Gold thiomalate

Shaw, C.F. Ill, Schaeffer, N.A., Elder, R.C., Eidsness, M.K., Trooster, J.M. and Calls, G.H.M. (1984) Bovine serum albumin-gold thiomalate complex gold-197 Moessbauer, EXAFS and XANES, electrophoresis, sulfur-35 radiotracer, and fluorescent probe competition studies. Journal of the American Chemical Society, 106, 3511-3521. 

Bau, R. (1998) Crystal structure of the antiarthritic drug gold thiomalate (Myochrysine) A double-helical geometry in the solid state. Journal of the American Chemical Society, 120, 9380-9381. 

Formula Gold(l) sodium thiomalate is a mixture of monosodium- and disodium-salts of gold thiomalate the respective molecular formulas being C4H4AuNa04S (monosodium salt) and C4H3AuNa204S (disodium salt) a tetrameric structure with S— Au—S linear units. 

A very large number of copper compounds have been tested for antiinflammatory activity, and various copper complexes of antiarthritic drugs have been found to be more effective than the parent drugs alone (including aspirin, D-penicillamine, ketoprofen and gold thiomalate).25... 

In rheumatoid arthritis the most commonly used gold salts are sodium aurothiomalate and aurothioglucose (3). There is some reason to believe that adverse effects are less frequent with the suspensions (of aurothioglucose or aurothiosulfate) than with the more rapidly absorbed solution (of sodium gold thiomalate) (SEDA-16, 233) (4). 

Gold thiomalate IM 10-mg test dose, then weekly dosing 25-50 mg after response may increase dosing interval Baseline and until stable UA, CBC with platelets preinjection Same as initial every other dose... 

Connective tissue diseases can result in protein denaturation whose degradation may be antigenic and causative of RA s inflammation. Gold compounds, interacting with such proteins, may help stabilize them. A protective ability of gold thiomalate toward heat-caused gammaglobulin aggregation can be demonstrated. 

Penicillamine, thiomalate and sodium gold thiomalate modulation of copper metabolism 535... 

PENICILLAMINE, THIOMALATE AND SODIUM GOLD THIOMALATE MODULATION OF COPPER METABOLISM... 

Mercaptosuccinic acid, monogold (1+) sodium salt Butanedioic acid, mercapto-, monogold (1+) sodium salt (A mixture of the mono- and di-sodium salts of gold thiomalic acid) Gold Sodium Thiomalate USP ... 

Gold thiomalate displaces Zn and Cd from the protein in a biphasic reaction. Zn " is displaced in preference to Cd " when gold is limiting, and complete displacement of both metal ions is possible when excess AuSTm is... 

Gold sodium thiomalate (actually a mixture of mono- and disodium salts of gold thiomalic acid) is very water soluble. It is available as a light-sensitive, aqueous solution of pH 5.8 to 6.5. The gold content is approximately 50%. It is administered IM, because it is not absorbed on oral administration and is highly bound (95%) to plasma proteins. 

In the absence of HCN in the blood of a patient the drug AuTm (gold -thiomalate) reacts with AlbSH to form AlbS—Au —Tm. In the presence of HCN which accumulates in the blood of smokers, the fg—Au—CN species are formed and disproportionate to Au(CN)2, changing the metabolism of gold drugs and causing a sequence of toxic reactions . ... 

E. Jellum and E. Munthe, Is the mechanism of action during treatment of rheumatoid arthritis with penicillamine and gold thiomalate the same in "Perspectives in Inflammation. Future trends and developments", D. A. Willoughby, J. P. Giroud and G. P. Velo, eds., MTP-Press Ltd, Lanchester,... 

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