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Uridine diphosphate glucuronosyl transferase

Smith PA, Sorich MJ, McKinnon RA, Miners JO. In silico insights Chemical and structural characteristics associated with uridine diphosphate-glucuronosyl-transferase substrate selectivity. Clin Exp Pharmacol Physiol 2003 30 836-40. [Pg.288]

Seo BG, Kwon HC, Oh SY et al (2009) Comprehensive analysis of excision repair complementation group 1, glutathione S-transferase, thymidylate synthase and uridine diphosphate glucuronosyl transferase 1A1 polymorphisms predictive for treatment outcome in patients with advanced gastric cancer treated with FOLFOX or FOLFIBI. Oncol Rep 22 127-136... [Pg.321]

UGT lAl uridine diphosphate glucuronosyl transferase lAl TPMT thiopurine methyl transferase SN-38 an active metabolite of ironotecan SN-38G a glucuronide metabolite of SN-38. [Pg.72]

The biotransformation of paracetamol (acetaminophen) at therapeutic concentrations in man can be seen in Figure 1. The major route of metabolism is via conjugation of the phenolic -OH group. The hepatic sulphotransferases have a high affinity for paracetamol (acetaminophen) but are rapidly saturated (either due to cofactor depletion or limited sulphotransferase availability), as were the uridine diphosphate glucuronosyl transferases (UDPGTs) which... [Pg.255]

Abbreviations used in this chapter bp, base pairs FAD, flavine adenine dinucleotide GLO, L-gulono-y-lactone oxidase ODS rat, osteogenic disorder Shionogi rat UDPGT, uridine diphosphate glucuronosyl-transferase. [Pg.19]

Quercetin and other flavonols are subject to metabolic conversion during the absorption process in the small intestine. Phase II enzymes including uridine 5 -diphosphate glucuronosyl transferase (UGT), phenol-sulfotransferase (PST),... [Pg.188]

The other primary Phase II metabolic pathway is glucuronidation, which involves the formation ofglucuronic acid conjugates of xenobiotics. This is catalyzed by a family of UDP-glucuronosyl transferases (UGTs) in the presence of uridine diphosphate... [Pg.49]

Polycyclic aromatic amines are readily absorbed into the body via the gastrointestinal tract, where metabolic activation takes place. Aryl amines are N-hydroxylated and subsequently glucuronidated via uridine diphosphate (UDP)-glucuronosyl transferase or sulfated by sulfotransferases, N-acetylation of the amine, and 0-acetylation of the N-hydroxy amine can occur. [Pg.2096]

See other pages where Uridine diphosphate glucuronosyl transferase is mentioned: [Pg.120]    [Pg.42]    [Pg.298]    [Pg.47]    [Pg.218]    [Pg.1067]    [Pg.4309]    [Pg.120]    [Pg.42]    [Pg.298]    [Pg.47]    [Pg.218]    [Pg.1067]    [Pg.4309]    [Pg.190]    [Pg.132]    [Pg.653]    [Pg.290]    [Pg.251]    [Pg.85]    [Pg.407]    [Pg.221]    [Pg.445]    [Pg.806]   
See also in sourсe #XX -- [ Pg.286 , Pg.286 ]



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Uridine glucuronosyl transferase

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