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Drugs, gold

This mechanism only requires [Au(CN)2] to be a highly transient metabolite , generated locally from administered gold drugs and in turn perhaps largely metabo-lized/decomposed locally. [Pg.295]

Hill, D.T, Sutton, B.M., Isab, A.A., Razi, T, Sadler, P.J., Trooster, J.M. and Calls, G.H.M. (1983) Gold- 197 Mossbauer Studies of Some Gold(I) Thiolates and Their Phosphine Complexes Including Certain Antiarthritic Gold Drugs. Inorganic Chemistry, 22, 2936-2942. [Pg.311]

Grootveld, M.C. and Sadler, P.J. (1983) Differences between the structure of the antiarthritic gold drug Myocrisin in the... [Pg.311]

Brown, D.H. and Smith, W.E. (1980) The chemistry of the gold drugs used in the treatment of rheumatoid arthritis. Chemical Society Reviews, 9, 217-239. [Pg.314]

Gold drugs used in the treatment of rheumatoid arthritis. Perspectives on Bioinorganic Chemistry, 1,... [Pg.317]

A common metabolite found in the urine and plasma of patients treated with gold drugs is [Au(CN)2], an ion which readily enters cells and can inhibit the oxidative burst of white blood cells. It may therefore be an active metabolite of gold drugs. It also exhibits anticancer and anti-HIV activity. The high Au contents of red blood cells of smokers receiving gold therapy has been attributed to the inhalation of HCN in smoke (420). [Pg.254]

The Chemistry of Gold Drugs Used in the Treatment of Rheumatoid Arthritis 14... [Pg.863]

The complexes which have been used in chrysotherapy (the treatment of rheumatoid arthritis by gold drugs) are given in Table 9. Of these, (11), (12) and (18) are the most important. Complexes (11) and (12) were for many years dominant, but they must be administered parenterally, and the new drug (18) is unique in that it is therapeutically beneficial when administered orally.9-14 240... [Pg.875]

M. T. Razi, G. Otiko and P. J. Sadler, Ligand Exchange Reactions of Gold Drugs in Model Systems and in Red... [Pg.777]

Ekins S, Williams AJ (2010) When pharmaceutical companies publish large datasets an abundance of riches or fool s gold Drug Disc Today 15 812-815... [Pg.153]

Table 1 Protein complexes of gold drugs metabolites ... Table 1 Protein complexes of gold drugs metabolites ...
See other pages where Drugs, gold is mentioned: [Pg.39]    [Pg.210]    [Pg.283]    [Pg.289]    [Pg.304]    [Pg.307]    [Pg.312]    [Pg.314]    [Pg.344]    [Pg.361]    [Pg.1061]    [Pg.247]    [Pg.255]    [Pg.875]    [Pg.876]    [Pg.755]    [Pg.758]    [Pg.774]    [Pg.47]    [Pg.389]    [Pg.58]    [Pg.60]    [Pg.1107]    [Pg.5450]    [Pg.5450]    [Pg.5451]    [Pg.5451]    [Pg.5451]    [Pg.19]    [Pg.755]    [Pg.758]    [Pg.774]    [Pg.21]    [Pg.119]   
See also in sourсe #XX -- [ Pg.4 ]

See also in sourсe #XX -- [ Pg.119 ]

See also in sourсe #XX -- [ Pg.5 , Pg.875 ]

See also in sourсe #XX -- [ Pg.112 ]

See also in sourсe #XX -- [ Pg.217 , Pg.228 ]



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