Glycoprotein lib

Glycoprotein lib/ NSTE ACS, class lla recommendation for Active bleeding... 

Quinn MJ, Fitzgerald DJ. Long-term administration of glycoprotein lib/Iia antagonists. Am Heart J 1998 135 5107-12... 

Jackson SB Yuan Y Schoenwaelder SM, Mitchell CA. Role of the platelet integrin glycoprotein lib-llla in intracellular signalling. Thromb Res 1993 71 159-168. 

Fab fragment of chimeric monoclonal antibody 7E3 glycoprotein lib/ Ilia and vitronectin receptors... 

Coller BS, Peerschke El, Scudder LE, Sullivan CA (1983) A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins lib and/or Ilia. J Clin Invest 72 325-338... 

GLYCOPROTEIN lib/ Ilia INHIBITORS ANTIHYPERTENSIVES AND HEART FAILURE DRUGS-VASODILATOR ANTIHYPERTENSIVES t risk of bleeding when eptifibatide ortirofiban is co-administered with iloprost Uncertain at present Closely monitor effects watch for signs of excess bleeding... 

GLYCOPROTEIN lib/ Ilia INHIBITORS PERIPHERAL VASODILATORS Possible t risk of bleeding with cilostazol Additive effect cilostazol has antiplatelet activity Warn the patient to report any signs of t bleeding... 

GLYCOPROTEIN lib/ Ilia INHIBITORS THROMBOLYTICS 1. t risk of major haemorrhage when co-administered with alteplase 2. Possible t risk of bleeding complications when streptokinase is co-administered with eptifibatide 1. Uncertain other thrombolytics do not seem to interact 2. Additive effect 1. Avoid co-administration 2. Watch for bleeding complications. Risk-benefit analysis is needed before co-administering this will involve the availability of alternative therapies such as primary angioplasty... 

Gulino D, Boudignon C, Shang L, et al. Ca(2-f-)-binding properties of the platdet glycoprotein lib ligand interaction domaia J Biol Chem 1992 267 1001-1007. 

Peerschke EIB. Stabilization of platdet-fibrinogen interactions is an integral prqKity of the glycoprotein lib-Illa complex. J Ld> Clin Med 1994 124 439-446. 

Peerscfake EIB. Glycoprotein lib and nia retention on fibrinogen-coated surfaces after lysis of adherent platelets. Blood 1995 82 3358-3363. 

Pytela RP, Pierschbacher MD, Ginsberg MH, Plow EF, Ruoslahti E. Platelet membrane glycoprotein lib/ma Member of a family of Arg-Gly-Asp-spedfic adhesion receptors Science 1986 231 155 1562. 

Chen Y-P, Djaffar I, Pidard D, Steiner B, Cieutat A-M, Caen JP, Rosa J-P Ser-7522Pro mutation in the cytoplasmic domain of int rin b, subunit and defective activation of platelet integrin a ,b, (glycoprotein lib-IIIa) in a variant of Glanzmann thrombasthenia. ProcNatl Acad Sd USA 89 10169-10173,1 2. 

BrayPF, RosaJP, LingappaVR, Kan YW, McEver RP, Shuman MA Biogenesis of the platelet recqrtor for fibrinogen Evidence for separate precursors for glycoproteins lib and Ilia. Proc Natl Acad Sd USA 83 1480-1484,1986. 

Bray PF, Barsh G, Rosa J-P, Juo XY, Magenis E, Shumtn MA Physical linkage of the genes for platelet memta-ane glycoproteins lib and Ilia Proc Natl Acad Sd USA 85 8683-8687,1988. 

Sosnodd DM, Emanuel BS, Hawkins AL, van Tuilen P, Ledbetter DH, Nussbaum RL, Kaos F-T, Sdiwartz E, Phillips DR, Bennett JS, Fitzgerald LA, Poncz M Chromosomal localization of the genes for ihe vitronectin and the fibronectin receptOTS a subunits and for platelet glycoprotein lib and Ilia J Clin Invest 81 1993-1998,1988. 

Hddenreidi R, Eisman R, Surrey S, Delgrosso K, Beimdt JS, Schwartz E, Poncz M Organization of the gene for platelet glycoprotein lib. Biochemistry 29 1232-1244,1990. 

PoikzM, Rianan R, Hddenreidi R, Silver SM, Vilaire G, Surrey S, Sdiwartz E, Bennett JS Sitructure of the platelet membrane glycoprotein lib. J Biol Chem 262 8476-8482,1987. 

Prandini M-H, Uzan G, Martin F, Thevenon D, Marguerie G Characterization of a specific erythro-megakaryocytic enhancer within the glycoprotein lib promoter. J Biol Chem 267 10370-10374,1992. 

Nurden AT, Didry D, Kieffer N, McEver RP Readud amounts of glycoproteins lib and Ilia may be present in the platdetsofmost patients with Glanzmann s thrombasthenia Blood 65 1021-1024,1985. 

Grimaldi CM, Chen FP, Wu CH, Weiss HJ, CoUer BS, French DL Glycoprotein lib Leu214Pro mutation prcxluces Glanzmaim thrombasthenia with both c]uantitative and qualitative abnormalities in GPlIb/IlIa Blood 91 1562-1571,1998. 

Sdigsohn U, CoUer BS, Zivelin A, Plow EF, Ginsberg MH Immunoblot analysis of platelet glycoprotein lib in patients with Glanzmann thrombasthenia in Israel. Br J Haematol 72 415-423,1989. 

Tomiyama Y, Kashiwagi H, Kosugi S, Shiraga M, Kanayama Y, Kurata Y, Matsuzawa Y Atmormal processing of the glycoprotein lib transcript due to a nonsense mutation in exon 17 assodated with Glanzmann s thrombasthenia Thromb Haemost 73 756-762,1995. 

Fitzgerald, L. and Phillips, D. R. Calcium regulation of platelet membrane glycoprotein lib-IHa... 

Indications Thrombotic arterial disease Category Antiplatelet Glycoprotein lib / Ilia inhibitor Half-life 10-30 minutes - given intravenously Clinically important, potentially hazardous interactions with fondaparinux, reteplase... 

TABLE 2 HPLC/UV Retention Times and Structures of EMD 122 347 (Glycoprotein lib/l I la Antagonist) and Related Impurities... 

Labinaz M, Ho C, Banerjee S, et al. Meta-analysis of clinical efficacy and bleeding risk with intravenous glycoprotein lib/ Ilia antagonists for percutaneous coronary intervention. Can J Cardiol 2007 12 963-70. 

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