbon and exhibit appreciable apparent surface area and micropore volume (MPV) [1-3], They are solids with a wide variety of pore size distributions (PSDs), which can be prepared in different forms, such as powders, granules, pellets, fibers, cloths,... 

Granules, pellets, and tablets can be filled into capsules using automatic-filling machines. Products are prepared in these forms to modify the release rates of active ingredients, separate incompatible components, or densify a product to achieve the fill weight in a specific size of capsule. 

Most of the samples being investigated by SEM in the field of pharmaceutical technology are powders prepared by different methods, granules, pellets, tablets, and films from coated tablets. The sample preparation of bulk materials includes the following steps ... 

Bioavailability enhancer Tablets, capsules, granules, pellets, suppositories, transder-mal systems... 

Fig. 5.1 Schematic representations of the three most common melt solidification processes, (a) Prilling [B.42], (b) pastillation (courtesy Sandvik, Totowa, NJ, USA), (c) underwater granulation/ pelletizing (courtesy Gala, Eagle Rock, VA, USA).

Figure 4. Sintered hydroxylapatite as powder, granules, pellets and other forms for implantation into bone and soft tissue.

---