Vasodilators antihypertensives

Direct vacuum gauges, 20 657 Direct vasodilators, antihypertensive agents, 5 165-166 Direct violet dyes, 9 406... [Pg.278]

Balazs, T. (1981). Cardiotoxicity of adrenergic bronchodililator and vasodilating antihypertensive drugs. In Cardiac Toxicology, Vol. II (Balazs, T., Ed.). CRC Press Boca Raton, FL, pp. 61-73. [Pg.358]

Coronary vasodilator antihypertensive Morsydomine. First mesoionic-type therapeutic agent... [Pg.738]

ACE INHIBITORS, ADRENERGIC NEURONE BLOCKERS, ALPHA-BLOCKERS, ANGIOTENSIN II RECEPTOR ANTAGONISTS, CENTRALLY ACTING AND VASODILATOR ANTIHYPERTENSIVES ... [Pg.34]

VASODILATOR ANTIHYPERTENSIVES NSAIDs Etoricoxib may t minoxidil levels Etoricoxib inhibits sulphotransferase activity Monitor BP closely... [Pg.35]

VASODILATOR ANTIHYPERTENSIVES CICLOSPORIN 1. Co-administration of bosentan and cidosporin leads to t bosentan and 1 cidosporin levels 2. Risk of hypertrichosis when minoxidil given with cidosporin 3. t sitaxentan levels 1. Additive effect both drugs inhibit the bile sodium export pump, which is associated with hepatotoxicity 2. Additive effect 3. Uncertain 1. Avoid co-administration of bosentan and cidosporin 2. Warn patients of the potential interaction 3. Avoid co-administration... [Pg.37]

VASODILATOR ANTIHYPERTENSIVES CORTICOSTEROIDS Risk of hyperglycaemia when diazoxide is co administered with corticosteroids Additive effect both drugs have a hyperglycaemic effect Monitor blood glucose closely, particularly with diabetes... [Pg.38]

VASODILATOR ANTIHYPERTENSIVES ANTICOAGULANTS -ORAL 1. Bosentan may 1 warfarin levels 2. Iloprost and sitaxentan may t warfarin levels 1. Uncertain postulated that bosentan induces CYP3A4 and 2C9 2. Uncertain Monitor INR closely... [Pg.38]

VASODILATOR ANTIHYPERTENSIVES ANTICOAGULANTS -PARENTERAL Possible t risk of bleeding with iloprost Anticoagulant effects of heparins t by a mechanism that is uncertain at present Monitor APTT closely... [Pg.38]

ADRENERGIC NEURONE BLOCKERS, ALPHA-BLOCKERS, CENTRALLY ACTING ANTIHYPERTENSIVES, VASODILATOR ANTIHYPERTENSIVES ASPIRIN 1 hypotensive effect not noted with low-dose aspirin Aspirin may cause sodium retention and vasoconstriction at possibly both renal and endothelial sites Monitor BP at least weekly until stable when high-dose aspirin is prescribed... [Pg.44]

VASODILATOR ANTIHYPERTENSIVES ASPIRIN t risk of bleeding when aspirin is co-administered with iloprost Uncertain at present Closely monitor the effects watch for signs of excess bleeding... [Pg.44]

VASODILATOR ANTIHYPERTENSIVES NNRTIs Risk of peripheral neuropathy when hydralazine is coadministered with didanosine, stavudine or zalcitabine Additive effect both drugs can cause peripheral neuropathy Warn patient to report early features of peripheral neuropathy if it occurs, the NNRTI should be stopped... [Pg.45]

VASODILATOR ANTIHYPERTENSIVES PROTEASE INHIBITORS t adverse effects of bosentan by ritonavir Inhibition of CYP3A4-mediated metabolism of bosentan Co-administration is not recommended... [Pg.45]

ACE INHIBITORS, ANGIOTENSIN II RECEPTOR ANTAGONISTS, CENTRALLY ACTING ANTIHYPERTENSIVES, VASODILATOR ANTIHYPERTENSIVES BETA-BLOCKERS t hypotensive effect Additive hypotensive effect may be used therapeutically Monitor BP at least weekly until stable. Warn patients to report symptoms of hypotension (light-headedness, dizziness on standing, etc.)... [Pg.46]

VASODILATOR ANTIHYPERTENSIVES BETA-BLOCKERS t hypotensive effect Additive hypotensive effect with diazoxide, hydralazine, minoxidil and sodium nitroprusside. In addition, hydralazine may T the bioavailability of beta-blockers with a high first-pass metabolism (e.g. propanolol and metoprolol), possibly due to alterations in hepatic blood flow or inhibited hepatic metabolism Monitor BP closely... [Pg.47]

VASODILATOR ANTIHYPERTENSIVES LIPID-LOWERING DRUGS Bosentan lowers simvastatin levels Uncertain bosentan moderately inhibits CYP3A4 Monitor lipid profile closely look for poor response to simvastatin... [Pg.50]

VASODILATOR ANTIHYPERTENSIVES-BOSENTAN SILDENAFIL 1 sildenafil levels Probable induction of metabolism Watch for poor response... [Pg.51]

VASODILATOR ANTIHYPERTENSIVES -BOSENTAN PROGESTOGENS 1 progesterone levels, which may lead to failure of contraception or poor response to treatment of menorrhagia Possibly induction of metabolism of progestagens Advise patients to use additional contraception for the period of intake and for 1 month after stopping co-administration with these drugs... [Pg.52]

VASODILATOR ANTIHYPERTENSIVES SYMPATHOMIMETICS-DIRECT Cases of t tachycardia when epinephrine is given for perioperative i BP in patients on hydralazine Additive effect Avoid co-administration... [Pg.53]

INSULIN VASODILATOR ANTIHYPERTENSIVES-DIAZOXIDE May t insulin requirement Diazoxide causes hyperglycaemia by inhibiting insulin release and probably by a catecholamine-induced extrahepatic effect. Used in the treatment of hypoglycaemia due to insulinomas Larger doses of insulin are often required, and there is a need to monitor blood sugar until adequate control of blood sugar is achieved... [Pg.409]

RIFAMPICIN VASODILATOR ANTIHYPERTENSIVES L bosentan levels Induction of metabolism Avoid co-administration... [Pg.538]

AZOLES - ITRACONAZOLE ANTI HYPERTENSIVES AND HEART FAILURE DRUGS -VASODILATOR ANTIHYPERTENSIVES - bosentan Azole antifungals t bosentan levels Azoles inhibit CYP3A4 and CYP2C9 Monitor LFTs closely... [Pg.570]

Dihydropyridines, are very attractive targets because of their wide range of pharmacological activities they have been reported for their vasodilating, antihypertensive, bronchodilating, anti-atherosclerotic, antioxidant, hepatoprotective,... [Pg.171]

Chromens and their derivatives are an important class of compounds possessing antiestrogenic, [165] potassium channel agonist, hypotensive [166], vasodilator, antihypertensive, p-adrenolytic [167] and antimicrobial activity [168]. Moreover, some derivatives show high antagonistic affinity for the retinoic acid receptor [169]. [Pg.211]

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