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Glucuronosyl transferase

Figure 32-14. Conjugation of bilirubin with glucuronic acid. The glucuronate donor, UDP-glucuronic acid, is formed from UDP-glucose as depicted. The UDP-glucuronosyl-transferase is also called bilirubin-UGT. Figure 32-14. Conjugation of bilirubin with glucuronic acid. The glucuronate donor, UDP-glucuronic acid, is formed from UDP-glucose as depicted. The UDP-glucuronosyl-transferase is also called bilirubin-UGT.
Polyphenols and flavanoids in rat liver microsomal fractions have been demonstrated to inhibit glucuronidation of estrone and estradiol in vitro (Zhu et al, 1998). In addition, flavonoids have also been found to induce phase I and II enzymes in rats including UDP-glucuronosyl transferase (Seiss et al, 1996). However, the effects of phytoestrogens have not been evaluated for either their inhibition or induction of glucuronosyl transferase activity. [Pg.68]

Hansen, K.T. and Stentoft, K. (1995) Characterization of benzazepine UDP-glucuronosyl-transferases in laboratory animals and man. Xenobiotica The Fate of Foreign Compounds in Biological Systems, 25,611-622. [Pg.224]

Capiello, M., Guiliani, L., Pacifici, G. M., Distribution of UDP-glucuronosyl transferase and its endogenous substrate uridine 5-diphosphoglucuronic acid in human tissues, Pur. J. Clin. Pharmacol. 1991, 41, 345-350. [Pg.325]

Bosma PJ, Chowdhury JR, Barker C et al. The genetic basis of the reduced expression of bilimbin UDP-glucuronosyl-transferase 1 in Gilbert s syndrome. [Pg.306]

Zhou, J., Zhang, J. and Xie, W. (2005) Xenobiotic nuclear receptor-mediated regulation of UDP-glucuronosyl-transferases. Current Drug Metabolism, 6, 289-298. [Pg.316]

Unconjugated bilirubin is taken into the hepatocytes by binding to membrane transport proteins and transported through the liver cells to the SER by proteins called ligandins. The SER is the location of a specific bilirubin-UDP-glucuronosyl transferase... [Pg.205]

Collier AC, Tingle MD, Keelan JA, Paxton JW, Mitchell MD (2000) A highly sensitive fluorescent microplate method for the determination of UDP-glucuronosyl transferase activity in tissues and placental cell lines. Drug Metab Dispos 28(10) 1184-1186... [Pg.281]

Beutler, E., Gelbart, T., and Demina, A. (1998) Racial variability in the UDP-glucuronosyl-transferase 1 (UGTIAI) promoter a balanced polymorphism for regulation of bilirubin metabolism Proc. Natl. Acad. Sci. U. S. A. 95, 8170-8174. [Pg.73]

Hyperbilirubinemia Most patients taking atazanavir experience asymptomatic elevations in indirect (unconjugated) bilirubin related to inhibition of UDP-glucuronosyl transferase (UGT). This hyperbilirubinemia is reversible upon discontinuation of atazanavir. [Pg.1829]

Conjugation of a drug with glucuronic acid via the glucuronosyl transferases will result in all of the following EXCEPT... [Pg.46]

Aono S, Yamada Y, Keino Het al. Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler-Najjar syndrome type II. Biochem Biophys Res Commun 1993 197 1239-1244. [Pg.285]

The other primary Phase II metabolic pathway is glucuronidation, which involves the formation ofglucuronic acid conjugates of xenobiotics. This is catalyzed by a family of UDP-glucuronosyl transferases (UGTs) in the presence of uridine diphosphate... [Pg.49]

See other pages where Glucuronosyl transferase is mentioned: [Pg.65]    [Pg.48]    [Pg.54]    [Pg.111]    [Pg.167]    [Pg.167]    [Pg.179]    [Pg.2]    [Pg.130]    [Pg.132]    [Pg.132]    [Pg.653]    [Pg.277]    [Pg.290]    [Pg.202]    [Pg.236]    [Pg.247]    [Pg.259]    [Pg.274]    [Pg.100]    [Pg.251]    [Pg.73]    [Pg.281]    [Pg.37]    [Pg.37]    [Pg.51]    [Pg.385]    [Pg.285]    [Pg.246]    [Pg.85]    [Pg.184]    [Pg.220]   
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See also in sourсe #XX -- [ Pg.25 ]

See also in sourсe #XX -- [ Pg.95 , Pg.155 , Pg.164 ]



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Human UDP-glucuronosyl transferases,

UDP-glucuronosyl transferases

UDP-glucuronosyl transferases UGTs)

Uridine diphosphate-glucuronosyl transferases

Uridine glucuronosyl transferase

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