Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Golden liver

NPYR Syrian golden hamster Liver microsomes enhanced a-hydroxylation and mutagenicity in ethanol-consuming hamsters 10... [Pg.56]

These studies on NPYR are typical of the state of the art in cyclic nitrosamine metabolism ai d activation. The major metabolic pathways have been rather well characterized, but data on the relationship of these pathways to carcinogenesis are limited. This is especially true of the organospecific effects of NPYR and the other cyclic nitrosamines. For example, the main target organs for NPYR in the Syrian golden hamster are the trachea and nasal cavity rather than the liver. This is in spite... [Pg.61]

NPIP induces esophageal and nasal cavity tumors in the rat, forestomach, liver and lung tumors in the mouse, and tracheal tumors in the Syrian golden hamster (43, 44, 45). Its potent carcinogenicity is indicated by the fact that a single dose of only 22 mg/kg was sufficient to induce tumors in 20% of Syrian golden hamsters (45). The environmental occurrence of NPIP appears to be less frequent than that of NPYR, but it has been detected in food (J, 44). [Pg.66]

NHEX is a potent carcinogen which induces tumors of the liver and esophagus in rats, and tumors of the trachea in Syrian golden hamsters (50, 51). It has not been detected in the environment. ... [Pg.67]

Genotoxic Effects. The Ames test with Salmonella typhimurium with and without s9 liver fractions from male Syrian golden hamsters or Sprague-Dawley rats indicates that hydrogen sulfide is not a mutagen (EPA 1984). A summary of genotoxicity studies is presented in Table 2-3. [Pg.108]

Golden eagle, Aquila chrysaetos liver vs. eggs total PCBs Norway, 1965-83 dead on collection Grey heron, Ardea cinerea England 1988-90 total PCBs (35 congeners) 2000 (<100-250,000) FW vs. 1000 (400-5700) FW 1... [Pg.1289]

The hepatocarcinogenicity of dieldrin in mice has been confirmed in several experiments, and in some cases, the liver cell tumors metastasized. No excess of tumors has been observed in a number of bioassays in rats and one bioassay in Syrian golden hamsters. ... [Pg.243]

Tomatis L, Magee PN, Shubik P Induction of liver tumors in the Syrian golden hamster by feeding dimethylnitrosamine. J Natl OtwcerZ/wt 33 341-345, 1964... [Pg.533]

Golden eagle, Aquila chrysaetos liver vs. eggs total PCBs Norway, 1965-83 dead on collection... [Pg.1289]

DVA, DNA-protein cross-links, Syrian golden hamster liver in vivo - 3923 ppm inh 6 h/d. Casanova ef al. o... [Pg.289]

Hamster (Golden Syrian) 7 d (F) Hepatic 2686 (36% increase in relative liver weight) Hosokawa et al. 1994... [Pg.51]

In intermediate-duration animal studies, golden Syrian hamsters exposed to camotite uranium ore dust (AMAD=1.5-2.1 pm) at a concentration of 19 mg U/m by inhalation for 16 months failed to shown signs of cancer development upon examination of selected tissues including lungs, trachea, liver, kidneys, spleen, heart, and any abnormal tissue. As compared to unexposed controls, the hamsters had significantly more necrotic liver foci and inflammatory lung responses (Cross et al. 1981b). [Pg.105]

See other pages where Golden liver is mentioned: [Pg.356]    [Pg.259]    [Pg.356]    [Pg.259]    [Pg.69]    [Pg.28]    [Pg.62]    [Pg.62]    [Pg.66]    [Pg.270]    [Pg.72]    [Pg.126]    [Pg.172]    [Pg.101]    [Pg.142]    [Pg.102]    [Pg.1302]    [Pg.179]    [Pg.240]    [Pg.294]    [Pg.302]    [Pg.449]    [Pg.102]    [Pg.1302]    [Pg.70]    [Pg.439]    [Pg.696]    [Pg.1003]    [Pg.1003]    [Pg.1122]    [Pg.1240]    [Pg.494]    [Pg.386]    [Pg.217]    [Pg.628]    [Pg.104]    [Pg.123]    [Pg.44]    [Pg.105]    [Pg.8]   
See also in sourсe #XX -- [ Pg.259 ]



SEARCH



Golden

© 2024 chempedia.info